{"id":4053,"date":"2014-01-10T14:25:00","date_gmt":"2014-01-10T19:25:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/a-powerful-technique-to-further-understanding-of-rna\/"},"modified":"2018-08-01T10:26:37","modified_gmt":"2018-08-01T14:26:37","slug":"a-powerful-technique-to-further-understanding-of-rna","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/a-powerful-technique-to-further-understanding-of-rna\/","title":{"rendered":"A powerful technique to further understanding of RNA"},"content":{"rendered":"
\n

In a paper published by JACS, Qi Zhang, an assistant professor of biochemistry and biophysics and member of the UNC Lineberger Comprehensive Cancer Center, and his team have revealed his newest weapon \u2013 a powerful technique to visualize the shape and motion of RNA at the atomic level using nuclear magnetic resonance spectroscopy (NMR).<\/p>\n

\n
\n \"image2\"\/
Qi Zhang, PhD
\n <\/figcaption><\/figure>\n
\n \"image3\"\/
Bo Zhao, PhD
\n <\/figcaption><\/figure>\n<\/div>\n
\n

By providing researchers with the ability to visualize RNA as it changes shape over timescales ranging from hundredths to tenths of a second, Zhang said his team has developed a tool that can help researchers better understand the nucleic acid and assist in the development of new drugs for diseases with a genetic basis such as cancer.<\/p>\n

RNA is very simple chemically, with a structure much like that of DNA. This molecule can fold in numerous ways, changing shape dramatically depending on the role it is playing. With NMR, researchers can follow those structural changes in order to visualize RNA\u2019s composition across time, important when designing drugs that will bind to the nucleic acid at exactly the right moment.<\/p>\n

\u201cThe reason we want the atomic level, practically, is that if you want to design small molecule therapeutics to try to inhibit a state or enhance a function, it is every single atom by atom interaction that is important,\u201d said Zhang. \u201cThere are similar techniques in protein work. Our technique provides the nucleic acid field a very powerful approach, a tool, to be able to look into this particular timescale \u2013 at milliseconds or slower.\u201d<\/p>\n

\"RNA<\/p>\n

Structural biologists currently understand RNA as a series of static figures. How it shifts form while performing different functions has been difficult to examine with existing techniques, but the molecules of RNA can change structure radically depending on what role it is playing within an organism. What Zhang\u2019s NMR techniques introduce to the field is an ability to visualize the structure as a shape in motion, transforming as it fulfills its role.<\/p>\n

\u201cStructural biologists give atomic-level insights into what RNA does at a particular moment, but in order to understand how it carries out a variety of functions during the entire biological process, you need to look at the transition between different distinct structures. That\u2019s what we want to do. We want to see those things,\u201d said Zhang. <\/p>\n

The importance to RNA in biology and drug development has expanded as researchers realize the extent of its importance in biological functions. RNA was once understood as a single-purpose machine that read the code within DNA and assembled it into the numerous proteins that form the workhorses of the cellular world. <\/p>\n

As understanding of genetics and genomics has increased, researcher realized that RNA played a greater role in biology, especially in complex species like human beings. Only about 1.5 percent of human genome is coding for proteins. The rest is coding for RNA. <\/p>\n

\u201cThis means that there are a lot of RNA-based functions \u2013 many that we do not currently know,\u201d said Zhang.<\/p>\n

RNA can fulfill numerous roles within a cell beyond protein assembly, including acting as enzymes to catalyze biological reactions, communicating cellular signals, controlling which genes are expressed. It can even function as an information carrier itself in the absence of DNA within viruses.<\/p>\n

\u201cWe always think proteins are the center of biology. Over the last decade or two, RNA has been getting back to the center stage,\u201d said Zhang.<\/p>\n

While Zhang\u2019s work will help deepen the basic understanding of RNA\u2019s role in biology for other researchers, it remains for him a weapon. His lab is already using NMR to assist with the creation of new therapies for cancer, heart disease and other conditions that originate when folding mistakes in RNA cascade into disease. For other researchers, he hopes that his technique can provide a powerful tool for furthering their aims, be it war or understanding.<\/p>\n

\u201cThey can use this to study basic chemical and physical properties of RNA. They can study RNA biology. They can use it to study the atomic foundation to develop drugs. I think this technique is going to be very powerful,\u201d said Zhang.<\/p>\n

The paper coauthors are Bo Zhao of the UNC Department of Chemistry and Alexandar Hansen of the University of Toronto. Research was supported by grants from the National Science Foundation (OISE-0852964), the March of Dimes Foundation and the Canadian Institutes of Health Research, as well as start-up funding from the University of North Carolina.<\/p>\n

Link to paper<\/a><\/p>\n

Link to Lineberger News<\/a><\/p>\n

Link to Vital Signs<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

In a paper published by JACS, Qi Zhang, an assistant professor of biochemistry and biophysics and member of the UNC Lineberger Comprehensive Cancer Center, and his team have revealed his newest weapon \u2013 a powerful technique to visualize the shape and motion of RNA at the atomic level using nuclear magnetic resonance spectroscopy (NMR).<\/p>\n","protected":false},"author":37803,"featured_media":4054,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,21,20,4],"class_list":["post-4053","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-jan_2014","tag-news_2014","tag-recent-news","odd"],"acf":[],"yoast_head":"\nA powerful technique to further understanding of RNA | Biochemistry and 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