{"id":22113,"date":"2022-04-25T06:11:52","date_gmt":"2022-04-25T10:11:52","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=22113"},"modified":"2022-04-25T09:00:30","modified_gmt":"2022-04-25T13:00:30","slug":"ramos-lab-publishes-rna-research-in-nucleic-acids-research","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/ramos-lab-publishes-rna-research-in-nucleic-acids-research\/","title":{"rendered":"Ramos lab publishes RNA research in Nucleic Acids Research"},"content":{"rendered":"<h2>Research highlight<\/h2>\n<figure id=\"attachment_16585\" class=\"thumbnail wp-caption alignright\" style=\"width: 160px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-16585 size-thumbnail\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/ramos_silvia_2017-150x150.jpeg\" alt=\"Silvia Ramos\" width=\"150\" height=\"150\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/ramos_silvia_2017-150x150.jpeg 150w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/ramos_silvia_2017-600x600.jpeg 600w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><figcaption class=\"caption wp-caption-text\">Silvia B. Ramos, MD\/PhD, Associate professor<\/figcaption><\/figure>\n<p><span class=\"mark1epieg30v LMEtDboTwopWdh5S5P1E\" data-markjs=\"true\">Congratulations<\/span>\u00a0to <a href=\"https:\/\/www.med.unc.edu\/biochem\/directory\/ramos\/\">Ramos lab<\/a> and UNC collaborators for their recent publication in Nucleic Acids Research describing the discovery of a novel mRNA target, Elavl2, for the RNA binding protein, ZFP36L2. Collectively, the results of these researchers propose a model in which the balance between two RNA-binding proteins with opposing effects, ZFP36L2 which degrades mRNA, and ELAVL2 which stabilizes mRNA, controls gene expression of a subset of transcripts. Notably, they demonstrate that ZFP36L2 binds and degrades Elavl2 mRNA. When ZFP36L2 is absent, such as in their knockout mice, the ELAVL2 protein effect predominates and stabilizes its own mRNA in the spleen.<\/p>\n<figure id=\"attachment_22170\" class=\"thumbnail wp-caption alignnone\" style=\"width: 310px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-22170\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/04\/3-trainees-fro-Ramos-lab-300x96.png\" alt=\"First-co-authors Ian C. Redmon and Matthew Ardizzone, undergraduate researchers; Hilal Hekimo\u011flu, International visiting master\u2019s student in Ramos lab\" width=\"300\" height=\"96\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/04\/3-trainees-fro-Ramos-lab-300x96.png 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/04\/3-trainees-fro-Ramos-lab.png 512w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"caption wp-caption-text\">Ian C. Redmon and Matthew Ardizzone, undergrad researchers; Hilal Hekimo\u011flu, International visiting master\u2019s student<\/figcaption><\/figure>\n<blockquote><p>&#8220;Congratulations to first-co-authors Ian C. Redmon and Matthew Ardizzone, undergraduate researchers in the Biochemistry and Biophysics department, and Hilal Hekimo\u011flu, an International visiting master\u2019s student from Turkey and to all other authors!&#8221;<\/p><\/blockquote>\n<h2>Link to publication in NAR<\/h2>\n<p>Ian C Redmon, Matthew Ardizzone, Hilal Hekimo\u011flu, Breanne M Hatfield, Justin\u00a0M Waldern, Abhishek Dey, Stephanie A Montgomery, Alain Laederach, Silvia B V Ramos, <a href=\"https:\/\/doi.org\/10.1093\/nar\/gkac209\">Sequence and tissue targeting specificity of ZFP36L2 reveals\u00a0<em>Elavl2<\/em>\u00a0as a novel target with co-regulation potential,\u00a0<em>Nucleic Acids Research<\/em><\/a>, Volume 50, Issue 7, 22 April 2022, Pages 4068\u20134082.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Congratulations to Ramos lab and UNC collaborators for their recent publication in Nucleic Acids Research describing the discovery of a novel mRNA target, Elavl2, for the RNA binding protein, ZFP36L2. Congratulations to first-co-authors Ian C. Redmon and Matthew Ardizzone, undergraduate researchers in the Biochemistry and Biophysics department, and Hilal Hekimo\u011flu, an International visiting master\u2019s student and to all authors! <\/p>\n","protected":false},"author":41619,"featured_media":16585,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,378,13],"class_list":["post-22113","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2022","tag-news_students","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ramos lab publishes RNA research in Nucleic Acids Research | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/ramos-lab-publishes-rna-research-in-nucleic-acids-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ramos lab publishes RNA research in Nucleic Acids Research | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Congratulations to Ramos lab and UNC collaborators for their recent publication in Nucleic Acids Research describing the discovery of a novel mRNA target, Elavl2, for the RNA binding protein, ZFP36L2. Congratulations to first-co-authors Ian C. Redmon and Matthew Ardizzone, undergraduate researchers in the Biochemistry and Biophysics department, and Hilal Hekimo\u011flu, an International visiting master\u2019s student and to all authors!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/ramos-lab-publishes-rna-research-in-nucleic-acids-research\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-25T10:11:52+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-04-25T13:00:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/ramos_silvia_2017.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"2100\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/ramos-lab-publishes-rna-research-in-nucleic-acids-research\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/ramos-lab-publishes-rna-research-in-nucleic-acids-research\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"Ramos lab publishes RNA research in Nucleic Acids Research\",\"datePublished\":\"2022-04-25T10:11:52+00:00\",\"dateModified\":\"2022-04-25T13:00:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/ramos-lab-publishes-rna-research-in-nucleic-acids-research\/\"},\"wordCount\":240,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/ramos-lab-publishes-rna-research-in-nucleic-acids-research\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/01\/ramos_silvia_2017.jpeg\",\"keywords\":[\"Faculty &amp; 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