{"id":16550,"date":"2021-01-25T08:00:31","date_gmt":"2021-01-25T13:00:31","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=16550"},"modified":"2021-01-25T16:08:44","modified_gmt":"2021-01-25T21:08:44","slug":"how-an-error-prone-dna-repair-pathway-scars-the-genome","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/","title":{"rendered":"How an error-prone DNA repair pathway scars the genome"},"content":{"rendered":"<figure id=\"attachment_16551\" class=\"thumbnail wp-caption alignright\" style=\"width: 235px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-16551\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020-225x300.jpg\" alt=\"Juan Carvajal-Garcia\" width=\"225\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020-225x300.jpg 225w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020-768x1024.jpg 768w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020-1152x1536.jpg 1152w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020-600x800.jpg 600w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg 1200w\" sizes=\"auto, (max-width: 225px) 100vw, 225px\" \/><figcaption class=\"caption wp-caption-text\">Juan Carvajal-Garcia, PhD candidate in Ramsden lab<\/figcaption><\/figure>\n<div class=\"well   oscitas-bootstrap-container \">Juan Carvajal-Garcia, PhD candidate in Ramsden lab published research in PNAS.<\/div>\n<p>Chromosome breaks are a serious threat to the stability of the genome, and when left unrepaired can cause cell death. DNA Polymerase Theta (Pol \u03b8) is central to a chromosome break repair pathway that is rarely used in normal cells but is hyperactive in certain cancers. Because some breast and ovarian tumors rely on Pol \u03b8 for survival, it is a promising therapeutic target against these tumors<i>.<\/i>\u00a0Pol \u03b8 has to find short, complementary sequences in the DNA. In this paper, we show how it scans<i>\u00a0<\/i>the DNA to find them in a way that minimizes the loss of DNA. If these complementary sequences are not present, Pol \u03b8 creates them, generating new DNA sequences that we call templated insertions. Templated insertions are a very characteristic type of mutation, that we demonstrated is common in breast tumors with mutations in BRCA1 and BRCA2, as well as tumors that overexpress Pol \u03b8<b>.\u00a0<\/b>We propose that looking for templated insertions in the genomes of breast and ovarian tumors is a way to assess whether this protein is active, which would make the tumor sensitive to a drug that targets Pol \u03b8.<\/p>\n<p id=\"page-title\" class=\"highwire-cite-title\"><a href=\"https:\/\/www.pnas.org\/content\/117\/15\/8476\">Mechanistic basis for microhomology identification and genome scarring by polymerase theta<\/a> link to publication.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Juan Carvajal-Garcia, PhD candidate in Ramsden lab published research in PNAS.<\/p>\n","protected":false},"author":41619,"featured_media":16551,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[363,13],"class_list":["post-16550","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_2021","tag-news_students","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How an error-prone DNA repair pathway scars the genome | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How an error-prone DNA repair pathway scars the genome | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Juan Carvajal-Garcia, PhD candidate in Ramsden lab published research in PNAS.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-25T13:00:31+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-01-25T21:08:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"1600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"How an error-prone DNA repair pathway scars the genome\",\"datePublished\":\"2021-01-25T13:00:31+00:00\",\"dateModified\":\"2021-01-25T21:08:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/\"},\"wordCount\":235,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg\",\"keywords\":[\"News 2021\",\"Student News\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/\",\"name\":\"How an error-prone DNA repair pathway scars the genome | Biochemistry and Biophysics\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg\",\"datePublished\":\"2021-01-25T13:00:31+00:00\",\"dateModified\":\"2021-01-25T21:08:44+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg\",\"width\":1200,\"height\":1600,\"caption\":\"Juan Carvajal-Garcia, PhD Ramsden &amp; Sekelsky labs\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/biochem\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"How an error-prone DNA repair pathway scars the genome\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"name\":\"UNC Biochemistry and Biophysics\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\",\"name\":\"UNC Department of Biochemistry and Biophysics\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"width\":488,\"height\":400,\"caption\":\"UNC Department of Biochemistry and Biophysics\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\",\"https:\/\/x.com\/UNC_BCBP\",\"https:\/\/www.instagram.com\/unc_bcbp\/\",\"https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\",\"name\":\"Carolyn Clabo\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"caption\":\"Carolyn Clabo\"},\"description\":\"Biochemistry &amp; Biophysics - Communications &amp; Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology &amp; Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement &amp; Univ. Development (former)\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"How an error-prone DNA repair pathway scars the genome | Biochemistry and Biophysics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/","og_locale":"en_US","og_type":"article","og_title":"How an error-prone DNA repair pathway scars the genome | Biochemistry and Biophysics","og_description":"Juan Carvajal-Garcia, PhD candidate in Ramsden lab published research in PNAS.","og_url":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/","og_site_name":"Biochemistry and Biophysics","article_publisher":"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","article_published_time":"2021-01-25T13:00:31+00:00","article_modified_time":"2021-01-25T21:08:44+00:00","og_image":[{"width":1200,"height":1600,"url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg","type":"image\/jpeg"}],"author":"Carolyn Clabo","twitter_card":"summary_large_image","twitter_creator":"@UNC_BCBP","twitter_site":"@UNC_BCBP","twitter_misc":{"Written by":"Carolyn Clabo","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/"},"author":{"name":"Carolyn Clabo","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332"},"headline":"How an error-prone DNA repair pathway scars the genome","datePublished":"2021-01-25T13:00:31+00:00","dateModified":"2021-01-25T21:08:44+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/"},"wordCount":235,"publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg","keywords":["News 2021","Student News"],"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/","url":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/","name":"How an error-prone DNA repair pathway scars the genome | Biochemistry and Biophysics","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg","datePublished":"2021-01-25T13:00:31+00:00","dateModified":"2021-01-25T21:08:44+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#primaryimage","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg","width":1200,"height":1600,"caption":"Juan Carvajal-Garcia, PhD Ramsden &amp; Sekelsky labs"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/how-an-error-prone-dna-repair-pathway-scars-the-genome\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/biochem\/"},{"@type":"ListItem","position":2,"name":"How an error-prone DNA repair pathway scars the genome"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/biochem\/#website","url":"https:\/\/www.med.unc.edu\/biochem\/","name":"UNC Biochemistry and Biophysics","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/biochem\/#organization","name":"UNC Department of Biochemistry and Biophysics","url":"https:\/\/www.med.unc.edu\/biochem\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","width":488,"height":400,"caption":"UNC Department of Biochemistry and Biophysics"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","https:\/\/x.com\/UNC_BCBP","https:\/\/www.instagram.com\/unc_bcbp\/","https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/"]},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332","name":"Carolyn Clabo","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","caption":"Carolyn Clabo"},"description":"Biochemistry &amp; Biophysics - Communications &amp; Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology &amp; Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement &amp; Univ. Development (former)","url":"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020-225x300.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020-768x1024.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020-768x1024.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/Juan-Carvajal-Garcia-2020-150x150.jpg","featured_image_alt":"Juan Carvajal-Garcia","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/biochem\/category\/news\/"}],"tag_details":[{"name":"News 2021","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_2021\/"},{"name":"Student News","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_students\/"}],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/16550","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/users\/41619"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/comments?post=16550"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/16550\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media\/16551"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media?parent=16550"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/categories?post=16550"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/tags?post=16550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}