{"id":4872,"date":"2015-06-27T15:40:00","date_gmt":"2015-06-27T19:40:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/directory\/strahl-2\/"},"modified":"2025-08-19T14:00:52","modified_gmt":"2025-08-19T18:00:52","slug":"strahl-2","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/biochem\/directory\/strahl-2\/","title":{"rendered":"Brian D. Strahl"},"content":{"rendered":"<p class=\" \" style=\"text-align: center\"><span class=\"blue\"><em><strong><span class=\"TextRun SCXW137204465 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW137204465 BCX8\">Associate Chair for Operations and Strategy<\/span><\/span><br \/>\nOliver Smithies investigator, Professor<br \/>\n<\/strong><\/em><\/span><span class=\"blue\"><em><strong><span data-olk-copy-source=\"MessageBody\">Associate Dean for Basic Research &#8211; School of Medicine<\/span><br \/>\n<\/strong><\/em><\/span><em><strong>Community and Engagement Committee Member &#8211; Professional Success<\/strong><\/em><\/p>\n<p class=\" \" style=\"text-align: center\">Faculty Director, <a href=\"https:\/\/www.med.unc.edu\/csb\/unc-peptides\/\">UNC High-throughput Peptide Synthesis and Array Facility<\/a><br \/>\nCo-Director of <a class=\"brand\" href=\"https:\/\/www.med.unc.edu\/epigenetics\">Chromatin and Epigenetics Program<\/a><br \/>\n<span class=\"discreet\">(PhD &#8211; NC State University)<\/span><\/p>\n<div>\n<h3><strong><span class=\"blue\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-10603\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-300x181.png\" alt=\"Trained Faculty Mentor endorsed by Office of Graduate Ed UNC Chapel Hill\" width=\"300\" height=\"181\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-300x181.png 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-768x464.png 768w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-1024x619.png 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/span><\/strong><\/h3>\n<h3><span class=\"blue\">HONORS &amp; AWARDS<\/span><\/h3>\n<ul>\n<li>UNC Excellence in Basic Science Mentoring Award, 2019<\/li>\n<li>UNC Oliver Smithies Investigator, 2018<\/li>\n<li>NIH Maximizing Investigators&#8217; Research Award (MIRA), National Institute of General Medical Sciences, 2018<\/li>\n<li>Philip &amp; Ruth Hettleman Prize, 2009<\/li>\n<li>NIH Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) award, 2008<\/li>\n<li>Jefferson-Pilot Fellow in Academic Medicine, UNC, 2006<\/li>\n<li>North Carolina State University Outstanding Alumnus Award, 2005<\/li>\n<li>Schering-Plough Research Institute Award, 2004<\/li>\n<li>Presidential Early Career Award for Scientists and Engineers (PECASE), 2003<\/li>\n<li>Pew Scholar (Pew Scholars Program in the Biomedical Sciences), 2003<\/li>\n<\/ul>\n<h3><span style=\"color: inherit;text-align: justify\">RESEARCH<\/span><\/h3>\n<div class=\"alert alert-gray\" style=\"text-align: justify\">Eukaryotic genomes are packaged into the nuclei of cells through the actions of histone proteins. These proteins not only play a role in condensing the genome but are fundamental to establishing and maintaining chromatin domains such as euchromatin and heterochromatin. Our lab is addressing how chromatin organization achieved and what factors make the underlying DNA permissive to the protein machineries that drive transcription, replication, recombination, and repair. A large body of work shows that histone post-translational modifications are central to the regulation of chromatin structure and function. These modifications, which include acetylation and methylation, decorate histones and function, at least in part, by recruiting chromatin regulatory proteins to the sites of these modifications. Current efforts are aimed at understanding how histone modifications are installed and removed, and how they are interpreted to regulate genome function.<\/div>\n<h3><span class=\"blue\">SELECTED PUBLICATIONS<\/span><\/h3>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Strahl+Brian+D&amp;sort=date\">Link to all pubs<\/a><\/p>\n<hr \/>\n<h3><span class=\"blue\">Lab Contact<\/span><\/h3>\n<p>3060 Genetic Medicine<\/p>\n<p>CB #7260<\/p>\n<p>Chapel Hill, NC 27599<\/p>\n<p>Office Phone: 919.843.3896 Lab Phone: 919.843.3935<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>Research: Histone modifications and epigenetics; core techniques: yeast genetics, peptide synthesis, peptide arrays, mammalian cell culture<\/p>\n","protected":false},"featured_media":31204,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-4872","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Brian D. 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Strahl"],"_upd_reverse_display_name":["Strahl, Brian"],"_upd_last_name":["Strahl"],"_upd_first_name":["Brian"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<em><strong><span class=\"TextRun SCXW137204465 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW137204465 BCX8\">Associate Chair for Operations and Strategy<\/span><\/span>, <span data-olk-copy-source=\"MessageBody\">Oliver Smithies Investigator, <\/span>Professor\r\n<\/strong><strong><span class=\"blue\"><span data-olk-copy-source=\"MessageBody\">Associate Dean for Basic Research,\u00a0<\/span><\/span>\r\nCommunity and Engagement Committee Member, Professional Success<\/strong><\/em>\r\n\r\nResearch: Histone modifications and epigenetics; core techniques: yeast genetics, peptide synthesis, peptide arrays, mammalian cell culture\r\n\r\n<strong>TRAINED MENTOR<\/strong>\r\n\r\nCB# 7260, 3060 Genetic Medicine\r\n919-843-3896 | <a href=\"mailto:brian_strahl@med.unc.edu\">Email<\/a>\r\n\r\n<a href=\"https:\/\/strahl-lab.org\/\">Strahl Lab Website<\/a>"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"brian_strahl@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-843-3896","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"120 Mason Farm Road, CB# 7260","address-2":"3060 Genetic Medicine","campus-box":"","city":"Chapel Hill","state":"NC","zip":"27599-7260"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/directory\/4872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/directory\/4872\/revisions"}],"predecessor-version":[{"id":31963,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/directory\/4872\/revisions\/31963"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media\/31204"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media?parent=4872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}