{"id":12051,"date":"2019-03-06T13:15:01","date_gmt":"2019-03-06T18:15:01","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=12051"},"modified":"2019-12-02T13:41:27","modified_gmt":"2019-12-02T18:41:27","slug":"cohen-schisler-awarded-3-1-million-alzheimers-grant","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/cohen-schisler-awarded-3-1-million-alzheimers-grant\/","title":{"rendered":"Cohen, Schisler awarded $3.1 million Alzheimer\u2019s grant"},"content":{"rendered":"<figure id=\"attachment_12052\" class=\"thumbnail wp-caption alignright\" style=\"width: 310px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-12052\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/12\/cohen-pict-2019-300x201.jpg\" alt=\"Todd Cohen PhD and Jonathan Schisler PhD\" width=\"300\" height=\"201\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/12\/cohen-pict-2019-300x201.jpg 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/12\/cohen-pict-2019-768x512.jpg 768w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/12\/cohen-pict-2019-600x403.jpg 600w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/12\/cohen-pict-2019.jpg 954w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"caption wp-caption-text\">Todd Cohen, PhD, and Jonathan Schisler, PhD<\/figcaption><\/figure>\n<p>Todd Cohen, PhD, assistant professor of neurology with an adjunct appointment in biochemistry and biophysics, and Jonathan Schisler, PhD, assistant professor of pharmacology, were awarded a $3.1-million grant from the National Institute on Aging titled, \u201cDual CHIP Functions Control Tau Triage in Alzheimer\u2019s Disease.\u201d<\/p>\n<p>The five-year project will combine the complimenting expertise of Cohen and Schisler, allowing them to study like never before key concepts related to the regulation of tau, a protein that accumulates and aggregates in patients with Alzheimer\u2019s disease. \u00a0The overarching goal of the study is to provide a new framework to better understand and target pathological tau species to alleviate tau-mediated toxicity and neurodegeneration in patients with Alzheimer\u2019s disease.<\/p>\n<p>Cohen, a member of the UNC Neuroscience Center, is an expert in tau biology, focusing on how specific modifications to the tau protein contribute to the progression of Alzheimer\u2019s disease and cognitive dysfunction. Schisler, who holds a joint appointment in the department of pathology and lab medicine and is a member of the McAllister Heart Institute, is an expert in the C-terminal Hsc-70 interacting protein (CHIP), an enzyme that functions as a key regulator of protein quality control, particularly in age-related diseases.<\/p>\n<p>The study will define the critical events that occur during early-stage tau triage, a time period in healthy adults during which aberrant tau aggregation is counteracted by a neuroprotective response that involves the activity of CHIP.<\/p>\n<p>By better understanding the intricacies of this biological process, the researchers hope to gain insights to inform the development of future therapeutic options for patients.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Todd Cohen, PhD, and Jonathan Schisler, PhD, will investigate the new ideas related to the regulation of the Tau protein, which plays a role in Alzheimer\u2019s disease.<\/p>\n","protected":false},"author":41619,"featured_media":12052,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[230,10,233],"class_list":["post-12051","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-2019-faculty-year-review","tag-news_faculty","tag-news_faculty_s19","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cohen, Schisler awarded $3.1 million Alzheimer\u2019s grant | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/cohen-schisler-awarded-3-1-million-alzheimers-grant\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cohen, Schisler awarded $3.1 million Alzheimer\u2019s grant | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Todd Cohen, PhD, and Jonathan Schisler, PhD, will investigate the new ideas related to the regulation of the Tau protein, which plays a role in Alzheimer\u2019s disease.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/cohen-schisler-awarded-3-1-million-alzheimers-grant\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-03-06T18:15:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-12-02T18:41:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/12\/cohen-pict-2019.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"954\" \/>\n\t<meta property=\"og:image:height\" content=\"640\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/cohen-schisler-awarded-3-1-million-alzheimers-grant\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/cohen-schisler-awarded-3-1-million-alzheimers-grant\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"Cohen, Schisler awarded $3.1 million Alzheimer\u2019s grant\",\"datePublished\":\"2019-03-06T18:15:01+00:00\",\"dateModified\":\"2019-12-02T18:41:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/cohen-schisler-awarded-3-1-million-alzheimers-grant\/\"},\"wordCount\":281,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/cohen-schisler-awarded-3-1-million-alzheimers-grant\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/12\/cohen-pict-2019.jpg\",\"keywords\":[\"2019-faculty-year-review\",\"Faculty &amp; 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