{"id":4098,"date":"2017-07-03T16:15:00","date_gmt":"2017-07-03T20:15:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/bergmeier-blood-advances-cover\/"},"modified":"2018-08-01T10:28:01","modified_gmt":"2018-08-01T14:28:01","slug":"bergmeier-blood-advances-cover","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/bergmeier-blood-advances-cover\/","title":{"rendered":"Bergmeier Blood Advances cover"},"content":{"rendered":"<div>\n<p class=\"lead\">Blood Advances From the cover. Bergmeier lab image has been selected for the cover of Blood Advances 1:18 issue.<\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\">\n    <img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-4099\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/bergmeier-blood-advances-cover-image2-229x300.jpeg\" width=\"300\" height=\"200\" alt=\"image2\"\/><figcaption class=\"caption wp-caption-text\">Bergmeier Blood Advances cover<br \/>\n    <\/figcaption><\/figure>\n<\/div>\n<div class=\"plain\" id=\"parent-fieldname-text\">\n<div class=\"plain\" id=\"parent-fieldname-text\">\n<p>The Bergmeier lab studies the biology of platelets and their precursor cells, megakaryocytes. Special credit for this cover image goes to Dorsaf Ghalloussi, who established the required imaging technique in the lab, and David Paul, the lead author of the study who acquired the image. <\/p>\n<\/div>\n<div>In the image you see blood vessels in red, megakaryocytes and platelets in green, nuclei in blue \u2013 image from a bone marrow whole mount.<\/div>\n<div><strong>Brief description of the science<\/strong><\/div>\n<div>The actin cytoskeleton is a key regulator of various cellular functions. To examine the role of the Arp2\/3 complex, an essential component in actin filament branching, in platelet biology, Bergmeier lab analyzed mice lacking the p34 subunit of the Arp2\/3 complex specifically in platelets and their precursor cells, megakaryocytes. Deletion of the Arp2\/3 complex in mice resulted in marked microthrombocytopenia (smaller and fewer platelets), a finding that is consistent with the very recent description of microthrombocytopenia in patients with defects in the Arp2\/3 complex. Bergmeier lab mechanistic studies demonstrate that the decrease in circulating platelets is due to altered platelet release in the bone marrow and impaired platelet survival in circulation. <span style=\"color: rgb(50, 50, 50); background-color: rgb(255, 255, 255); \">Arp2\/3 deficient<\/span> platelets exhibited alterations in their actin cytoskeleton and their peripheral microtubule coil, changes that may contribute to faster clearance of these cells by macrophages of the spleen and the liver. <span style=\"color: rgb(50, 50, 50); background-color: rgb(255, 255, 255); \">Arp2\/3 deficient<\/span> platelets failed to spread and showed a mild defect in integrin-mediated aggregation. However, these mild functional defects did not impair the ability of these cells to prevent blood loss at sites of vascular injury. In summary, Bergmeier lab studies identify a critical role for the Arp2\/3 complex, and thus actin filament branching, in platelet release from megakaryocytes and platelet survival in circulation.  <\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>Blood Advances From the cover. Bergmeier lab image has been selected for the cover of Blood Advances 1:18 issue.<\/p>\n","protected":false},"author":41619,"featured_media":4099,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[34,30,10,28,33,4],"class_list":["post-4098","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-2017-faculty-year-in-review","tag-2017-year-in-review","tag-news_faculty","tag-news_2017","tag-news_faculty_s17","tag-recent-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Bergmeier Blood Advances cover | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/bergmeier-blood-advances-cover\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bergmeier Blood Advances cover | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Blood Advances From the cover. Bergmeier lab image has been selected for the cover of Blood Advances 1:18 issue.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/bergmeier-blood-advances-cover\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-07-03T20:15:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-08-01T14:28:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/bergmeier-blood-advances-cover-image2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"605\" \/>\n\t<meta property=\"og:image:height\" content=\"793\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/bergmeier-blood-advances-cover\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/bergmeier-blood-advances-cover\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"Bergmeier Blood Advances cover\",\"datePublished\":\"2017-07-03T20:15:00+00:00\",\"dateModified\":\"2018-08-01T14:28:01+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/bergmeier-blood-advances-cover\/\"},\"wordCount\":307,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/bergmeier-blood-advances-cover\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/bergmeier-blood-advances-cover-image2.jpeg\",\"keywords\":[\"2017-faculty-year-in-review\",\"2017-Year-in-Review\",\"Faculty &amp; 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