{"id":16782,"date":"2021-01-15T10:58:16","date_gmt":"2021-01-15T15:58:16","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=16782"},"modified":"2021-02-09T11:02:42","modified_gmt":"2021-02-09T16:02:42","slug":"michelle-potter-birriel-grad-student-in-marzluff-lab-publishes-paper-in-journal-of-cell-science","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/michelle-potter-birriel-grad-student-in-marzluff-lab-publishes-paper-in-journal-of-cell-science\/","title":{"rendered":"Michelle Potter-Birriel grad student in Marzluff lab publishes paper in Journal of Cell Science"},"content":{"rendered":"<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-14296 alignright\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2020\/05\/Jennifer-M-P-B-June-3-2020-Marzluff-lab-234x300.png\" alt=\"Jennifer Michelle Potter-Birriel\" width=\"234\" height=\"300\" \/><\/strong>Michelle Potter-Birriel\u00a0(<a href=\"https:\/\/bio.unc.edu\/faculty-profile\/marzluff\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><em>Bill Marzluff\u00a0<\/em>lab<\/strong><\/a>) published an article titled \u201cA region of SLBP outside the mRNA processing domain is essential for deposition of histone mRNA into the\u00a0<em>Drosophila<\/em>\u00a0egg\u201d in\u00a0<em><a href=\"https:\/\/jcs.biologists.org\/content\/early\/2021\/01\/05\/jcs.251728\" target=\"_blank\" rel=\"noopener noreferrer\">Journal of Cell Science\u00a0<\/a><\/em>(<a href=\"https:\/\/doi.org\/10.1242\/jcs.251728\" target=\"_blank\" rel=\"noopener noreferrer\">DOI: 10.1242\/jcs.251728<\/a>). Jan. 06, 2021<\/p>\n<figure id=\"attachment_16783\" class=\"thumbnail wp-caption aligncenter\" style=\"width: 726px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-16783 size-full\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/02\/scientific-image-for-Marzluff-lab-pub.png\" alt=\"scientific image: SLBP (green; DNA in magenta) in Drosophila egg chambers of wild-type (top) and SLBP mutant (bottom) (click to enlarge; see article for details)\" width=\"716\" height=\"598\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/02\/scientific-image-for-Marzluff-lab-pub.png 716w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/02\/scientific-image-for-Marzluff-lab-pub-300x251.png 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/02\/scientific-image-for-Marzluff-lab-pub-600x501.png 600w\" sizes=\"auto, (max-width: 716px) 100vw, 716px\" \/><figcaption class=\"caption wp-caption-text\">mage: SLBP (green; DNA in magenta) in Drosophila egg chambers of wild-type (top) and SLBP mutant (bottom) (click to enlarge; see article for details).<\/figcaption><\/figure>\n<h2>Abstract<\/h2>\n<p id=\"p-1\">Replication-dependent histone mRNAs are the only cellular mRNAs that are not polyadenylated, ending in a stemloop instead of a polyA tail, and are normally regulated coordinately with DNA replication. SLBP binds the 3\u2019 end of histone mRNA, and is required for processing and translation. During\u00a0<em>Drosophila<\/em>\u00a0oogenesis, large amounts of histone mRNAs and proteins are deposited in the developing oocyte.The maternally deposited histone mRNA is synthesized in stage 10B oocytes after the nurse cells complete endoreduplication. We report that in WT stage 10B oocytes, the Histone Locus Bodies (HLBs), formed on the histone genes, produce histone mRNAs in the absence of phosphorylation of Mxc, normally required for histone gene expression in S-phase cells. Two mutants of SLBP, one with reduced expression and another with a 10 aa deletion, fail to deposit sufficient histone mRNA in the oocyte, and don&#8217;t transcribe the histone genes in stage 10B. Mutations in a putative SLBP nuclear localization sequence overlapping the deletion, phenocopy the deletion. We conclude a high concentration of SLBP in the nucleus of stage 10B oocytes is essential for histone gene transcription.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Michelle Potter-Birriel\u00a0(Bill Marzluff\u00a0lab) published an article titled \u201cA region of SLBP outside the mRNA processing domain is essential for deposition of histone mRNA into the\u00a0Drosophila\u00a0egg\u201d in\u00a0Journal of Cell Science\u00a0(DOI: 10.1242\/jcs.251728). Jan. 06, 2021 Abstract Replication-dependent histone mRNAs are the only cellular mRNAs that are not polyadenylated, ending in a stemloop instead of a polyA tail, &hellip; <a href=\"https:\/\/www.med.unc.edu\/biochem\/news\/michelle-potter-birriel-grad-student-in-marzluff-lab-publishes-paper-in-journal-of-cell-science\/\" aria-label=\"Read more about Michelle Potter-Birriel grad student in Marzluff lab publishes paper in Journal of Cell Science\">Read more<\/a><\/p>\n","protected":false},"author":41619,"featured_media":16783,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[363,13],"class_list":["post-16782","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_2021","tag-news_students","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Michelle Potter-Birriel grad student in Marzluff lab publishes paper in Journal of Cell Science | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/michelle-potter-birriel-grad-student-in-marzluff-lab-publishes-paper-in-journal-of-cell-science\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Michelle Potter-Birriel grad student in Marzluff lab publishes paper in Journal of Cell Science | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Michelle Potter-Birriel\u00a0(Bill Marzluff\u00a0lab) published an article titled \u201cA region of SLBP outside the mRNA processing domain is essential for deposition of histone mRNA into the\u00a0Drosophila\u00a0egg\u201d in\u00a0Journal of Cell Science\u00a0(DOI: 10.1242\/jcs.251728). Jan. 06, 2021 Abstract Replication-dependent histone mRNAs are the only cellular mRNAs that are not polyadenylated, ending in a stemloop instead of a polyA tail, &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/michelle-potter-birriel-grad-student-in-marzluff-lab-publishes-paper-in-journal-of-cell-science\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-15T15:58:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-02-09T16:02:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/02\/scientific-image-for-Marzluff-lab-pub.png\" \/>\n\t<meta property=\"og:image:width\" content=\"716\" \/>\n\t<meta property=\"og:image:height\" content=\"598\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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