{"id":4839,"date":"2015-06-27T15:40:00","date_gmt":"2015-06-27T19:40:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/directory\/cook\/"},"modified":"2026-03-27T11:49:10","modified_gmt":"2026-03-27T15:49:10","slug":"cook","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/biochem\/directory\/cook\/","title":{"rendered":"Jean Cook"},"content":{"rendered":"<p style=\"text-align: center\"><span class=\"blue\"><em><strong>Chair &amp; Professor of Biochemistry and Biophysics<\/strong><\/em><\/span><span class=\"blue\"><em><strong><br \/>\nPharmacology &#8211; a joint appointment<br \/>\n<\/strong><\/em><\/span><em><strong>Community and Engagement Committee Member, Community Outreach<\/strong><\/em><\/p>\n<p style=\"text-align: center\"><span class=\"discreet\">(PhD &#8211; University of California, Berkeley)<\/span><\/p>\n<p class=\" \" style=\"text-align: center\"><strong><span style=\"background-color: #4682b4;color: #ffffff\">Accepting Rotation Students<\/span><\/strong><\/p>\n<div>\n<h3><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-thumbnail wp-image-10603\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-150x150.png\" alt=\"Trained Faculty Mentor endorsed by Office of Graduate Ed UNC Chapel Hill\" width=\"150\" height=\"150\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-150x150.png 150w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-64x64.png 64w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28114 size-thumbnail\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/07\/Mental-Health-logo-150x150.png\" alt=\"Mental Health\" width=\"150\" height=\"150\" \/><\/p>\n<h3><\/h3>\n<h3><span class=\"blue\">HONORS &amp; AWARDS<\/span><\/h3>\n<ul>\n<li><span data-olk-copy-source=\"MessageBody\">American Association for the Advancement of Science (AAAS), 2025<\/span><\/li>\n<li>W. M. Keck Foundation Award, 2015<\/li>\n<li>Academy of Educators Elected Fellow, 2012<\/li>\n<li>The Jefferson-Pilot Fellowship in Academic Medicine, 2010-2014<\/li>\n<li>Academy of Educators Teaching Excellence Award, 2010<\/li>\n<li>National Cancer Institute&#8217;s Howard Temin Award, 2003-2008<\/li>\n<\/ul>\n<h3><span class=\"blue\">RESEARCH<\/span><\/h3>\n<div><strong><span style=\"color: #666666\"><i>Cell Cycle Control in Human Cells<\/i><\/span><\/strong><\/div>\n<div><span style=\"color: #666666\"><i>\u00a0<\/i><\/span><\/div>\n<div align=\"justify\"><span style=\"color: #666666\">Our lab studies the regulation of the mammalian cell cycle with a <\/span><span style=\"line-height: 1.43em\">particular focus on the cell <\/span><span style=\"line-height: 1.43em\">cycle phase transitions <\/span><span style=\"line-height: 1.43em\">r<\/span><span style=\"line-height: 1.43em\">elated to DNA replication and <\/span><span style=\"line-height: 1.43em\">to cell cycle exit. <\/span><\/div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9500\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2015\/06\/Cook-cell-image-for-website-300x287.jpg\" alt=\"photo of 4 cells Jean Cook research image for website\" width=\"300\" height=\"287\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2015\/06\/Cook-cell-image-for-website-300x287.jpg 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2015\/06\/Cook-cell-image-for-website-768x735.jpg 768w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2015\/06\/Cook-cell-image-for-website-1024x980.jpg 1024w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2015\/06\/Cook-cell-image-for-website.jpg 1129w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<div>\n<p><span style=\"line-height: 1.43em\">Cells coordinate progression through the cell division cycle with a wide variety of extracellular and intracellular information by regulating the activity and abundance of key cell cycle proteins.<\/span><\/p>\n<div align=\"justify\">\n<p><span style=\"color: #666666\"> Many proteins have more than one function in the cell cycle, and one of our goals is to understand how those different functions are integrated to preserve normal cell proliferation.<\/span><\/p>\n<\/div>\n<div>\n<div align=\"justify\"><span style=\"color: #666666\">We manipulate cell cycle proteins in human cell lines using a variety of molecular genetic tools. We deplete proteins from cells using siRNA techniques, overproduce proteins using recombinant plasmid or viral vectors, and inhibit activities with pharmacological reagents. New projects employ live cell imaging and single cell analysis of protein abundance during the cell cycle. Ultimately we hope to achieve a greater understanding of normal cell cycle control so that future therapeutic tools related to regeneration and cancer treatment can be developed.<\/span><\/div>\n<div><span style=\"color: #666666\">\u00a0<\/span><\/div>\n<div><span style=\"color: #666666\">For more detailed information, as well as an introduction to the members of the Cook lab, visit our webpage:<\/span><\/div>\n<div><a class=\"external-link\" style=\"line-height: 1.43em\" title=\"\" href=\"https:\/\/sites.google.com\/site\/cooklabgroup\/home\" target=\"_self\" rel=\"noopener noreferrer\">https:\/\/sites.google.com\/site\/cooklabgroup\/home<\/a><\/div>\n<h3><span class=\"blue\">CORE TECHNIQUES<\/span><\/h3>\n<ul>\n<li>cell proliferation dynamics<\/li>\n<li>genome stability control<\/li>\n<li>molecular biology<\/li>\n<li>quantitative single cell analysis<\/li>\n<\/ul>\n<h3><span class=\"blue\">PUBLICATIONS<\/span><\/h3>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/collections\/58733275\/?sort=pubdate\">Click for a complete list of publications<\/a><\/p>\n<div>\n<hr \/>\n<\/div>\n<h3><span class=\"blue\">Lab Contact:<\/span><\/h3>\n<div>Lab Rooms: 3070G-H Genetic Medicine<\/div>\n<div>Lab Phone: 919-966-3935<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>Research: Cell Cycle Control<\/p>\n","protected":false},"featured_media":32730,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-4839","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Jean Cook | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, 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