{"id":32704,"date":"2026-03-02T10:10:26","date_gmt":"2026-03-02T15:10:26","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=32704"},"modified":"2026-03-03T11:02:36","modified_gmt":"2026-03-03T16:02:36","slug":"science-persistence-and-firsts-the-life-of-mary-ellen-jones","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/science-persistence-and-firsts-the-life-of-mary-ellen-jones\/","title":{"rendered":"Science, Persistence, and Firsts: The Life of Mary Ellen Jones"},"content":{"rendered":"
\n
\"\"<\/a>
A headshot of Mary Ellen Jones, PhD, a snippet from one of her scientific papers, and the building that would eventually bear her name.<\/figcaption><\/figure>\n

In an era when it was difficult for women to advance, Mary Ellen Jones, PhD, was the first woman to chair a department at the UNC School of Medicine and the first woman to be named a Kenan Distinguished Professor.<\/p>\n

Jones devoted her career to studying enzymes involved in amino acid and nucleic acid metabolism for more than fifty years. One of her many scientific achievements was her discovery of carbamoyl phosphate, a compound that is essential for the creation of cytosine, thymine, and uracil \u2013 the very building blocks that make up our DNA and RNA.<\/p>\n

The discovery of carbamoyl phosphate was truly significant. Not only did the finding rapidly influence research in many other laboratories, but her studies also laid the foundation for basic cancer research, said the\u00a0New York Times<\/em>, who\u00a0called her<\/a>\u00a0a \u201ccrucial researcher on DNA\u201d in a 1996 feature story.<\/p>\n

Over time, enzymes like Cathepsin C, dihydroorotate synthase, UMP synthase, carbamoyl phosphate, and many other enzymes fell under her inquisitive eye. She was one of the first scientists to study multifunctional enzymes. You can\u00a0read more<\/a>\u00a0about her contributions to science in a biographical memoir, written by the National Academies Press.<\/p>\n

\u201cJones\u2019 pioneering work on carbamoyl phosphate revolutionized the field and illuminated the pathways involved in DNA and RNA synthesis inside our cells,\u201d said Blossom Damania, vice dean for research at UNC School of Medicine. \u201cHer accomplishments as a scientific leader and as the very first woman chair in the School of Medicine lives on at UNC. Indeed, the Mary Ellen Jones building on our campus is a tribute to her amazing legacy.\u201d<\/p>\n

How Her Legendary Science Career Began<\/strong><\/p>\n

Mary Ellen Jones was born on December 25, 1922, in La Grange, Illinois. She was one of four children of Elmer and Laura Klein Jones. She received an undergraduate degree from the University of Chicago in 1944 and worked at Armour and Company until 1948.<\/p>\n

\"\"
View of Armour & Company\u2019s plant and stock yards from a balloon, c. 1910<\/figcaption><\/figure>\n

It was at Armour and Company where she met Paul Munson, who then was director of the research laboratory. With Munson she would do her first research on androsterone and monopalmitin, leading to two publications in the\u00a0Journal of Biological Chemistry<\/em>. Jones and Munson married in 1948 and had two children, but ultimately divorced in 1971.<\/p>\n

Jones enrolled at Yale University in 1948 for graduate school, quickly realizing that enzymology was extremely fascinating. She said that each enzyme \u201cdevelops a character uniquely its own.\u201d<\/p>\n

Under the direction of Joseph Fruton, an assistant professor in the Department of Physiological Chemistry at the Medical School at Yale, she completed her dissertation titled \u201cPurification & Properties of Cathepsin C\u201d in just three years and graduated in 1951. Jones become one of Yale\u2019s\u00a0most distinguished alumni<\/a>\u00a0and the namesake of the department\u2019s dissertation prize.<\/p>\n

Jones Leaves Mark on UNC Campus<\/strong><\/p>\n

When Paul Munson was offered the chair of pharmacology at the University of North Carolina at Chapel Hill in 1966, Jones relocated to UNC\u2019s Department of Biochemistry, where she became professor in 1968.<\/p>\n

\"\"
The Mary Ellen Jones Building, which resides on the campus of the University of North Carolina \u2013 Chapel Hill.<\/figcaption><\/figure>\n

Jones continued to show a spirit for pursuing new directions and new technologies throughout her late sixties. She was elected to the Institute of Medicine in 1981, the National Academy of Sciences in 1984, and the American Academy of Arts and Sciences in 1991. She retired in 1995, soon after being diagnosed with esophageal cancer. She died on August 23, 1996.<\/p>\n

Jones was widely recognized for her scientific accomplishments and for her leadership roles. Among her awards were the Wilbur Lucius Cross Medal from Yale University (1982),\u00a0the North Carolina American Chemical Society<\/a>\u00a0Distinguished Chemist (1986), the\u00a0Thomas Jefferson Award<\/a>\u00a0from the University of North Carolina (1990), and the Award in Science awarded by the state of North Carolina (1991). She was also honored by having an 11-story research center dedicated with her name at 116 Manning Drive, Chapel Hill, North Carolina.<\/p>\n","protected":false},"excerpt":{"rendered":"

We would like to honor Mary Ellen Jones, PhD. You may recognize her name from the building that sits on the edge of the UNC Medical Center campus, but Jones is recognized for so much more.<\/p>\n","protected":false},"author":41619,"featured_media":25777,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,179,13],"class_list":["post-32704","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_postdoc-scholars","tag-news_students","odd"],"acf":[],"yoast_head":"\nScience, Persistence, and Firsts: The Life of Mary Ellen Jones | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/science-persistence-and-firsts-the-life-of-mary-ellen-jones\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Science, Persistence, and Firsts: The Life of Mary Ellen Jones | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"We would like to honor Mary Ellen Jones, PhD. 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