{"id":21980,"date":"2022-04-04T15:00:15","date_gmt":"2022-04-04T19:00:15","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=21980"},"modified":"2022-04-04T15:00:15","modified_gmt":"2022-04-04T19:00:15","slug":"dr-robert-lee-bergmeier-lab-published-journal-of-clinical-investigation-insight","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/dr-robert-lee-bergmeier-lab-published-journal-of-clinical-investigation-insight\/","title":{"rendered":"Dr. Robert Lee, Bergmeier Lab Published: Journal of Clinical Investigation Insight"},"content":{"rendered":"<figure id=\"attachment_9789\" class=\"thumbnail wp-caption alignright\" style=\"width: 224px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9789\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2015\/06\/Bobby-H.-Lee-Postdoc-2019-Bergmeier-lab-214x300.jpg\" alt=\"Bobby H. Lee\" width=\"214\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2015\/06\/Bobby-H.-Lee-Postdoc-2019-Bergmeier-lab-214x300.jpg 214w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2015\/06\/Bobby-H.-Lee-Postdoc-2019-Bergmeier-lab.jpg 285w\" sizes=\"auto, (max-width: 214px) 100vw, 214px\" \/><figcaption class=\"caption wp-caption-text\">Robert H. Lee, Ph.D., Research Assistant Professor<\/figcaption><\/figure>\n<blockquote><p>Platelet homeostasis, i.e. a stable platelet count in the circulation, is dependent on a tight regulation of both platelet production and clearance. Dr. Robert Lee, in collaboration with members of the Bergmeier lab, the Flick lab, and international collaborators, recently published their studies on the effect of uninhibited signaling by the small GTPase Rap1 on platelet homeostasis. Their findings, published in the\u00a0<em>Journal of Clinical Investigation Insight<\/em>, describe a novel, integrin-based mechanism of platelet clearance that could be critical for our understanding of select inherited and acquired thrombocytopenias.<\/p>\n<p>&nbsp;<\/p><\/blockquote>\n<p>Click here to read <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35290242\/\">the published study, &#8220;Rasa3 deficiency minimally impacts thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance.&#8221;<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Robert Lee, in collaboration with members of the Bergmeier lab, the Flick lab, and international collaborators, recently published their studies on the effect of uninhibited signaling by the small GTPase Rap1 on platelet homeostasis.<\/p>\n","protected":false},"author":41619,"featured_media":9789,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,378],"class_list":["post-21980","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2022","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dr. Robert Lee, Bergmeier Lab Published: Journal of Clinical Investigation Insight | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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