{"id":32414,"date":"2025-11-03T07:53:59","date_gmt":"2025-11-03T12:53:59","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=32414"},"modified":"2025-11-06T08:11:16","modified_gmt":"2025-11-06T13:11:16","slug":"researchers-in-our-labs-unlock-new-way-to-help-fight-skin-cancer","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-in-our-labs-unlock-new-way-to-help-fight-skin-cancer\/","title":{"rendered":"Researchers in our labs Unlock New Way to Help Fight Skin Cancer"},"content":{"rendered":"<p><span class=\"TextRun SCXW242986233 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW242986233 BCX8\">We have thrilling research news from Drs.\u00a0<\/span><span class=\"NormalTextRun SCXW242986233 BCX8\">Pengda<\/span><span class=\"NormalTextRun SCXW242986233 BCX8\">\u00a0Liu and Pietro Dotti:\u00a0<\/span><\/span><a class=\"Hyperlink SCXW242986233 BCX8\" href=\"https:\/\/news.unchealthcare.org\/2025\/10\/unc-researchers-unlock-new-way-to-help-fight-skin-cancer\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"TextRun Underlined SCXW242986233 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW242986233 BCX8\" data-ccp-charstyle=\"Hyperlink\">UNC Researchers Unlock New Way to Help Fight Skin Cancer<\/span><\/span><\/a><span class=\"TextRun SCXW242986233 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW242986233 BCX8\">. Drs. Liu and Dotti have recently\u00a0<\/span><span class=\"NormalTextRun SCXW242986233 BCX8\">identified<\/span><span class=\"NormalTextRun SCXW242986233 BCX8\">\u00a0and tested a small molecule that significantly enhances the effectiveness of immunotherapies and CAR T-cell therapy in combating advanced melanoma. This discovery is especially important, considering that chemotherapy is successful in less than half of melanoma patients. The research team is now focusing on further studying this small molecule and exploring biomedical devices that can provide extended release of these therapies,\u00a0<\/span><span class=\"NormalTextRun SCXW242986233 BCX8\">similar to<\/span><span class=\"NormalTextRun SCXW242986233 BCX8\">\u00a0the continuous glucose monitors used by people with diabetes.<\/span><\/span><span class=\"EOP SCXW242986233 BCX8\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\n<p>Read more at the link above.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers found that inhibiting a problematic protein in the body helps immunotherapies and CAR T-cell therapy to better fight off melanoma.<\/p>\n","protected":false},"author":41619,"featured_media":29935,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,179],"class_list":["post-32414","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_postdoc-scholars","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Researchers in our labs Unlock New Way to Help Fight Skin Cancer | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-in-our-labs-unlock-new-way-to-help-fight-skin-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers in our labs Unlock New Way to Help Fight Skin Cancer | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Researchers found that inhibiting a problematic protein in the body helps immunotherapies and CAR T-cell therapy to better fight off melanoma.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-in-our-labs-unlock-new-way-to-help-fight-skin-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-03T12:53:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-06T13:11:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/10\/Pengda-Liu-PhD-2021.png\" \/>\n\t<meta property=\"og:image:width\" content=\"624\" \/>\n\t<meta property=\"og:image:height\" content=\"796\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-in-our-labs-unlock-new-way-to-help-fight-skin-cancer\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-in-our-labs-unlock-new-way-to-help-fight-skin-cancer\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"Researchers in our labs Unlock New Way to Help Fight Skin Cancer\",\"datePublished\":\"2025-11-03T12:53:59+00:00\",\"dateModified\":\"2025-11-06T13:11:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-in-our-labs-unlock-new-way-to-help-fight-skin-cancer\/\"},\"wordCount\":119,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-in-our-labs-unlock-new-way-to-help-fight-skin-cancer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2024\/10\/Pengda-Liu-PhD-2021.png\",\"keywords\":[\"Faculty &amp; 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