{"id":14982,"date":"2020-08-10T09:15:32","date_gmt":"2020-08-10T13:15:32","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=14982"},"modified":"2020-08-10T15:02:44","modified_gmt":"2020-08-10T19:02:44","slug":"liu-lab-receives-a-nci-r01-grant","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/liu-lab-receives-a-nci-r01-grant\/","title":{"rendered":"Liu Lab receives a NCI R01 grant"},"content":{"rendered":"<figure id=\"attachment_4858\" class=\"thumbnail wp-caption alignleft\" style=\"width: 224px\"><a href=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-4858\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-214x300.jpg\" alt=\"photo of Pengda Liu PhD\" width=\"214\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-214x300.jpg 214w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-150x210.jpg 150w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-768x1075.jpg 768w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-731x1024.jpg 731w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-366x512.jpg 366w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg 1500w\" sizes=\"auto, (max-width: 214px) 100vw, 214px\" \/><\/a><figcaption class=\"caption wp-caption-text\">Pengda Liu PhD<\/figcaption><\/figure>\n<p>Liu lab received a NCI R01 grant to investigate novel function of cGAS in modulating breast cancer pathology. This five year grant will enable Liu lab to continue their current journey in investigation roles of innate immunity signaling in cancer.<\/p>\n<p>Project Title: Elucidating novel functions of cGAS in breast cancer<\/p>\n<p>NIH awarded a grant in the amount of $355,706.<\/p>\n<p>The Liu lab focuses on advancing the understanding of deregulated signaling events in contributing to tumorigenesis. The lab is interested in elucidating cancer specific regulatory mechanisms governing mTOR\/Akt and cGAS\/STING signaling, with goals to identify new drug targets and therapeutic directions.<\/p>\n<p>This awarded R01 will facilitate Liu lab investigations to further elucidate a special nuclear function of cGAS and validate in patient cohorts if it can be used as a new biomarker for diagnosis.<\/p>\n<p><a href=\"https:\/\/unclineberger.org\/pengdaliulab\/lab-members\/\">Pengda Liu lab<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Liu lab received a NCI R01 grant to investigate novel function of cGAS in modulating breast cancer pathology. This five year grant will enable Liu lab to continue their current journey in investigation roles of innate immunity signaling in cancer.<\/p>\n","protected":false},"author":41619,"featured_media":4858,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,298],"class_list":["post-14982","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2020","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Liu Lab receives a NCI R01 grant | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/liu-lab-receives-a-nci-r01-grant\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Liu Lab receives a NCI R01 grant | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Liu lab received a NCI R01 grant to investigate novel function of cGAS in modulating breast cancer pathology. This five year grant will enable Liu lab to continue their current journey in investigation roles of innate immunity signaling in cancer.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/liu-lab-receives-a-nci-r01-grant\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-10T13:15:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-10T19:02:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-731x1024.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"731\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/liu-lab-receives-a-nci-r01-grant\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/liu-lab-receives-a-nci-r01-grant\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"Liu Lab receives a NCI R01 grant\",\"datePublished\":\"2020-08-10T13:15:32+00:00\",\"dateModified\":\"2020-08-10T19:02:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/liu-lab-receives-a-nci-r01-grant\/\"},\"wordCount\":154,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/liu-lab-receives-a-nci-r01-grant\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg\",\"keywords\":[\"Faculty &amp; 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