{"id":13594,"date":"2020-04-23T14:07:44","date_gmt":"2020-04-23T18:07:44","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=13594"},"modified":"2020-04-24T14:34:47","modified_gmt":"2020-04-24T18:34:47","slug":"grad-student-megan-justice-first-authored-paper-in-cell-reports","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/grad-student-megan-justice-first-authored-paper-in-cell-reports\/","title":{"rendered":"Grad student Megan Justice first authored paper in Cell Reports!"},"content":{"rendered":"

Publication “A WIZ\/Cohesin\/CTCF Complex Anchors DNA Loops to Define Gene Expression and Cell Identity” in Cell Reports<\/p>\n

\"DowenJustice et al. report a role for the protein WIZ (Widely Interspaced Zinc fingers) in spatially organizing the genome inside the nucleus and maintaining the identity of a cell. The genome is highly compacted in order to fit the roughly 2 meters of DNA inside of the nucleus of every cell. This organization of DNA is not random, in fact some specific long-range DNA contacts are important for the regulation of genes that define a cell type. The work described here is important because it identifies a new structural regulator of genome organization. Furthermore, it demonstrates that WIZ is required to maintain the identity of stem cells. Overall, this research sheds molecular insight on the proteins and processes that link three-dimensional genome structure and genome function. With knowledge of how DNA organization regulates the expression of genes, we may better understand how this process goes wrong in human disease.<\/span><\/p>\n

Check out our paper on WIZ and its role with Cohesin and CTCF in gene control and genome organization in embryonic stem cells. Congratulations Megan Justice, Zach <\/span>Carico and Holden <\/span>Stefan! — Jill Dowen, Ph.D. Read the publication in Cell Reports<\/a><\/span><\/p>\n

\"Megan
Megan Justice, first author graduate student in Dowen lab<\/figcaption><\/figure>\n
\"Zach
Zach Carico, postdoctoral fellow<\/figcaption><\/figure>\n
\"Jill
Jill Dowen, PhD, Assistant Professor<\/span><\/a><\/figcaption><\/figure>\n

Dowen lab research website<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Publication “A WIZ\/Cohesin\/CTCF Complex Anchors DNA Loops to Define Gene Expression and Cell Identity” in Cell Reports<\/p>\n","protected":false},"author":41619,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[298,13],"class_list":["post-13594","post","type-post","status-publish","format-standard","hentry","category-news","tag-news_2020","tag-news_students","odd"],"acf":[],"yoast_head":"\nGrad student Megan Justice first authored paper in Cell Reports! | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/grad-student-megan-justice-first-authored-paper-in-cell-reports\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Grad student Megan Justice first authored paper in Cell Reports! 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