{"id":22783,"date":"2022-06-17T14:25:49","date_gmt":"2022-06-17T18:25:49","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=22783"},"modified":"2022-06-17T14:30:44","modified_gmt":"2022-06-17T18:30:44","slug":"viet-vu-rosetta-reu-intern-joins-the-kuhlman-lab","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/viet-vu-rosetta-reu-intern-joins-the-kuhlman-lab\/","title":{"rendered":"Viet Vu, Rosetta REU intern, joins the Kuhlman Lab!"},"content":{"rendered":"<div><a href=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/REU-experience-at-UNC-summer-of-2022-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-22786 size-large\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/REU-experience-at-UNC-summer-of-2022-1024x557.jpg\" alt=\"REU  group jumping into the air at UNC summer 2022\" width=\"1024\" height=\"557\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/REU-experience-at-UNC-summer-of-2022-1024x557.jpg 1024w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/REU-experience-at-UNC-summer-of-2022-300x163.jpg 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/REU-experience-at-UNC-summer-of-2022-768x418.jpg 768w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/REU-experience-at-UNC-summer-of-2022-1536x836.jpg 1536w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/REU-experience-at-UNC-summer-of-2022-2048x1115.jpg 2048w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/REU-experience-at-UNC-summer-of-2022-600x327.jpg 600w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/REU-experience-at-UNC-summer-of-2022-560x305.jpg 560w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/div>\n<div>\n<hr \/>\n<figure id=\"attachment_22785\" class=\"thumbnail wp-caption alignright\" style=\"width: 279px\"><a href=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/Viet-Vu-and-Nick-Randolph-in-Kuhlman-lab.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-22785 size-medium\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/Viet-Vu-and-Nick-Randolph-in-Kuhlman-lab-269x300.png\" alt=\"Viet Vu and Nick Randolph in Kuhlman lab\" width=\"269\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/Viet-Vu-and-Nick-Randolph-in-Kuhlman-lab-269x300.png 269w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2022\/06\/Viet-Vu-and-Nick-Randolph-in-Kuhlman-lab.png 535w\" sizes=\"auto, (max-width: 269px) 100vw, 269px\" \/><\/a><figcaption class=\"caption wp-caption-text\">Viet Vu and Nick Randolph in Kuhlman lab<\/figcaption><\/figure>\n<p>Viet Vu is a rising senior undergraduate\u00a0student at Harvard University studying Computational Biology and is currently participating in this summer&#8217;s Rosetta Commons Research Experience for Undergraduates program, which is supported by the National Science Foundation.<\/p><\/div>\n<div><\/div>\n<div>Viet will work alongside\u00a0Nick Randolph, a rising third\u00a0year graduate student in the Kuhlman lab and an\u00a0NSF Graduate Research Fellow, who has a background in Applied Mathematics and Chemical Engineering.<\/div>\n<div><\/div>\n<div>This summer Viet and Nick will work together over 8 weeks to create a\u00a0deep learning-based model that predicts metal binding sites.\u00a0Metal binding sites are common within proteins, with roughly a third of all protein structures in the Protein Data Bank containing a metal ion. These sites are crucial for a variety of functions, including notably catalysis and transition state stabilization. While traditional physics-based methods have had some success in the design of metal binding sites, design of these sites is often time-consuming. Nick and Viet aim to develop a deep learning-based model that, given a protein scaffold, will identify sets of residues that can be mutated to create a favorable metal binding site.<\/div>\n<div><\/div>\n<p>Additionally, as a Rosetta REU intern, Viet spent one week in a Rosetta Code School that covered topics such as\u00a0PyRosetta and community coding prior to joining the Kuhlman Lab to conduct research.\u00a0To end the summer internship, Viet and other Kuhlman Lab members will travel to Seattle and\u00a0Leavenworth, Washington to present their work at the annual RosettaCON conference held from August 9<sup>th<\/sup>\u00a0to 12<sup>th<\/sup>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Viet Vu is a rising senior undergrad at Harvard University studying Computational Biology and is currently participating in this summer&#8217;s Rosetta Commons Research Experience for Undergraduates program, which is supported by the National Science Foundation.<\/p>\n","protected":false},"author":41619,"featured_media":22785,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[378,13],"class_list":["post-22783","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_2022","tag-news_students","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Viet Vu, Rosetta REU intern, joins the Kuhlman Lab! 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