{"id":24415,"date":"2022-11-09T13:12:15","date_gmt":"2022-11-09T18:12:15","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=24415"},"modified":"2022-12-08T13:32:13","modified_gmt":"2022-12-08T18:32:13","slug":"postdoc-jun-wang-first-co-author-publishes-in-nature-genetics-histone-h3-proline-16-hydroxylation-regulates-mammalian-gene-expression","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/postdoc-jun-wang-first-co-author-publishes-in-nature-genetics-histone-h3-proline-16-hydroxylation-regulates-mammalian-gene-expression\/","title":{"rendered":"postdoc Jun Wang first co-author publishes in Nature Genetics “Histone H3 proline 16 hydroxylation regulates mammalian gene expression”"},"content":{"rendered":"

This publication is the result of collaboration with many researchers from UNC biochemistry and biophysics, Lineberger, University of Texas Southwestern, University of Edinburgh, Center for Epigenetics-Van Andel Institute, and Yale. First co-authors are Drs. Xijuan Liu and Jun Wang. Congratulations on your publication in Nature! Subjects: Breast cancer, Epigenetics, Gene Expression.<\/p>\n

\n

Abstract<\/h2>\n

Histone post-translational modifications (PTMs) are important for regulating various DNA-templated processes. Here, we report the existence of a histone PTM in mammalian cells, namely histone H3 with hydroxylation of proline at residue 16 (H3P16oh), which is catalyzed by the proline hydroxylase EGLN2. We show that H3P16oh enhances direct binding of KDM5A to its substrate, histone H3 with trimethylation at the fourth lysine residue (H3K4me3), resulting in enhanced chromatin recruitment of KDM5A and a corresponding decrease of H3K4me3 at target genes. Genome- and transcriptome-wide analyses show that the EGLN2\u2013KDM5A axis regulates target gene expression in mammalian cells. Specifically, our data demonstrate repression of the WNT pathway negative regulator DKK1 through the EGLN2-H3P16oh-KDM5A pathway to promote WNT\/\u03b2-catenin signaling in triple-negative breast cancer (TNBC). This study characterizes a regulatory mark in the histone code and reveals a role for H3P16oh in regulating mammalian gene expression.<\/p>\n

Publication<\/h2>\n

Liu, X., Wang, J., Boyer, J.A. et al. Histone H3 proline 16 hydroxylation regulates mammalian gene expression.<\/a> Nat Genet 54, 1721\u20131735 (2022). https:\/\/doi.org\/10.1038\/s41588-022-01212-x<\/p>\n

All authors:
\nXijuan Liu, Jun Wang, Joshua A. Boyer, Weida Gong, Shuai Zhao, Ling Xie, Qiong Wu, Cheng Zhang, Kanishk Jain, Yiran Guo, Javier Rodriguez, Mingjie Li, Hidetaka Uryu, Chengheng Liao, Lianxin Hu, Jin Zhou, Xiaobing Shi, Yi-Hsuan Tsai, Qin Yan, Weibo Luo, Xian Chen, Brian D. Strahl, Alex von Kriegsheim, Qi Zhang, Gang Greg Wang, Albert S. Baldwin & Qing Zhang<\/p>\n","protected":false},"excerpt":{"rendered":"

This publication is the result of collaboration with many researchers from UNC Biochemistry and Biophysics, Lineberger, University of Texas Southwestern, University of Edinburgh, Center for Epigenetics-Van Andel Institute, and Yale. First co-authors are Drs. Xijuan Liu and Jun Wang. Congratulations on your publication in Nature! Subjects: Breast cancer, Epigenetics, Gene Expression.<\/p>\n","protected":false},"author":41619,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,378,179],"class_list":["post-24415","post","type-post","status-publish","format-standard","hentry","category-news","tag-news_faculty","tag-news_2022","tag-news_postdoc-scholars","odd"],"acf":[],"yoast_head":"\npostdoc Jun Wang first co-author publishes in Nature Genetics "Histone H3 proline 16 hydroxylation regulates mammalian gene expression" | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/postdoc-jun-wang-first-co-author-publishes-in-nature-genetics-histone-h3-proline-16-hydroxylation-regulates-mammalian-gene-expression\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"postdoc Jun Wang first co-author publishes in Nature Genetics "Histone H3 proline 16 hydroxylation regulates mammalian gene expression" | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"This publication is the result of collaboration with many researchers from UNC Biochemistry and Biophysics, Lineberger, University of Texas Southwestern, University of Edinburgh, Center for Epigenetics-Van Andel Institute, and Yale. 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