{"id":26008,"date":"2023-04-10T08:36:53","date_gmt":"2023-04-10T12:36:53","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=26008"},"modified":"2025-01-24T15:59:41","modified_gmt":"2025-01-24T20:59:41","slug":"congrats-to-graduate-student-quentin-hahn-on-his-publication-in-nature","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/congrats-to-graduate-student-quentin-hahn-on-his-publication-in-nature\/","title":{"rendered":"Congrats to graduate student Quentin Hahn on his publication in Nature"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-26021 alignright\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2023\/04\/test-from-NAture-photo-image-1-2023-300x279.jpg\" alt=\"image from Nature 1-2023\" width=\"300\" height=\"279\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2023\/04\/test-from-NAture-photo-image-1-2023-300x279.jpg 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2023\/04\/test-from-NAture-photo-image-1-2023-600x558.jpg 600w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2023\/04\/test-from-NAture-photo-image-1-2023-560x520.jpg 560w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2023\/04\/test-from-NAture-photo-image-1-2023.jpg 680w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><strong>\u00a0\u00a0<\/strong><\/p>\n<hr \/>\n<p>This publication was for a research project that he was working on at Boston Children\u2019s Hospital before coming to UNC. Quentin was a Research Assistant under Dr. Richard Gregory of Harvard Medical School in the department of pediatric oncology, working in a lab focused on understanding molecular and cellular mechanisms controlling RNA biogenesis and decay, and exploring the relevance of these pathways in stem cell pluripotency, mammalian development, and human disease.<br \/>\nTheir work involved the ternary structural analysis of an RNA methyltransferase which is responsible for the 46- N7-methylguanosine (m7G46) modification on the tRNA variable loop. The gene is frequently amplified and overexpressed in cancers and is shown to correlate with poor patient survival, making it a key target for therapeutic research. We have shown that an abundance of m7G-modified tRNA, alters cell cycle, and is directly linked to oncogenicity and tumorigenesis.<\/p>\n<figure id=\"attachment_26009\" class=\"thumbnail wp-caption alignleft\" style=\"width: 160px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-26009 size-thumbnail\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2023\/04\/Quentin-Hahn-150x150.jpg\" alt=\"Quentin Hahn\" width=\"150\" height=\"150\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2023\/04\/Quentin-Hahn-150x150.jpg 150w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2023\/04\/Quentin-Hahn-300x300.jpg 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2023\/04\/Quentin-Hahn-600x600.jpg 600w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2023\/04\/Quentin-Hahn-560x560.jpg 560w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2023\/04\/Quentin-Hahn.jpg 657w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><figcaption class=\"caption wp-caption-text\">Quentin Hahn<\/figcaption><\/figure>\n<blockquote><p>Li, J., Wang, L., Hahn, Q. <em>et al.<\/em> <a href=\"https:\/\/doi.org\/10.1038\/s41586-022-05566-4\">Structural basis of regulated m7G tRNA modification by METTL1\u2013WDR4.<\/a> <em>Nature<\/em> 613, 391\u2013397 (2023).<\/p>\n<p>Excellent work Quentin! He will be joining the labs of Qi Zhang and Pengda Liu in the Spring of 2023.<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>This publication was for a research project that he was working on at Boston Children\u2019s Hospital before coming to UNC.<\/p>\n","protected":false},"author":41619,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[385,13],"class_list":["post-26008","post","type-post","status-publish","format-standard","hentry","category-news","tag-news_2023","tag-news_students","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Congrats to graduate student Quentin Hahn on his publication in Nature | Biochemistry and 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