![\"Brian](\"https:\/\/thewell.unc.edu\/wp-content\/uploads\/sites\/1007\/2021\/06\/convergent_code.jpg\")
An interdisciplinary team of Carolina scientists is rewriting faulty instructions in genomes to treat genetic diseases without changing the DNA itself.<\/p>\nAn interdisciplinary team of Carolina scientists is rewriting faulty instructions in genomes to treat genetic diseases without changing the DNA itself.<\/p>\n
When you hear \u201cDNA,\u201d what normally comes to mind? If you\u2019re like most, your brain fires up the image of the twisted, two-fold ladder we all remember from science class. What might not be as familiar as the double helix \u2014 but which proves to be at least as fascinating \u2014 is epigenetics, the study of hereditary changes that occur in our genome that do not involve changes to our genetic code.<\/p>\n
The growing field of epigenetics holds the promise of future treatments for those facing cancer and rare diseases. Yet at the University of North Carolina at Chapel Hill, it\u2019s not just the breakthrough potential of the field itself that\u2019s exciting. It\u2019s also how researchers from different departments are teaming up to push the science further and faster than they could do alone.<\/p>\n
Brian Strahl<\/a>, interim chair and professor of biochemistry and biophysics at the UNC School of Medicine, and\u00a0Samantha Pattenden<\/a>, associate professor at the Eshelman School of Pharmacy, are combining their expertise in chemical biology and epigenetics through a collaboration known as the Chemical Epigenomics Hub. Their common goal: identify, develop and apply chemical tools to better understand epigenetic processes, ultimately improving the treatment of human disease.<\/p>\n Brian Strahl (Image courtesy of Innovate Carolina)<\/p>\n<\/div>\n \u201cThe hub allows us to combine our multidisciplinary talents and strengths to do things that no one individual could do,\u201d says Strahl. \u201cAt UNC, we are primed for collaborative endeavors, and the hub gives us the opportunity to come together and think about new areas of science.\u201d<\/p>\n \u201cThe idea of convergent science, where we can have all these different fields coming together to be efficient with a project, is a great concept. It\u2019s something we just naturally do here at UNC,\u201d adds Pattenden.<\/p>\n Strahl\u2019s and Pattenden\u2019s research is focused on the epigenome, which is an additional layer of genetic information that controls the \u201cwhen and where\u201d of how our genes are used. The epigenome controls DNA access, and when this system malfunctions, problems in the human body can arise.<\/p>\n \u201cWhile epigenetics controls our normal development, we have also learned that its malfunction, just like a mutation of our DNA, can lead to disease,\u201d says Strahl. \u201cExcitingly, however, unlike mutations to the DNA sequence, changes in the epigenome are reversible. This plasticity makes the epigenome a fantastic target for therapeutic development.\u201d<\/p>\n Histones \u2014 proteins that provide structural support to a chromosome \u2014 can mutate, leading to bone cancers or devastating pediatric brain cancers, which currently have limited treatments available. Strahl, Pattenden and the Chemical Epigenomics Hub team are focusing their work on these histones and the mutant forms called onco-histones that drive cancer. The hub will deliver a new understanding of how onco-histones contribute to the epigenome and will define new pathways and targets.<\/p>\n \u201cAbout half of all cancers have mutations in the machinery involved with epigenetics,\u201d says Strahl. \u201cThrough epigenetic chemical screens, we are working to identify new avenues or approaches that could lead us down a path toward identification of a pathway or particular drug that could be useful in treatment.\u201d<\/p>\n Samantha Pattenden (Image courtesy of Innovate Carolina)<\/p>\n<\/div>\n \u201cThe advantage of epigenetics is that we don\u2019t have to manipulate the genome,\u201d adds Pattenden. \u201cEpigenetics, unlike genetic mutations, are reversible. We can do things without actually changing the underlying DNA sequence.\u201d<\/p>\n Breakthroughs in epigenetics require teams with specialized skills, and the Chemical Epigenomics Hub brings necessary talents together from across campus. These include experts in epigenomics, model organisms, genomics, proteomics, chemistry and chemical biology.<\/p>\n The hub\u2019s multidisciplinary foundation provides opportunities for Strahl and Pattenden to collaborate with researchers from the Center for Integrative Chemical Biology and Drug Discovery and more than 12 epigenetics laboratories, including labs from the medical and pharmacy schools, the Lineberger Comprehensive Cancer Center and the College of Arts & Sciences. And hub members don\u2019t just hail from Chapel Hill. The team includes researchers from the Baylor College of Medicine and the University of Alabama as well.