{"id":29673,"date":"2024-09-13T15:32:44","date_gmt":"2024-09-13T19:32:44","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=29673"},"modified":"2024-09-13T15:34:04","modified_gmt":"2024-09-13T19:34:04","slug":"liu-lab-spotlight-recent-publications-and-new-grant","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/liu-lab-spotlight-recent-publications-and-new-grant\/","title":{"rendered":"Liu Lab spotlight: recent publications and new grant"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-29674 alignleft\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/09\/Liu-lab-member-photo-best-one-2024submission-247x300.png\" alt=\"Pengda Liu and his lab sitting around a dinner table celebrating after a lab meeting in 2024\" width=\"247\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/09\/Liu-lab-member-photo-best-one-2024submission-247x300.png 247w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/09\/Liu-lab-member-photo-best-one-2024submission-600x729.png 600w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/09\/Liu-lab-member-photo-best-one-2024submission-560x681.png 560w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/09\/Liu-lab-member-photo-best-one-2024submission.png 604w\" sizes=\"auto, (max-width: 247px) 100vw, 247px\" \/><span class=\"TextRun SCXW132390299 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW132390299 BCX8\">The Liu lab consists of a group of young scientists with <\/span><span class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW132390299 BCX8\">passion<\/span><span class=\"NormalTextRun SCXW132390299 BCX8\"> for biomedical research. The goal of Liu lab is to better understand deregulated signaling events in cancer to search for new drug targets and develop new treatment modalities. One focus of the Liu lab is on the ubiquitin\/kinase signaling to define cancer type specific drivers. The other focus is to understand roles of the innate immune <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW132390299 BCX8\">cGAS<\/span><span class=\"NormalTextRun SCXW132390299 BCX8\">\/STING signaling in cancer and other human diseases. We do both basic and preclinical science to develop new knowledge and help patients. We collaborate with the great UNC community and beyond to actively find cures for cancer and related human disorders.<\/span><\/span><span class=\"EOP SCXW132390299 BCX8\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_20162\" class=\"thumbnail wp-caption alignright\" style=\"width: 223px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20162\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2021\/11\/Pengda-Liu-PhD-2021-235x300.png\" alt=\"Pengda Liu PhD\" width=\"213\" height=\"272\" \/><figcaption class=\"caption wp-caption-text\">Pengda Liu PhD, Yang Family Biomedical Scholar and Associate Professor<\/figcaption><\/figure>\n<p>Congratulations to the Liu lab who recently had two papers published and a new grant!<\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;134225954&quot;:true,&quot;134225961&quot;:true,&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39228373\/\"><span data-contrast=\"none\">Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency.<\/span><\/a><span data-contrast=\"none\">\u00a0<\/span> <span data-contrast=\"none\">Chen J, Su S, Pickar-Oliver A, Chiarella AM, Hahn Q, Goldfarb D, Cloer EW, Small GW, Sivashankar S, Ramsden DA, Major MB, Hathaway NA, Gersbach CA,\u00a0<\/span><b><span data-contrast=\"none\">Liu P.<\/span><\/b><span data-contrast=\"none\">\u00a0Nucleic Acids Res. 2024 Sep 4:gkae761. doi: 10.1093\/nar\/gkae761. Online ahead of print. PMID: 39228373 &#8211; <\/span><i><span data-contrast=\"none\">This study is of interest to anyone who has been and is going to use CRISPR-mediated gene editing and epigenome editing.<\/span><\/i><span data-contrast=\"none\">\u00a0This is a collaboration among UNC\/Duke labs.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;134225954&quot;:true,&quot;134225961&quot;:true,&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38906855\/\"><span data-contrast=\"none\">Co-targeting JAK1\/STAT6\/GAS6\/TAM signaling improves chemotherapy efficacy in Ewing sarcoma.<\/span><\/a><span data-contrast=\"none\"> Yu L, Deng Y, Wang X, Santos C, Davis IJ, Earp HS,\u00a0<\/span><b><span data-contrast=\"none\">Liu P.<\/span><\/b><span data-contrast=\"none\">\u00a0Nat Commun. 2024 Jun 21;15(1):5292. doi: 10.1038\/s41467-024-49667-2. PMID: 38906855 Free PMC article.\u00a0Another study came to a similar conclusion: <\/span><a href=\"https:\/\/www.mdpi.com\/2072-6694\/16\/16\/2831\"><span data-contrast=\"none\">https:\/\/www.mdpi.com\/2072-6694\/16\/16\/2831<\/span><\/a><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;134225954&quot;:true,&quot;134225961&quot;:true,&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">Grant news: Liu lab received <\/span><span data-contrast=\"none\">a foundation grant from the Mary Kay Ash foundation<\/span><span data-contrast=\"none\"> for the project entitled &#8220;Statins suppress breast cancer metastasis by controlling canonical and non-canonical 2\u20193\u2019-cGAMP signaling.&#8221;\u00a0Grant amount: $100,000. Grant period: July 1st, 2024-June 30, 2026. <\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/unclineberger.org\/pengdaliulab\/lab-members\/\">Pengda Liu lab website<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Liu lab consists of a group of young scientists with passion for biomedical research. The goal of Liu lab is to better understand deregulated signaling events in cancer to search for new drug targets and develop new treatment modalities. One focus of the Liu lab is on the ubiquitin\/kinase signaling to define cancer type &hellip; <a href=\"https:\/\/www.med.unc.edu\/biochem\/news\/liu-lab-spotlight-recent-publications-and-new-grant\/\" aria-label=\"Read more about Liu Lab spotlight: recent publications and new grant\">Read more<\/a><\/p>\n","protected":false},"author":41619,"featured_media":29674,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,394],"class_list":["post-29673","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2024","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Liu Lab spotlight: recent publications and new grant | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/liu-lab-spotlight-recent-publications-and-new-grant\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Liu Lab spotlight: recent publications and new grant | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"The Liu lab consists of a group of young scientists with passion for biomedical research. 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