{"id":4845,"date":"2015-06-22T12:35:00","date_gmt":"2015-06-22T16:35:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/directory\/dohlman\/"},"modified":"2025-10-27T13:27:17","modified_gmt":"2025-10-27T17:27:17","slug":"dohlman","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/biochem\/directory\/dohlman\/","title":{"rendered":"Henrik Dohlman"},"content":{"rendered":"<p><!-- title_affiliation --><\/p>\n<p style=\"text-align: center\"><strong><span class=\"blue\"><em>Sanford Steelman Distinguished Professor and Chair, Department of Pharmacology<\/em><\/span><\/strong><br \/>\nBiochemistry &amp; Biophysics &#8211; joint appointment<br \/>\n<span class=\"directory-title clearfix\">Member, <\/span><span class=\"directory-title clearfix\">Lineberger Comprehensive Cancer Center<\/span><br \/>\n<span class=\"discreet\">(PhD &#8211; Duke University)<\/span><\/p>\n<div>\n<div class=\"directory-post-excerpt\"><\/div>\n<div class=\"directory-profile single \">\n<div class=\"directory-post-content\">\n<h2><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-11601\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png\" alt=\"\" width=\"300\" height=\"204\" \/><\/h2>\n<h2>Research Interests<\/h2>\n<ul>\n<li>Regulators of G protein Signaling<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<h3 class=\"p1\">Mechanisms of Cell Desensitization: Regulators of G protein Signaling.<\/h3>\n<p class=\"p2\">Research in the\u00a0<a href=\"https:\/\/www.med.unc.edu\/pharm\/dohlmanlab\/research\">Dohlman Lab<\/a>\u00a0is centered on\u00a0G proteins\u00a0and\u00a0G protein-coupled receptors\u00a0(GPCRs). GPCRs are the target of many pharmaceuticals, hormones and neurotransmitters, as well as most environmental signals. Generally speaking, persistent stimulation of G proteins lead to desensitization. Familiar examples\u00a0include desensitization to light, odors and chemical stimulants such as caffeine.<\/p>\n<p class=\"p2\">Receptors, G proteins, and effector MAP kinases are conserved in evolution and are even found in the simplest eukaryotes such as yeast.\u00a0Through large-scale genomics, proteomics and metabolomics analysis the lab has identified new mutants with altered signaling and desensitization properties. These are then characterized biochemically and biophysically using homologous proteins in humans. This approach led to the identification\u00a0in yeast of a family of desensitization factors called\u00a0RGS proteins\u00a0(Regulator of G protein signaling). Whereas GPCRs activate G proteins,\u00a0RGS proteins inactivate G proteins, by\u00a0accelerating their GTPase activity.<\/p>\n<p class=\"p2\">Thus, RGS proteins serve as the molecular \u2018brakes\u2019 in cell signaling: they diminish our sensitivity to enviromental signals, neurotransmitters and\u00a0pharmaceuticals over time.<\/p>\n<p class=\"p2\">Building on the RGS work, the lab is currently investigating how nutritional and stress signals, and their consequent molecular processes (e.g. feedback phosphorylation, protein ubiquitination,\u00a0intracellular pH changes) can limit activation of competing signaling pathways. Efforts in collaboration with\u00a0Tim Elston\u2019s group seek to\u00a0construct computational models of constituent signaling networks and pathways. The long-term objective is to devise predictive models of signal\u00a0transduction in more complex systems, and ultimately determine how specific stimuli or drugs will influence the signaling network, in addition to\u00a0specific target enzymes or receptors.<\/p>\n<h2>Publications<\/h2>\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/henrik.dohlman.1\/bibliography\/public\/\">View complete list of publications in NCBI bibliography<\/a><\/strong><\/p>\n<\/div>\n<\/div>\n<h3><\/h3>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>Research: Regulators of G protein signaling<\/p>\n","protected":false},"featured_media":4846,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-4845","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the 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Henrik"],"_upd_last_name":["Dohlman"],"_upd_first_name":["Henrik"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<em><strong><span class=\"blue\">Professor &amp; Chair of Pharmacology\r\n<\/span><\/strong><\/em>Research: Regulators of G protein signaling\r\n\r\n<strong>TRAINED MENTOR<\/strong>\r\n\r\n<span style=\"color: #333333\">CB# 7365, 4016 Genetic Medicine\r\n<\/span><span style=\"color: #333333\">tel: 919-843-6894<\/span> I <a class=\"email-link\" title=\"\" href=\"mailto:hdohlman@med.unc.edu\" target=\"_self\">Email<\/a>\r\n<a href=\"https:\/\/www.med.unc.edu\/pharm\/dohlmanlab\/\">Dohlman lab website<\/a>"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"hdohlman@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-843-6894","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"120 Mason Farm Road, CB# 7365","address-2":"4016 Genetic Medicine","campus-box":"","city":"Chapel 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