{"id":13685,"date":"2020-04-02T19:33:41","date_gmt":"2020-04-02T23:33:41","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=13685"},"modified":"2020-05-01T13:52:59","modified_gmt":"2020-05-01T17:52:59","slug":"identifying-prevention-or-treatment-strategies-for-covid-19-could-copper-disable-the-virus-behind-covid-19","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/identifying-prevention-or-treatment-strategies-for-covid-19-could-copper-disable-the-virus-behind-covid-19\/","title":{"rendered":"Identifying prevention or treatment strategies for COVID-19: Could Copper Disable the Virus Behind COVID-19?"},"content":{"rendered":"
\"michael
BCBP Alumnus Michael Johnson, PhD, assistant professor of immunobiology<\/figcaption><\/figure>\n

Our Alumnus Michael Johnson<\/strong>, PhD, assistant professor of immunobiology, will work with Koenraad Van Doorslaer, PhD assistant professor in the\u00a0College of Agriculture and Life Sciences<\/a>,\u00a0at the University of Arizona – Health Sciences – College of Medicine to investigate the use of copper compounds in preventing infection.<\/p>\n

A team of UArizona Health Sciences researchers is studying whether or not certain copper-based chemical compounds could potentially stop the virus that causes COVID-19 dead in its tracks.<\/p>\n

On March 17,\u00a0a study<\/a>\u00a0about how long the virus that causes COVID-19 survives on various surfaces was published in the\u00a0New England Journal of Medicine<\/em>. Led by the National Institute of Allergy and Infectious Diseases, the study found that the virus, called SARS-CoV-2, can survive on plastic and stainless steel for up to three days, on cardboard for 24 hours, and on copper for just four hours.<\/p>\n

As soon as the study appeared online, Michael Johnson\u2019s computer started \u201cpinging\u201d with incoming emails from frenzied colleagues asking, \u201cHave you seen this?\u201d Johnson, an expert on copper\u2019s toxicity to pathogens, an assistant professor of immunobiology in the\u00a0College of Medicine\u00a0\u2013 Tucson<\/a>, and a member of the\u00a0BIO5 Institute<\/a>, hadn\u2019t seen it. Yet.<\/p>\n

Johnson\u2019s lab uses chemical compounds that deliver copper to disease-causing bacteria like\u00a0Streptococcus pneumoniae<\/em>\u00a0and MRSA. The copper kills them. Building on the new COVID-19 findings, Johnson is now studying whether or not these same compounds could block SARS-CoV-2 from even entering human cells or hinder their ability to replicate once they do.<\/p>\n

\u201cThere is precedence for this to work, but I think we can add a novel twist,\u201d explained Johnson.<\/p>\n

The compounds, he thinks, could work like this: SARS-CoV-2, like all coronaviruses, is studded with spike proteins\u2014necessary for entry into a host cell\u2014resembling the spikes on a crown. These proteins require metals like zinc to function, and they steal these metals from our own cells. If instead of stealing useful metals like zinc, Johnson could deliver toxic copper to the virus\u2019s spike proteins, it could be rendered inoperable. The process is called \u201cmismetallation,\u201d and Johnson compares it to replacing a car\u2019s steering wheel with bike handles and its ignition with the pull cord on a lawnmower.<\/p>\n

\u201cEventually, the car is going to become undriveable,\u201d he said.<\/p>\n

Just one problem. \u201cI\u2019m not a virologist\u2014not even on the weekends,\u201d he quipped.<\/p>\n

So Johnson enlisted the help of\u00a0Koenraad Van Doorslaer<\/strong>, an assistant professor of immunobiology and expert virologist in the\u00a0College of Agriculture and Life Sciences<\/a>.\u00a0Wei Wang<\/strong>, a professor of pharmacology and toxicology who creates the compounds they\u2019ll be testing, and\u00a0Elisa Tomat<\/strong>, an associate professor of chemistry and biochemistry who is an expert on metal ionophores, are advising Johnson and Van Doorslaer as they experiment.<\/p>\n

\"\"
Graphic by Eddie Canto\/RII<\/figcaption><\/figure>\n

\u201cMaking great things happen in science requires one fundamental thing, and that\u2019s the spirit of collaboration,\u201d said Johnson. \u201cWe all have different expertise, but we come together for a common purpose and we create something better than the sum of our parts.\u201d<\/p>\n

Johnson noted that he and Van Doorslaer\u00a0are not using SARS-CoV-2 samples to conduct their experiments.<\/p>\n

\u201cWe are using a virus that mimics the SARS-CoV-2 virus, but that will not cause disease. This is a powerful and safe way to identify drugs that could impact COVID-19,\u201d said Van Doorslaer, who teaches in the School of Animal and Comparative Biomedical Sciences. They\u2019re also using a different, seasonal coronavirus that is not as dangerous as SARS-CoV-2 to test copper\u2019s effect against other components of the virus.<\/p>\n

\u201cUltimately, if we\u2019re successful with our preliminary vetting, we will move forward with testing these compounds directly on SARS-CoV-2,\u201d said Johnson.<\/p>\n

If copper proves effective in the cellular battle against COVID-19, physicians could use already existing therapeutics in tandem with copper to deliver an extra punch of toxicity to the virus. \u201cThat\u2019s what makes this an experiment worth doing,\u201d said Johnson.<\/p>\n

UArizona Researchers Pivot to Tackle COVID-19<\/a><\/p>\n

News courtesy of Emily Litvack, The University of Arizona Research.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Our Alumnus Michael Johnson, PhD, assistant professor of immunobiology, will work with Koenraad Van Doorslaer, PhD assistant professor in the\u00a0College of Agriculture and Life Sciences,\u00a0at the University of Arizona – Health Sciences – College of Medicine to investigate the use of copper compounds in preventing infection. A team of UArizona Health Sciences researchers is studying … Read more<\/a><\/p>\n","protected":false},"author":86415,"featured_media":13686,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[22,298],"class_list":["post-13685","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_alum","tag-news_2020","odd"],"acf":[],"yoast_head":"\nIdentifying prevention or treatment strategies for COVID-19: Could Copper Disable the Virus Behind COVID-19? | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/identifying-prevention-or-treatment-strategies-for-covid-19-could-copper-disable-the-virus-behind-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identifying prevention or treatment strategies for COVID-19: Could Copper Disable the Virus Behind COVID-19? | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Our Alumnus Michael Johnson, PhD, assistant professor of immunobiology, will work with Koenraad Van Doorslaer, PhD assistant professor in the\u00a0College of Agriculture and Life Sciences,\u00a0at the University of Arizona – Health Sciences – College of Medicine to investigate the use of copper compounds in preventing infection. 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