{"id":19848,"date":"2021-10-20T16:50:41","date_gmt":"2021-10-20T20:50:41","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=19848"},"modified":"2021-10-20T17:30:55","modified_gmt":"2021-10-20T21:30:55","slug":"powerful-technique-allows-unc-scientists-to-study-for-first-time-how-proteins-change-shape-inside-cells-onur-dagliyan-phd-2016-alum","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/powerful-technique-allows-unc-scientists-to-study-for-first-time-how-proteins-change-shape-inside-cells-onur-dagliyan-phd-2016-alum\/","title":{"rendered":"Powerful Technique Allows UNC Scientists to Study for First Time How Proteins Change Shape Inside Cells (Onur Dagliyan PhD, 2016 Alum)"},"content":{"rendered":"<article class=\"post-22542 post type-post status-publish format-standard has-post-thumbnail hentry category-news category-pharmacology category-research tag-press-releases tag-school-of-medicine odd\">\n<div class=\"entry-content\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-19853 size-full alignright\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/10\/rainbow-cell-image-with-purple-in-center.jpg\" alt=\"Klaus Hahn and Tim Elston rainbow cell image in Cell publication 2021\" width=\"359\" height=\"238\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/10\/rainbow-cell-image-with-purple-in-center.jpg 359w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/10\/rainbow-cell-image-with-purple-in-center-300x199.jpg 300w\" sizes=\"auto, (max-width: 359px) 100vw, 359px\" \/><\/p>\n<p>Understanding how proteins bend, twist, and shape-shift as they go about their work in cells is enormously important for understanding normal biology and diseases. But a deep understanding of protein dynamics has generally been elusive due to the lack of good imaging methods of proteins at work. Now, for the first time, scientists at the UNC School of Medicine have invented a method that could enable this field to take a great leap forward.<\/p>\n<p>The scientists\u2019 new \u201cbinder-tag\u201d technique, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0092867421011090\">described in a paper in <em>Cell<\/em><\/a>, allows researchers to pinpoint and track proteins that are in a desired shape or \u201cconformation,\u201d and to do so in real time inside living cells. The scientists demonstrated the technique in, essentially, movies that track the active version of an important signaling protein \u2013 a molecule, in this case, important for cell growth.<\/p>\n<p>\u201cNo one has been able to develop a method that can do, in such a generalizable way, what this method does. So I think it could have a very big impact,\u201d said study co-senior author<a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/klaus-m-hahn-phd\/\"> Klaus Hahn, PhD<\/a>, the Ronald G. Thurman Distinguished Professor of Pharmacology, and director of the UNC-Olympus Imaging Center, at UNC School of Medicine.<\/p>\n<p>The work was a collaboration between Hahn\u2019s laboratory and the laboratory of imaging analysis expert <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/timothy-elston\/\">Timothy Elston, PhD<\/a>, professor of pharmacology and co-director of the Computational Medicine Program at the UNC School of Medicine. Both are also members of the UNC Lineberger Comprehensive Cancer Center.<\/p>\n<p><strong><a href=\"https:\/\/news.unchealthcare.org\/2021\/10\/powerful-technique-allows-scientists-to-study-how-proteins-change-shape-inside-cells\/\">Continue reading on Vital Signs<\/a><\/strong><\/p>\n<hr \/>\n<figure id=\"attachment_11735\" class=\"thumbnail wp-caption alignright\" style=\"width: 160px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-11735 size-thumbnail\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/11\/Onur_Dagliyan_19-150x150.jpg\" alt=\"Onur Dagliyan PhD a 2016 program alumnus\" width=\"150\" height=\"150\" \/><figcaption class=\"caption wp-caption-text\"><em>Onur Dagliyan Ph.D., Research Fellow at Harvard Medical School (Class of 2016, BCBP and Hahn lab alumnus)<\/em><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<blockquote><p><em>The <\/em>Cell <em>paper, titled \u201c<strong>Biosensors based on peptide exposure show single-molecule conformations in live cells<\/strong>,\u201d was co-authored by Bei Liu, Orrin Stone, Michael Pablo, Cody Herron, Ana Nogueira, Onur Dagliyan, Jonathan Grimm, Luke Lavis, Timothy Elston, and Klaus Hahn.<\/em><\/p><\/blockquote>\n<\/div>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>This new method, created by the UNC School of Medicine labs of Klaus Hahn and Tim Elston, has the potential to super-charge the study of human proteins as they interact and change their conformations in fundamentally important ways in human health and disease. This research was a collaboration with many UNC departments and The Howard Hughes Medical Institute and was published in Cell!<\/p>\n","protected":false},"author":41619,"featured_media":19853,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[22,10,179],"class_list":["post-19848","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_alum","tag-news_faculty","tag-news_postdoc-scholars","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Powerful Technique Allows UNC Scientists to Study for First Time How Proteins Change Shape Inside Cells (Onur Dagliyan PhD, 2016 Alum) | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/powerful-technique-allows-unc-scientists-to-study-for-first-time-how-proteins-change-shape-inside-cells-onur-dagliyan-phd-2016-alum\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Powerful Technique Allows UNC Scientists to Study for First Time How Proteins Change Shape Inside Cells (Onur Dagliyan PhD, 2016 Alum) | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"This new method, created by the UNC School of Medicine labs of Klaus Hahn and Tim Elston, has the potential to super-charge the study of human proteins as they interact and change their conformations in fundamentally important ways in human health and disease. 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