{"id":18018,"date":"2021-02-20T11:58:59","date_gmt":"2021-02-20T16:58:59","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=18018"},"modified":"2021-05-18T12:01:57","modified_gmt":"2021-05-18T16:01:57","slug":"2021-multiple-cores-contribute-to-sars-cov-2-paper-published-in-nature","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/2021-multiple-cores-contribute-to-sars-cov-2-paper-published-in-nature\/","title":{"rendered":"2021: Multiple Cores Contribute to SARS-CoV-2 Paper Published in Nature"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-18019\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/05\/SARS-CoV-2-Paper-Published-in-Nature-Feb-2021-300x231.jpg\" alt=\"4 scientific images SARS-CoV-2 Paper Published in Nature\" width=\"300\" height=\"231\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/05\/SARS-CoV-2-Paper-Published-in-Nature-Feb-2021-300x231.jpg 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/05\/SARS-CoV-2-Paper-Published-in-Nature-Feb-2021-600x463.jpg 600w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/05\/SARS-CoV-2-Paper-Published-in-Nature-Feb-2021-560x432.jpg 560w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/05\/SARS-CoV-2-Paper-Published-in-Nature-Feb-2021.jpg 664w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>The Nature Accelerated Article Preview \u201c<a href=\"https:\/\/www.nature.com\/articles\/s41586-021-03312-w#Sec23\">SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801<\/a>\u201d was published online 09 FEB 2021. \u00a0Co-first authors Angela Wahl and Lisa E. Gralinski used a human lung-only mouse model to show that therapeutic and prophylactic administration of EIDD-2801, an oral broad spectrum antiviral currently in phase II\u2013III clinical trials, dramatically inhibited SARS-CoV-2 replication in vivo and thus has significant potential for the prevention and treatment of COVID-19.\u00a0 UNC core laboratories that contributed to this study include\u00a0<a href=\"https:\/\/www.med.unc.edu\/animalpathlab\/\">Animal Histopathology and Lab Medicine<\/a>, Bioinformatics and Analytics Research Collaborative (<a href=\"https:\/\/www.med.unc.edu\/barc\/\">BARC<\/a>),\u00a0<a href=\"https:\/\/www.med.unc.edu\/genomics\">High-Throughput Sequencing Facility<\/a>,\u00a0<a href=\"http:\/\/unccfar.org\/portfolio\/biostatistics\/\">CFAR Biostatistics Core<\/a>, and the\u00a0<a href=\"https:\/\/www.med.unc.edu\/microscopy\/\">Microscopy Services Laboratory<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Nature Accelerated Article Preview \u201cSARS-CoV-2 infection is effectively treated and prevented by EIDD-2801\u201d was published online 09 FEB 2021. \u00a0Co-first authors Angela Wahl and Lisa E. Gralinski used a human lung-only mouse model to show that therapeutic and prophylactic administration of EIDD-2801, an oral broad spectrum antiviral currently in phase II\u2013III clinical trials, dramatically &hellip; <a href=\"https:\/\/www.med.unc.edu\/biochem\/news\/2021-multiple-cores-contribute-to-sars-cov-2-paper-published-in-nature\/\" aria-label=\"Read more about 2021: Multiple Cores Contribute to SARS-CoV-2 Paper Published in Nature\">Read more<\/a><\/p>\n","protected":false},"author":41619,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,363],"class_list":["post-18018","post","type-post","status-publish","format-standard","hentry","category-news","tag-news_faculty","tag-news_2021","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>2021: Multiple Cores Contribute to SARS-CoV-2 Paper Published in Nature | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/2021-multiple-cores-contribute-to-sars-cov-2-paper-published-in-nature\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"2021: Multiple Cores Contribute to SARS-CoV-2 Paper Published in Nature | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"The Nature Accelerated Article Preview \u201cSARS-CoV-2 infection is effectively treated and prevented by EIDD-2801\u201d was published online 09 FEB 2021. \u00a0Co-first authors Angela Wahl and Lisa E. Gralinski used a human lung-only mouse model to show that therapeutic and prophylactic administration of EIDD-2801, an oral broad spectrum antiviral currently in phase II\u2013III clinical trials, dramatically &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/2021-multiple-cores-contribute-to-sars-cov-2-paper-published-in-nature\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-20T16:58:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-05-18T16:01:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/05\/SARS-CoV-2-Paper-Published-in-Nature-Feb-2021-300x231.jpg\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/2021-multiple-cores-contribute-to-sars-cov-2-paper-published-in-nature\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/2021-multiple-cores-contribute-to-sars-cov-2-paper-published-in-nature\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"2021: Multiple Cores Contribute to SARS-CoV-2 Paper Published in Nature\",\"datePublished\":\"2021-02-20T16:58:59+00:00\",\"dateModified\":\"2021-05-18T16:01:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/2021-multiple-cores-contribute-to-sars-cov-2-paper-published-in-nature\/\"},\"wordCount\":111,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/2021-multiple-cores-contribute-to-sars-cov-2-paper-published-in-nature\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/05\/SARS-CoV-2-Paper-Published-in-Nature-Feb-2021-300x231.jpg\",\"keywords\":[\"Faculty &amp; 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