{"id":28268,"date":"2024-01-10T15:29:15","date_gmt":"2024-01-10T20:29:15","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=28268"},"modified":"2024-02-06T16:50:13","modified_gmt":"2024-02-06T21:50:13","slug":"breaking-boundaries-a-journey-into-directional-catch-bonds-reveals-cellular-secrets","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/breaking-boundaries-a-journey-into-directional-catch-bonds-reveals-cellular-secrets\/","title":{"rendered":"Breaking Boundaries: A Journey into Directional Catch Bonds Reveals Cellular Secrets"},"content":{"rendered":"<p>In a groundbreaking study from our department, researchers explored into the intricate world of mechanical responses within mammalian cells and tissues. The team, led by <a href=\"https:\/\/www.med.unc.edu\/biochem\/directory\/campbell\/\">Dr. Sharon L Campbell<\/a>, in collaboration with Dr. Brenton D. Hoffman lab at the Duke University focused on understanding how load-bearing proteins can dynamically resist or accommodate mechanical forces in different directions. Specifically, their work centered on elucidating the phenomenon of directional catch bonds between F-actin and vinculin (Vcn) in cell-ECM adhesion. Employing an innovative approach that integrated Molecular Dynamics Simulations, rational engineering, biochemical validation, and FRET-based biosensor studies, the researchers successfully identified and characterized amino acid variants mediating directional catch bonding. The results, published in Nature Communications, shed light on the nuanced role of Vcn in influencing cell substructures and overall cellular behavior, with minimal impact on other cellular functions. This interdisciplinary investigation not only advances our understanding of the molecular mechanisms behind directional catch bonding but also holds promise for applications in cell\u2013ECM adhesion, single-cell migration, and potentially in broader cellular processes such as cell\u2013cell adhesion and collective migration in both developmental and pathophysiological contexts.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-28269 size-full\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/01\/campbell-lab-image-1-2024.png\" alt=\"campbell lab image 1-2024\" width=\"608\" height=\"424\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/01\/campbell-lab-image-1-2024.png 608w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/01\/campbell-lab-image-1-2024-300x209.png 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/01\/campbell-lab-image-1-2024-600x418.png 600w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/01\/campbell-lab-image-1-2024-560x391.png 560w\" sizes=\"auto, (max-width: 608px) 100vw, 608px\" \/><\/p>\n<p>Evaluation of energetics and hydrogen bond properties between F-actin and Vt<\/p>\n<p>Link to publication:<\/p>\n<p>Chirasani, V.R., Khan, M.A.I., Malavade, J.N.\u00a0<i>et al.<\/i>\u00a0<a href=\"https:\/\/rdcu.be\/dvFZa\">Molecular basis and cellular functions of vinculin-actin directional catch bonding<\/a>.\u00a0<i>Nat Commun<\/i>\u00a0<b>14<\/b>, 8300 (2023).<\/p>\n<hr \/>\n<p>Tags: \u00a0<a href=\"https:\/\/campbelllab.weebly.com\/\"><span class=\"markyoewn697o\" data-markjs=\"true\" data-ogac=\"\" data-ogab=\"\" data-ogsc=\"\" data-ogsb=\"\">Campbell<\/span>\u00a0<span class=\"markw70pt3isp\" data-markjs=\"true\" data-ogac=\"\" data-ogab=\"\" data-ogsc=\"\" data-ogsb=\"\">lab<\/span><\/a> and the <a href=\"https:\/\/www.med.unc.edu\/csb\/sbi\/\">R.L. Juliano Structural Bioinformatics Core<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Sharon L Campbell, in collaboration with Dr. Brenton D. Hoffman lab at the Duke University uncovers the molecular secrets behind directional force-sensitive binding of the cell adhesion protein vinculin (key player in cellular responses to mechanical forces) with filamentous actin. Special thanks to the R.L. Juliano Structural Bioinformatics Core.<\/p>\n","protected":false},"author":41619,"featured_media":28269,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,394],"class_list":["post-28268","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2024","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Breaking Boundaries: A Journey into Directional Catch Bonds Reveals Cellular Secrets | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/breaking-boundaries-a-journey-into-directional-catch-bonds-reveals-cellular-secrets\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Breaking Boundaries: A Journey into Directional Catch Bonds Reveals Cellular Secrets | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Dr. Sharon L Campbell, in collaboration with Dr. Brenton D. Hoffman lab at the Duke University uncovers the molecular secrets behind directional force-sensitive binding of the cell adhesion protein vinculin (key player in cellular responses to mechanical forces) with filamentous actin. Special thanks to the R.L. Juliano Structural Bioinformatics Core.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/breaking-boundaries-a-journey-into-directional-catch-bonds-reveals-cellular-secrets\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-10T20:29:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-06T21:50:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/01\/campbell-lab-image-1-2024.png\" \/>\n\t<meta property=\"og:image:width\" content=\"608\" \/>\n\t<meta property=\"og:image:height\" content=\"424\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/breaking-boundaries-a-journey-into-directional-catch-bonds-reveals-cellular-secrets\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/breaking-boundaries-a-journey-into-directional-catch-bonds-reveals-cellular-secrets\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"Breaking Boundaries: A Journey into Directional Catch Bonds Reveals Cellular Secrets\",\"datePublished\":\"2024-01-10T20:29:15+00:00\",\"dateModified\":\"2024-02-06T21:50:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/breaking-boundaries-a-journey-into-directional-catch-bonds-reveals-cellular-secrets\/\"},\"wordCount\":244,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/breaking-boundaries-a-journey-into-directional-catch-bonds-reveals-cellular-secrets\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/01\/campbell-lab-image-1-2024.png\",\"keywords\":[\"Faculty &amp; 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