{"id":12740,"date":"2020-02-06T09:30:50","date_gmt":"2020-02-06T14:30:50","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=12740"},"modified":"2020-02-07T08:26:45","modified_gmt":"2020-02-07T13:26:45","slug":"characterization-of-the-plant-homeodomain-phd-reader-family-for-their-histone-tail-interactions","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/characterization-of-the-plant-homeodomain-phd-reader-family-for-their-histone-tail-interactions\/","title":{"rendered":"Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions"},"content":{"rendered":"

How the genetic code, in the form of DNA, is packaged into cells is not well understood. \u00a0Many studies have found that DNA packaging is mediated through the actions of histone proteins that spool the DNA into structures called nucleosomes. \u00a0While histones are responsible for DNA packaging, it turns out that chemical modifications or molecular tags on the histones provide the key instructions for how DNA becomes packed or opened up for functions like the expression of genes. \u00a0A mystery in understanding how the chemical histone tags function has been the identification of the proteins these tags recruit. \u00a0In this study, we set out to analyzed a large family of proteins that recognizes these histone modifications, plant homeodomains (PHDs). \u00a0We have studied 123 PHD proteins with respect to their binding interactions with chemical histone tags and thoroughly described binding preference for 31 histone H3 binding PHDs in the context of various modifications (i.e. methylation, acetylation, phosphorylation, etc.). \u00a0By using high-throughput arraying methods and sensitive proximity-based binding assays, this work provides a large database of information with respect to how PHDs interact with histones and their chemical tags.<\/span><\/p>\n

\"Kanishk
Kanishk Jain, PhD, postdoctoral fellow (Strahl lab)<\/figcaption><\/figure>\n

A study of the epigenetic effector proteins, Plant Homeodomains (PHDs), from Dr. Brian D. Strahl’s lab titled “Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions,” was published in Epigenetics & Chromatin on January 24th, 2020 (<\/span>https:\/\/doi.org\/10.1186\/s13072-020-0328-z<\/a>). The work was authored by Dr. Kanishk Jain, a postdoctoral trainee in Dr. Brian D. Strahl’s lab, and collaborators from Dr. Mark T. Bedford’s lab at MD Anderson and EpiCypher Inc.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Published in Epigenetics & Chromatin. The work was authored by Dr. Kanishk Jain, a postdoctoral trainee in Dr. Brian D. Strahl’s lab, and collaborators from Dr. Mark T. Bedford’s lab at MD Anderson and EpiCypher Inc. <\/p>\n","protected":false},"author":41619,"featured_media":12750,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[298,340,179,319,26],"class_list":["post-12740","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_2020","tag-news_studentpostdocstaff_s20","tag-news_postdoc-scholars","tag-strahl-news","tag-strahl_news","odd"],"acf":[],"yoast_head":"\nCharacterization of the plant homeodomain (PHD) reader family for their histone tail interactions | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/characterization-of-the-plant-homeodomain-phd-reader-family-for-their-histone-tail-interactions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Published in Epigenetics & Chromatin. The work was authored by Dr. Kanishk Jain, a postdoctoral trainee in Dr. Brian D. Strahl's lab, and collaborators from Dr. Mark T. 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