{"id":3952,"date":"2011-09-08T18:55:00","date_gmt":"2011-09-08T22:55:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/jin-lee-is-recipient-of-a-2011-geab-impact-award\/"},"modified":"2018-08-01T10:21:45","modified_gmt":"2018-08-01T14:21:45","slug":"jin-lee-is-recipient-of-a-2011-geab-impact-award","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/jin-lee-is-recipient-of-a-2011-geab-impact-award\/","title":{"rendered":"Grad Student Jin Hyup Lee receives a 2011 GEAB Impact Award"},"content":{"rendered":"<div>\n<p class=\"lead\">\u201cI believe Jin has a great future in cancer biology and his research is likely to have an immediate impact on the health and welfare of the people of North Carolina,\u201d said Aziz Sancar, M.D., Ph.D., Lee\u2019s dissertation adviser.  Jin is currently a graduate student in the Department of Biochemistry &amp; Biophysics.<\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\">\n    <img loading=\"lazy\" decoding=\"async\" class=\"size-medium size-full wp-image-3953\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/jin-lee-is-recipient-of-a-2011-geab-impact-award-image2.jpeg\" width=\"300\" height=\"200\" alt=\"image2\"\/><figcaption class=\"caption wp-caption-text\">Jin Hyup Lee<br \/>\n    <\/figcaption><\/figure>\n<\/div>\n<div>\n<p style=\"text-align: justify; \">Sponsored by UNC-Chapel Hill Graduate School\u2019s Graduate Education Advancement Board, the Impact Awards recognize graduate students whose research provides special benefits to the citizens of North Carolina. That impact can be basic as well as applied. It can have a direct impact on the citizens of North Carolina (and beyond) or a more indirect impact through new knowledge or insights gained, educational, economic, health, social and cultural, or environmental effects that will be derived from the research endeavor.<\/p>\n<p style=\"text-align: justify; \">Jin Hyup Lee, doctoral student of Biochemistry &amp; Biophysics, is currently working on \u201cTreating Cancer by Tinkering with the Clock E\u201d in the lab of Dr. Aziz Sancar, Distinguished Professor Biochemistry &amp; Biophysics. Lee\u2019s research lends support for the development of drugs as targeted therapies for the treatment of cancers with dysfunctional p53 protein, which has the potential to improve the health of citizens in North Carolina and beyond.<\/p>\n<p style=\"text-align: justify; \"><a class=\"external-link\" href=\"http:\/\/gradschool.unc.edu\/student\/awards\/impact\/2011.html\">Learn more about the G.E.A.B. Impact Awards and other recipients.<\/a><\/p>\n<hr\/>\n<p><i><b>Treating Cancer by Tinkering with the Clock E<\/b><\/i><\/p>\n<p style=\"text-align: justify; \">Cancer is the leading cause of death in North Carolina, and death rates from cancer have been escalating since the early 1980s. One of the most significant advances in cancer prevention and treatment in recent years has been recognition of the importance of apoptosis, or programmed cell death, which provides new opportunities for the discovery of cancer therapeutic targets and agents. The protein tumor suppressor p53 plays a critical role in apoptosis induced by anticancer drugs; however, at least 50 percent of human cancers lack functional p53. Lee discovered that disrupting the circadian clock\u2014the major regulatory system that ensures proper adaptation to the constantly changing environment\u2014functionally activates the p73 tumor suppressor protein, which induces cell death in p53-deficient cancer cells. His study indicates that this mechanism provides another way to overcome the resistance to apoptosis of cancer cells selectively.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>\u201cI believe Jin has a great future in cancer biology and his research is likely to have an immediate impact on the health and welfare of the people of North Carolina,\u201d said Aziz Sancar, M.D., Ph.D., Lee&#8217;s dissertation adviser.  Jin is currently a graduate student in the Department of Biochemistry &#038; Biophysics.<\/p>\n","protected":false},"author":12066,"featured_media":3953,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[16,13],"class_list":["post-3952","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_2011","tag-news_students","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Grad Student Jin Hyup Lee receives a 2011 GEAB Impact Award | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/jin-lee-is-recipient-of-a-2011-geab-impact-award\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Grad Student Jin Hyup Lee receives a 2011 GEAB Impact Award | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"\u201cI believe Jin has a great future in cancer biology and his research is likely to have an immediate impact on the health and welfare of the people of North Carolina,\u201d said Aziz Sancar, M.D., Ph.D., Lee&#039;s dissertation adviser. 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