{"id":18311,"date":"2021-06-03T14:48:05","date_gmt":"2021-06-03T18:48:05","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=18311"},"modified":"2021-06-18T11:04:23","modified_gmt":"2021-06-18T15:04:23","slug":"researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/","title":{"rendered":"Researchers discover gene linked to bone cancer in children, identify potential novel therapy"},"content":{"rendered":"<p>Researchers have discovered a gene,\u00a0<em>OTUD7A<\/em>, that impacts the development of Ewing sarcoma, a bone cancer that occurs mainly in children. They have also identified a compound that shows potential to block OTUD7A protein activity. The finding, by scientists at the University of North Carolina and the Lineberger Comprehensive Cancer Center, appeared online June 1, 2021, in\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/advs.202004846\"><em>Advanced Science<\/em><\/a><em>.\u00a0<\/em><\/p>\n<p>About 250 children and young adults are diagnosed with Ewing sarcoma each year in the U.S. About half of those diagnosed will ultimately succumb to the disease, pointing to the need for better therapies.<\/p>\n<figure id=\"attachment_13899\" class=\"thumbnail wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-13899\" src=\"https:\/\/unclineberger.org\/wp-content\/uploads\/sites\/867\/2018\/10\/Pengda-Liu-731x1024.jpg\" alt=\"Caption available\" width=\"285\" height=\"399\" \/><figcaption class=\"caption wp-caption-text\">Pengda Liu, PhD, assistant professor<\/figcaption><\/figure>\n<p>\u201cOur primary research focus targeted the EWS-FLI1 fusion protein found in about 85 percent of Ewing sarcoma patients,\u201d said UNC Lineberger\u2019s\u00a0<a href=\"https:\/\/unclineberger.org\/directory\/pengda-liu\/\">Pengda Liu, PhD,<\/a>\u00a0assistant professor of Biochemistry and Biophysics in the UNC School of Medicine and co-lead author. \u201cThis protein, made up of pieces of two other proteins, is unique to Ewing sarcoma and only produced in cancer cells, making it an excellent target for treatment.\u201d<\/p>\n<p>Critical relationships between proteins contribute to the development of cancers such as Ewing sarcoma. So, it was a seminal discovery when the UNC researchers found that OTUD7A controls the cancer-causing fusion protein.<\/p>\n<p>Armed with this knowledge, the scientists went on the hunt for small molecule compounds that could block OTUD7A\u2019s activity. Their collaborator, Atomwise Inc., used an artificial intelligence program known as AtomNet to screen four million small molecules to find ones that could fit into a pocket in OTUD7A. One compound they identified, 7Ai, showed a good ability to reduce tumor formation in mice that were grafted with human Ewing sarcoma cells. The compound did not appear to be toxic and was well-tolerated. Also, 7Ai did not kill normal cells that were tested in lab culture experiments.<\/p>\n<p>\u201cTreatment with 7Ai could provide a new targeted therapeutic option for patients who become resistant to chemotherapy. Developing an effective drug will require more lab work and then clinical studies, however,\u201d said Liu.<\/p>\n<figure id=\"attachment_13616\" class=\"thumbnail wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-13616\" src=\"https:\/\/unclineberger.org\/wp-content\/uploads\/sites\/867\/2018\/10\/Davis-Ian-770x1024.jpg\" alt=\"Caption available\" width=\"285\" height=\"379\" \/><figcaption class=\"caption wp-caption-text\">UNC Lineberger\u2019s Ian Davis, MD, PhD.<\/figcaption><\/figure>\n<p>\u201cBy deeply exploring the key cellular processes that lead to cancer, unexpected potential therapeutic avenues can result,\u201d said co-author\u00a0<a href=\"https:\/\/unclineberger.org\/directory\/ian-davis\/\">Ian Davis, MD, PhD<\/a>, G. Denman Hammond Professor of Childhood Cancer and co-leader of the Cancer Genetics Program at UNC Lineberger. \u201cOnce the basic science validated our biological approaches, the application of computational virtual screening enabled us to quickly identify a lead molecule for further testing and validation.\u201d<\/p>\n<p>The researchers are currently working with the UNC Eshelman School of Pharmacy to improve 7Ai\u2019s potency and specificity.<\/p>\n<p>\u201cI am particularly indebted to a UNC student with metastatic Ewing sarcoma who made it a priority to donate tissue that could be used for research,\u201d said Davis, who is also the associate division chief of pediatric hematology-oncology. \u201cWe\u2019re also appreciative of funding for our research through an NIH Beau Biden Pediatric Cancer Moonshot grant, which came about after the cancer-related death of President Biden\u2019s son.\u201d<\/p>\n<h4>Authors and disclosures<\/h4>\n<p>In addition to Liu and Davis, the paper\u2019s other authors at UNC include Siyuan Su, PhD, Jianfeng Chen, PhD, Yao Jiang, Ying Wang, PhD, Tamara Vital, Jiaming Zhang, MD, Zhichuan Zhu, PhD, Alex W. Prevatte, Natalie K. Barker, and Laura E. Herring, PhD. Christian Laggner and Kong T. Nguyen are at Atomwise Inc., San Francisco.<\/p>\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/advs.202004846\"><em>&#8220;<\/em><i>SPOP<\/i>\u00a0and\u00a0<i>OTUD7A<\/i>\u00a0Control\u00a0<i>EWS\u2013FLI1<\/i> Protein Stability to Govern Ewing Sarcoma Growth&#8221; <em>Advanced Science<\/em><\/a><\/p>\n<p>This work was supported by NIH grants (R21CA234979 and R01CA244825), an Atomwise AIMS Award (A17-034), a V Scholar Grant (V2018-009), a Breast Cancer Alliance Young Investigator Grant, a Gabrielle\u2019s Angel Foundation Medical Research Award, a UNC Lineberger Comprehensive Cancer Center Development Award and the University Cancer Research Fund. This research is based in part on work conducted using the UNC Proteomics Core Facility, which is supported in part by a P30 CA016086 Cancer Center Core Support Grant to UNC Lineberger.<\/p>\n<p><em>News courtesy of Lineberger Communications.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pengda Liu, PhD, and colleagues have discovered a gene, OTUD7A, that impacts the development of Ewing sarcoma, a bonecancer that occurs mainly in children, as well as a compound that shows potential to block OTUD7A protein activity.<\/p>\n","protected":false},"author":41619,"featured_media":4858,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,363],"class_list":["post-18311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2021","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Researchers discover gene linked to bone cancer in children, identify potential novel therapy | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers discover gene linked to bone cancer in children, identify potential novel therapy | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Pengda Liu, PhD, and colleagues have discovered a gene, OTUD7A, that impacts the development of Ewing sarcoma, a bonecancer that occurs mainly in children, as well as a compound that shows potential to block OTUD7A protein activity.