{"id":29824,"date":"2024-10-09T13:55:26","date_gmt":"2024-10-09T17:55:26","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=29824"},"modified":"2024-10-10T14:19:26","modified_gmt":"2024-10-10T18:19:26","slug":"2024-nobel-prize-in-chemistry-honors-work-linked-to-unc-scientist-dr-brian-kuhlman","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/2024-nobel-prize-in-chemistry-honors-work-linked-to-unc-scientist-dr-brian-kuhlman\/","title":{"rendered":"2024 Nobel Prize in Chemistry Honors Work Linked to UNC Scientist: Dr. Brian Kuhlman"},"content":{"rendered":"
\n

On October 9, 2024, the Royal Swedish Academy of Sciences announced that the 2024 Nobel Prize in Chemistry has been awarded to David Baker (1\/2) and to Demis Hassabis and John M. Jumper (1\/2) for their groundbreaking work in computational protein design and protein structure prediction.<\/p>\n<\/div>\n

\n

This prestigious recognition highlights the significant contributions of Dr. Brian Kuhlman, a current faculty member at UNC, whose work during his postdoctoral fellowship with David Baker played a crucial role in this achievement.<\/p>\n

\"Dr.
Brian Kuhlman PhD, Professor of Biochemistry and Biophysics and Oliver Smithies Investigator<\/figcaption><\/figure>\n<\/div>\n
\n

Dr. Kuhlman’s contributions are referenced in the Nobel Prize documentation, specifically in reference #17, which details the breakthrough in computational de novo protein design. In 2003, David Baker and his team, including Dr. Kuhlman, published the design and crystallographic validation of a 93-residue \u03b1\/\u03b2-protein named Top7. This pioneering work laid the foundation for advancements in protein design and has had a lasting impact on the field of chemistry.<\/p>\n<\/div>\n

\n
\n

Dr. Kuhlman said, “I am super excited for David Baker and all the people that have contributed to our field.\u00a0 For me personally, it was neat to see Top7 and Rosetta mentioned in the Nobel Prize write-up.\u00a0 The time I spent in David\u2019s lab developing the protein design module in Rosetta and designing Top7 was incredibly fun and rewarding.\u00a0 Equally exciting has been seeing all the wonderful proteins that people have designed using Rosetta and now even more powerful AI-based methods.\u00a0 These include new vaccines, enzymes and therapeutic proteins”<\/span><\/p>\n<\/blockquote>\n<\/div>\n

\n

We extend our heartfelt\u00a0congratulations<\/span> to Dr. Brian Kuhlman, for his remarkable achievement, being mentioned as the first author\u00a0on\u00a0one of the key publications\u00a0that led to the Nobel Prize. This recognition underscores the importance of collaborative research and the significant contributions of our faculty to scientific innovation. Read more about this incredible achievement\u00a0\u00a0https:\/\/www.nobelprize.org\/uploads\/2024\/10\/advanced-chemistryprize2024.pdf<\/a><\/p>\n

\"Kuhlman
\nKuhlman lab website<\/a><\/p>\n

Additional links:<\/p>\n

The Nobel Prize website press release for the 2024 Chemistry prize<\/a><\/p>\n

NobelPrize.org<\/a> The Nobel Prize in Chemistry<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Special recognition to Dr. Brian Kuhlman at UNC, whose work during his postdoc with David Baker contributed to this groundbreaking achievement. Dr. Kuhlman’s contributions are referenced in the Nobel Prize documentation, see Ref. #17 is Kuhlman et al. From page 7 Nobel Prize doc. “The breakthrough in computational de novo protein design came in 2003 when David Baker and coworkers published the design and crystallographic validation of a 93-residue \u03b1\/\u03b2-protein named Top7.\u201d read more…<\/p>\n","protected":false},"author":41619,"featured_media":29827,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,394],"class_list":["post-29824","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2024","odd"],"acf":[],"yoast_head":"\n2024 Nobel Prize in Chemistry Honors Work Linked to UNC Scientist: Dr. Brian Kuhlman | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/2024-nobel-prize-in-chemistry-honors-work-linked-to-unc-scientist-dr-brian-kuhlman\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"2024 Nobel Prize in Chemistry Honors Work Linked to UNC Scientist: Dr. Brian Kuhlman | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Special recognition to Dr. Brian Kuhlman at UNC, whose work during his postdoc with David Baker contributed to this groundbreaking achievement. Dr. Kuhlman's contributions are referenced in the Nobel Prize documentation, see Ref. #17 is Kuhlman et al. From page 7 Nobel Prize doc. 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