{"id":12391,"date":"2019-12-12T09:59:36","date_gmt":"2019-12-12T14:59:36","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=12391"},"modified":"2019-12-12T10:01:21","modified_gmt":"2019-12-12T15:01:21","slug":"scientists-visualize-competition-between-healthy-dysfunctional-platelets","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/scientists-visualize-competition-between-healthy-dysfunctional-platelets\/","title":{"rendered":"Scientists Visualize Competition Between Healthy, Dysfunctional Platelets"},"content":{"rendered":"
\"Wolfgang
Wolfgang Bergmeier, PhD<\/figcaption><\/figure>\n

Bleeding can happen during surgery, after trauma, or even spontaneously. And when it does, blood cells called platelets rush in to stick to the injured blood vessels and stop bleeding as quickly as possible. Or at least that\u2019s what should happen. When the cause of bleeding is not having enough platelets, that\u2019s called thrombocytopenia. Other causes of bleeding involve platelets that don\u2019t work well, and these conditions are called platelet function disorders.<\/p>\n

No matter the cause of bleeding, one of the most common treatments is platelet transfusion therapy, which doctors have found works quite well for people with thrombocytopenia because they simply need more platelets. But in people with certain platelet function disorders, platelet transfusions are not effective.<\/p>\n

Previous studies have suggested that the patient\u2019s dysfunctional platelets might get in the way of the healthy transfused platelets. The lab of Wolfgang Bergmeier, PhD, professor of biochemistry and biophysics, hypothesized that there is competition between the dysfunctional platelets and the healthy transfused platelets at the site of blood vessel injury, and this would cause platelet transfusion therapy to be less effective.<\/p>\n

\"Bobby
Robert H. Lee, PhD<\/figcaption><\/figure>\n

Robert H. Lee, PhD, a postdoctoral fellow in the Bergmeier lab, led experiments using mouse models and state-of-the-art imaging to visualize how healthy and dysfunctional platelets interact at the site of injury.<\/p>\n

\u201cWe found that while thrombocytopenic mice only needed a small number of transfused platelets to prevent bleeding, a mouse model of a platelet function disorder needed many more transfused platelets,\u201d Lee said. \u201cIn fact, bleeding would only stop if the ratio of dysfunctional to healthy platelets was 2:1 or less.\u201d<\/p>\n

When Lee and colleagues performed real-time imaging studies, they observed that healthy and dysfunctional platelets do indeed compete with each other for space in the injured blood vessel. Their studies also characterized the molecular mechanisms by which dysfunctional platelets delay the adhesion and function of transfused cells, information that will be critical to improve treatment strategies.<\/p>\n

\u201cWe hope these findings can help guide future clinical studies and ultimately improve guidelines on the optimal use of platelet transfusions to prevent bleeding in patients with certain platelet function disorders,\u201d said Bergmeier, senior author and member of the recently established UNC Blood Research Center.<\/p>\n

These findings were published in <\/i>Science Translational Medicine. Lee is first author and Bergmeier is senior author. Other authors include <\/i>Raymond Piatt, Ankita Dhenge, Mar\u00eda Lozano, Ver\u00f3nica Palma-Barqueros, and Jos\u00e9 Rivera.<\/i><\/p>\n

The research was funded by the National Institutes of Health, the <\/i>Instituto de Salud Carlos III and Feder, and Fundaci\u00f3n S\u00e9neca.<\/i><\/p>\n

News courtesy of UNC Health Care. Media contact: Mark Derewicz.<\/a><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"

In some patients with blood disorders, platelet transfusion therapy doesn\u2019t work. UNC School of Medicine scientists used real-time imaging and mouse models to show why. 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