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-03T18:48:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-06-18T15:04:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-731x1024.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"731\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"Researchers discover gene linked to bone cancer in children, identify potential novel therapy\",\"datePublished\":\"2021-06-03T18:48:05+00:00\",\"dateModified\":\"2021-06-18T15:04:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/\"},\"wordCount\":669,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg\",\"keywords\":[\"Faculty &amp; Lab News\",\"News 2021\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/\",\"name\":\"Researchers discover gene linked to bone cancer in children, identify potential novel therapy | Biochemistry and Biophysics\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg\",\"datePublished\":\"2021-06-03T18:48:05+00:00\",\"dateModified\":\"2021-06-18T15:04:23+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg\",\"width\":1500,\"height\":2100,\"caption\":\"Pengda Liu PhD, Associate Professor\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/biochem\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Researchers discover gene linked to bone cancer in children, identify potential novel therapy\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"name\":\"UNC Biochemistry and Biophysics\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\",\"name\":\"UNC Department of Biochemistry and Biophysics\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"width\":488,\"height\":400,\"caption\":\"UNC Department of Biochemistry and Biophysics\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\",\"https:\/\/x.com\/UNC_BCBP\",\"https:\/\/www.instagram.com\/unc_bcbp\/\",\"https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\",\"name\":\"Carolyn Clabo\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"caption\":\"Carolyn Clabo\"},\"description\":\"Biochemistry &amp; Biophysics - Communications &amp; Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology &amp; Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement &amp; Univ. Development (former)\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Researchers discover gene linked to bone cancer in children, identify potential novel therapy | Biochemistry and Biophysics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/","og_locale":"en_US","og_type":"article","og_title":"Researchers discover gene linked to bone cancer in children, identify potential novel therapy | Biochemistry and Biophysics","og_description":"Pengda Liu, PhD, and colleagues have discovered a gene, OTUD7A, that impacts the development of Ewing sarcoma, a bonecancer that occurs mainly in children, as well as a compound that shows potential to block OTUD7A protein activity.","og_url":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/","og_site_name":"Biochemistry and Biophysics","article_publisher":"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","article_published_time":"2021-06-03T18:48:05+00:00","article_modified_time":"2021-06-18T15:04:23+00:00","og_image":[{"width":731,"height":1024,"url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-731x1024.jpg","type":"image\/jpeg"}],"author":"Carolyn Clabo","twitter_card":"summary_large_image","twitter_creator":"@UNC_BCBP","twitter_site":"@UNC_BCBP","twitter_misc":{"Written by":"Carolyn Clabo","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/"},"author":{"name":"Carolyn Clabo","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332"},"headline":"Researchers discover gene linked to bone cancer in children, identify potential novel therapy","datePublished":"2021-06-03T18:48:05+00:00","dateModified":"2021-06-18T15:04:23+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/"},"wordCount":669,"publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg","keywords":["Faculty &amp; Lab News","News 2021"],"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/","url":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/","name":"Researchers discover gene linked to bone cancer in children, identify potential novel therapy | Biochemistry and Biophysics","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg","datePublished":"2021-06-03T18:48:05+00:00","dateModified":"2021-06-18T15:04:23+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#primaryimage","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg","width":1500,"height":2100,"caption":"Pengda Liu PhD, Associate Professor"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-discover-gene-linked-to-bone-cancer-in-children-identify-potential-novel-therapy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/biochem\/"},{"@type":"ListItem","position":2,"name":"Researchers discover gene linked to bone cancer in children, identify potential novel therapy"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/biochem\/#website","url":"https:\/\/www.med.unc.edu\/biochem\/","name":"UNC Biochemistry and Biophysics","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/biochem\/#organization","name":"UNC Department of Biochemistry and Biophysics","url":"https:\/\/www.med.unc.edu\/biochem\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","width":488,"height":400,"caption":"UNC Department of Biochemistry and Biophysics"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","https:\/\/x.com\/UNC_BCBP","https:\/\/www.instagram.com\/unc_bcbp\/","https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/"]},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332","name":"Carolyn Clabo","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","caption":"Carolyn Clabo"},"description":"Biochemistry &amp; Biophysics - Communications &amp; Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology &amp; Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement &amp; Univ. Development (former)","url":"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-214x300.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-768x1075.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-731x1024.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/Liu_Pengda-150x210.jpg","featured_image_alt":"photo of Pengda Liu PhD","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/biochem\/category\/news\/"}],"tag_details":[{"name":"Faculty &amp; Lab News","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_faculty\/"},{"name":"News 2021","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_2021\/"}],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/18311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/users\/41619"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/comments?post=18311"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/18311\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media\/4858"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media?parent=18311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/categories?post=18311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/tags?post=18311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}