{"id":4857,"date":"2017-01-25T20:50:00","date_gmt":"2017-01-26T01:50:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/directory\/liu\/"},"modified":"2025-08-19T13:52:22","modified_gmt":"2025-08-19T17:52:22","slug":"liu","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/biochem\/directory\/liu\/","title":{"rendered":"Pengda Liu"},"content":{"rendered":"<p><!-- title_affiliation --><\/p>\n<p style=\"text-align: center\"><span class=\"blue\"><em><strong>Associate Professor of Bioc<\/strong><\/em><\/span><strong style=\"line-height: 1.43em\"><span class=\"blue\"><em>hemistry and Biophysics<\/em><\/span><br \/>\n<\/strong><span class=\"discreet\">(PhD &#8211; East Carolina University)<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-thumbnail wp-image-10603\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-150x150.png\" alt=\"Trained Faculty Mentor endorsed by Office of Graduate Ed UNC Chapel Hill\" width=\"150\" height=\"150\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-150x150.png 150w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-64x64.png 64w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/p>\n<div>\n<h3><span class=\"blue\">HONORS &amp; AWARDS<\/span><\/h3>\n<ul>\n<li>Yang Family Biomedical Scholars Award, UNC School of Medicine, 2023-24<\/li>\n<li>Phillip and Ruth Hettleman Prizes for Scholarly Achievement, UNC-Chapel Hill, 2023<\/li>\n<li>Andrew McDonough B+ Foundation Award, 2022<\/li>\n<li>American Type Culture Collection (ATCC) Innovation Challenge Winner, 2021<\/li>\n<li>Department of Defense Kidney Cancer Research Program Idea Development Award, 2021<\/li>\n<li>Sapphire North America\u2019s Return to Research Grant, 2021<\/li>\n<li>Jefferson-Pilot Fellowship in Academic Medicine, 2021<\/li>\n<li>Breast Cancer Alliance Young Investigator Grant, 2020<\/li>\n<li>Gabrielle\u2019s Angel Foundation Medical Research Award, 2020<\/li>\n<li>Avantor Sciences Foundation Grant, 2019<\/li>\n<li>UNC Lineberger Developmental Grant, 2019<\/li>\n<li>Department of Defense Peer Reviewed Cancer Career Development Award (declined), 2019<\/li>\n<li>North Carolina Biotechnology Center Flash Grant, 2019<\/li>\n<li>Joseph Li Travel Award, 2019<\/li>\n<li>NCTraCS Pilot Grant, 2019<\/li>\n<li>V Scholar Award, V Foundation for Cancer Research, 2018<\/li>\n<li>UNC IBM Junior Faculty Development Award, 2017<\/li>\n<li>Atomwise Artificial Intelligence Molecular Screen (AIMS) Award, 2017<\/li>\n<li>East Carolina University 40 under 40 Leadership Award, 2016<\/li>\n<li>National Cancer Institute Pathway to Independence (K99) Award, 2014<\/li>\n<li>NIH\/NHLBI Ruth L. Kirschstein National Research Service Award, 2012<\/li>\n<li>Carol F. Volkman Award, Brody School of Medicine, East Carolina University, 2006<\/li>\n<\/ul>\n<h3 class=\"blue\"><span class=\"blue\">RESEARCH SUMMARY<\/span><strong><span class=\"blue\"><br \/>\n<\/span> <\/strong><\/h3>\n<div class=\"alert alert-gray\" style=\"text-align: justify\">\n<p>The Pengda Liu Lab is interested in deciphering the molecular mechanisms underlying aberrant signaling events that contribute to tumorigenesis mediated by protein modifications and protein-protein interactions. Understanding these events may lead to identification of novel drug targets and provide new treatment strategies to combat human cancer. To this end, we are interested in the potential of enzymes, and their inhibition, for generating traditional inhibitory chemical compounds or antibodies as potential therapeutic tools.<\/p>\n<p>Cell signaling networks determine cell fate and aberrant activation of oncogenic signaling is a key mechanism during cancer development; however, cell-signaling networks are complicated and dynamic with fluxes in both space and time. Thus, to understand how cancer-associated aberrant cell decisions are made requires addressing the following questions through a global view of cell signaling networks, including to identify the key molecular events that lead to malignant diseases but do not occur in healthy cells and to elucidate how can cancer-associated signaling modules be targeted for cancer treatment.<\/p>\n<\/div>\n<h3><span class=\"blue\">PUBLICATIONS<\/span><\/h3>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=liu+pengda%5BAuthor%5D\">complete list of publications for Pengda Liu<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>Cell signaling; cancer; mTOR; Akt; post-translational modification; protein-protein interaction<\/p>\n","protected":false},"featured_media":20162,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-4857","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pengda Liu | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/directory\/liu\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pengda Liu | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Cell signaling; 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cancer; mTOR; Akt; post-translational modification; protein-protein interaction\r\n\r\n<strong>TRAINED MENTOR<\/strong>\r\n\r\nCB# 7295, 21-246 Lineberger\r\n919-966-3522 | <a href=\"mailto:pengda_liu@med.unc.edu\">Email<\/a>\r\n\r\n<a href=\"https:\/\/unclineberger.org\/pengdaliulab\/\">Lui Lab Website<\/a>"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"pengda_liu@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-966-3522","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"21-246 Lineberger Cancer Center","address-2":"450 West Drive, P. Liu lab","campus-box":"Campus Box 7295","city":"Chapel Hill","state":"NC","zip":"27599-7295"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/directory\/4857","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/directory\/4857\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media\/20162"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media?parent=4857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}