{"id":16743,"date":"2020-10-06T15:16:15","date_gmt":"2020-10-06T19:16:15","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=16743"},"modified":"2021-05-18T12:05:38","modified_gmt":"2021-05-18T16:05:38","slug":"graduate-student-cathy-spangler-in-mcginty-lab-uses-cryo-em-to-determine-structure-of-cgas","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/graduate-student-cathy-spangler-in-mcginty-lab-uses-cryo-em-to-determine-structure-of-cgas\/","title":{"rendered":"Graduate Student Cathy Spangler in McGinty lab uses cryo-EM to determine structure of cGAS"},"content":{"rendered":"<p><a href=\"https:\/\/biophysics.unc.edu\/wp-content\/uploads\/sites\/23230\/2020\/10\/IMG_6961_8x10-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1055 alignleft\" src=\"https:\/\/biophysics.unc.edu\/wp-content\/uploads\/sites\/23230\/2020\/10\/IMG_6961_8x10-scaled.jpg\" alt=\"Cathy Anderson\" width=\"248\" height=\"311\" \/><\/a>Biochemistry and biophysics PhD student, Cathy Spangler, researches in\u00a0<a href=\"https:\/\/pharmacy.unc.edu\/directory\/rmcginty\/\">Robert McGinty\u2019s lab<\/a>\u00a0and recently published a paper in collaboration with Joshua Boyer, Joshua Strauss, Andrew Cesmat, Pengda Liu, Robert McGinty, and Qi Zhang, titled\u00a0<em><a href=\"https:\/\/science.sciencemag.org\/content\/early\/2020\/09\/09\/science.abd0609\">Structural basis of nucleosome-dependent cGAS inhibition<\/a>.\u00a0<\/em>This article addresses the use of cryo-electron microscopy to determine the high-resolution structure of a DNA-sensing protein called cGAS\u00a0bound to the nucleosome \u2013 the fundamental repeating unit of chromatin. A key sensor in our body\u2019s innate immune system, cGAS detects foreign or damaged DNA and triggers the body\u2019s response against infected or cancerous cells. This work reveals molecular details about how the nucleosome binds to cGAS and inhibits it from mistakenly triggering an autoimmune response to our own healthy DNA. Cathy\u2019s\u00a0research aims to visualize key protein interactions in the nucleus at near-atomic resolution. Many of these proteins, such as cGAS, are dysfunctional in cancers and autoimmune diseases. Discovering the structural details about how these proteins function helps researchers identify new strategies for drug development.<\/p>\n<p>This paper was published online by the journal\u00a0<em>Science<\/em>\u00a0in September 2020.\u00a0<a href=\"https:\/\/science.sciencemag.org\/content\/early\/2020\/09\/09\/science.abd0609\">DOI: 10.1126\/science.abd0609<\/a><\/p>\n<p>Read the School of Medicine highlight here <a href=\"https:\/\/news.unchealthcare.org\/2020\/09\/researchers-reveal-safeguarding-of-a-key-dna-sensor-in-the-innate-immune-system\/?utm_source=vs-email&amp;utm_medium=email&amp;utm_campaign=37\">Researchers Reveal Safeguarding of a Key DNA Sensor in the Innate Immune System<\/a><\/p>\n<p>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cathy Spangler published a paper in collaboration with Joshua Boyer, Joshua Strauss, Andrew Cesmat, Pengda Liu, Robert McGinty, and Qi Zhang, titled &#8220;Structural basis of nucleosome-dependent cGAS inhibition.&#8221;<\/p>\n","protected":false},"author":41619,"featured_media":16744,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[298,13],"class_list":["post-16743","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_2020","tag-news_students","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Graduate Student Cathy Spangler in McGinty lab uses cryo-EM to determine structure of cGAS | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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