{"id":24997,"date":"2023-01-25T11:50:25","date_gmt":"2023-01-25T16:50:25","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=24997"},"modified":"2023-01-27T14:34:44","modified_gmt":"2023-01-27T19:34:44","slug":"spotlight-on-research-in-jill-dowens-lab","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/spotlight-on-research-in-jill-dowens-lab\/","title":{"rendered":"Spotlight on research in Jill Dowen’s lab"},"content":{"rendered":"

Please view the YouTube video<\/strong> project produced and written by Gabrielle Dardis, a PhD Student in the Baldwin lab\u00a0at this link Dowen Lab Profile.<\/a><\/strong><\/em><\/p>\n

\n
\"Jill
Jill Dowen PhD and Riya Gohil, graduate student<\/figcaption><\/figure>\n

Spotlight on research in Jill Dowen\u2019s lab<\/strong><\/p>\n

Dr. Jill Dowen\u2019s <\/span>lab<\/span><\/a> in the <\/span>Department of Biochemistry and Biophysics<\/span><\/a> at UNC Chapel Hill studies the spatial organization of the genome, and how this affects gene expression in both healthy and disease states. Dowen, who grew up in Iowa and attended the University of Iowa, started her research lab at UNC in 2016 following her graduate work at the University of California San Diego and postdoctoral fellowship at MIT, and was <\/span>recently promoted<\/a><\/span> to associate professor with tenure.<\/span>\u00a0<\/span><\/p>\n

The Dowen lab<\/a> is <\/span>interested<\/span> in uncovering how DNA is compacted, organized, and regulated to allow for cells to function \u2013 and how this process can go wrong and lead to disease. Using a variety of cutting-edge approaches like CRISPR-Cas9 genome engineering and spatial genomics <\/a><\/span>techniques<\/span>, students address different facets of this big-picture question in their own independent projects.<\/span>\u00a0<\/span><\/p>\n

\u201cI think what fascinates me the most is that if you take DNA from a single cell and stretch it out, it is six feet tall – and that needs to fit inside the nucleus of a cell,\u201d says third-year student Riya Gohil. In her graduate work, she is developing new cell lines to study various proteins and how they govern DNA compaction and genome structure.\u00a0<\/em><\/span><\/p>\n

\"Natalie
Graduate student Natalie Rittenhouse<\/figcaption><\/figure>\n

In addition to understanding healthy biological processes, the lab harbors an interest in dysfunctional events in genome organization. Natalie Rittenhouse, a fourth-year student, is focused on an important DNA compaction protein called <\/span>cohesin<\/span><\/a>, and aims to identify novel interacting partners that might contribute to disease states.<\/span><\/p>\n

In fact, Dowen <\/span>considers<\/span> the b<\/span>iggest<\/span> downstream<\/span> impact <\/span>of <\/span>the lab\u2019s research <\/span>to be <\/span>defin<\/span>ing<\/span> the <\/span>earliest molecular defects that happen in the disease process<\/span>: <\/span>\u201c<\/span>W<\/span>e <\/span>don\u2019t<\/span> yet understand the earliest molecular or cellular problems that are the tip of the iceberg that leads to all the downstream disease pathologies<\/span>, so w<\/span>e hope to make important contributions in this earliest step of understanding human disease<\/span>.\u201d<\/span><\/span>\u00a0<\/span><\/p>\n

\"Riya
Graduate students Riya Gohil and Geoffrey Fox<\/figcaption><\/figure>\n

S<\/span>econd-year student Geoffrey Fox is particularly interested in understanding the molecular mechanisms underlying gene regulation that go wrong in diseas<\/span>e, and<\/span> ultimately<\/span> believes<\/span>, \u201c<\/span>the biggest impact that could come of that is better informing therapeutic development and the development of preventative measures for disease<\/span>.”<\/span><\/p>\n

When reflecting on why they chose to attend UNC, Gohil, Rittenhouse, and Fox echoed their partiality for the collaborative environment. Beyond an excellent cast of Principal Investigators conducting world-class research, the supportive community at UNC and in the Biochemistry and Biophysics Department was cited as both a draw and a continued benefit by all three students. Further, Dowen says her proudest moments are seeing the people in her lab grow and succeed both during and after their graduate training. <\/span>\u00a0<\/span><\/p>\n

The Dowen Lab is currently accepting <\/span>applications<\/span><\/a> for interested graduate students, and the Biochemistry and Biophysics Department additionally houses an excellent <\/span>cohort of labs<\/span><\/a> specializing in genetics and molecular biology.<\/span>\u00a0<\/span><\/p>\n

Author: Gabrielle J. Dardis, a PhD Student in the Baldwin lab.<\/em><\/p>\n

\n
\"Profile
YouTube video project completed by Gabrielle Dardis\u00a0at this link Dowen Lab Profile.<\/figcaption><\/figure>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Please view the YouTube video project produced and written by Gabrielle Dardis, a PhD Student in the Baldwin lab\u00a0at this link Dowen Lab Profile. Spotlight on research in Jill Dowen\u2019s lab Dr. Jill Dowen\u2019s lab in the Department of Biochemistry and Biophysics at UNC Chapel Hill studies the spatial organization of the genome, and how … Read more<\/a><\/p>\n","protected":false},"author":41619,"featured_media":25022,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,385,13],"class_list":["post-24997","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2023","tag-news_students","odd"],"acf":[],"yoast_head":"\nSpotlight on research in Jill Dowen's lab | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/spotlight-on-research-in-jill-dowens-lab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Spotlight on research in Jill Dowen's lab | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Please view the YouTube video project produced and written by Gabrielle Dardis, a PhD Student in the Baldwin lab\u00a0at this link Dowen Lab Profile. 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