<\/p>\n Briah Strahl and Julia Flynn, lab assistant,<\/a> count and examine cell cultures in his lab. (Image courtesy of Innovate Carolina)<\/p>\n<\/div>\n \u201cDifferent disciplines have different toolkits for addressing questions and problems in cellular and genomic research,\u201d says\u00a0J. Christopher Clemens<\/a>, senior associate dean for research and innovation at the College of Arts & Sciences. \u201cThe amazing thing for me about this project has been watching how the team\u2019s combined toolkit has worked in harmony to enlarge the scope of the questions that can be addressed. Just as you can improve carpentry with a hammer, a saw and a plane, team science can accomplish more than any one individual alone.\u201d<\/p>\n Clemens, who is also the Jaroslav Folda Distinguished Professor of Physics and Astronomy, works to provide innovation frameworks that will help guide teams of researchers through the process of translating basic research into innovations with commercial or social impact.<\/p>\n The innovative work of the Chemical Epigenomics Hub kicked off with a\u00a02019 award<\/a>\u00a0from the\u00a0Creativity Hubs award program<\/a>, which is managed by UNC-Chapel Hill\u2019s Office of the Vice Chancellor for Research. The Creativity Hubs are virtual research networks that convene research talent and resources into diverse, interdisciplinary faculty teams that pursue answers to complex problems.<\/p>\n Strahl\u2019s and Pattenden\u2019s epigenetic hub is also receiving support from the Institute for Convergent Science, which is operating in a pilot phase in the Genome Sciences Building through a partnership between the College of Arts & Sciences, UNC Research, Innovate Carolina and other campus units. ICS provides wet lab and startup accelerator space, funding, talent connections and other resources designed to help faculty take a problem-centered, team-based approach to research that launches new treatments, products and devices into the world.<\/p>\n \u201cTeam science is the best science. It allows us to do projects we never thought possible,\u201d says Pattenden. \u201cOur team offers a one-of-a-kind constellation of strengths in epigenetics, model organism research, computational biology, medicinal chemistry and drug discovery.\u201d<\/p>\n \u201cThe research we\u2019re doing could potentially lead to new patents and approaches, but also lead to new science and new ideas,\u201d says Strahl. \u201cFrom a conceptual standpoint, we\u2019re making new advances that could take us in directions we hadn\u2019t yet realized would be important.\u201d<\/p>\n With the work of the Chemical Epigenomics Hub, Strahl and Pattenden hope to eventually create a world-renowned Chemical Epigenomics Center at Carolina that offers a synergistic environment where University faculty can come together to tackle the most challenging foundational and translational problems in the field.<\/p>\n \u201cI\u2019m hoping we see results that can take us into a new area, which ultimately could secure new grants,\u201d says Strahl. \u201cOne of the main goals of the hub is that through our creativity and the work, we can standardize how we bring new grants to the table that weren\u2019t there previously or wouldn\u2019t have come otherwise.\u201d<\/p>\n Julia Flynn, lab assistant, works with stem cells in Strahl\u2019s lab. (Image courtesy of Innovate Carolina)<\/p>\n<\/div>\n The future center would address challenges in epigenetics, expand the range of new drug targets and discovery efforts, spur new innovation and intellectual property and aid in the creation of new chemical tools. Such goals are ambitious, and Pattenden sees the hub\u2019s collaborative approach to research and innovation as key to also making them attainable.<\/p>\n \u201cBeing at UNC has given me a new perspective on how to do science,\u201d says Pattenden. \u201cTeam science doesn\u2019t diminish an individual\u2019s contributions. The things I could do would be so small if I wasn\u2019t able to collaborate with people outside my own field.\u201d<\/p>\n\n![\"Brian](\"https:\/\/thewell.unc.edu\/wp-content\/uploads\/sites\/1007\/2021\/06\/brian-strahl-headshot-250x199.png\")
<\/p>\nTreating genetic diseases without changing the DNA<\/h2>\n
\n![\"](\"https:\/\/thewell.unc.edu\/wp-content\/uploads\/sites\/1007\/2021\/06\/pattenden-headshot-250x214.png\")
<\/p>\n\u2018Team science is the best science\u2019<\/h2>\n
\n![\"Briah](\"https:\/\/thewell.unc.edu\/wp-content\/uploads\/sites\/1007\/2021\/06\/0N2A2013-700x467.png\")
<\/p>\nA future epigenomics center<\/h2>\n
\n![\"A](\"https:\/\/thewell.unc.edu\/wp-content\/uploads\/sites\/1007\/2021\/06\/0N2A2020-700x467.png\")
<\/p>\nChemical Epigenomics Hub Team<\/h2>\n
Core Team<\/h3>\n
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Support Team<\/h3>\n
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