{"id":4205,"date":"2018-02-08T18:00:00","date_gmt":"2018-02-08T23:00:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/"},"modified":"2018-08-01T10:31:39","modified_gmt":"2018-08-01T14:31:39","slug":"gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/","title":{"rendered":"Gene therapy researchers find viral barcode to cross the blood-brain barrier"},"content":{"rendered":"
\n

Congratulations to Aravind Asokan PhD, Assistant Professor of Genetics with a Joint Appointment in Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center member who led UNC scientists to reveal how certain gene-carrying AAV vectors can penetrate the brain more efficiently to treat brain and spinal cord conditions, while reducing liver payload.<\/p>\n

\n
\n \"image2\"\/
Aravind Asokan, PhD
\n <\/figcaption><\/figure>\n
\n \"image3\"\/
This image shows AAV therapy affecting pyramidal neurons in the hippocampus. (Blake Albright, Asokan Lab)
\n <\/figcaption><\/figure>\n<\/div>\n
\n

Gene therapies promise to revolutionize the treatment of many diseases, including neurological diseases such as ALS. But the small viruses that deliver therapeutic genes can have adverse side effects at high doses. UNC School of Medicine researchers have now found a structure on these viruses that makes them better at crossing from the bloodstream into the brain \u2013 a key factor for administering gene therapies at lower doses for treating brain and spinal disorders.<\/p>\n

\u201cThis structural \u2018footprint\u2019 we found seems to help these viruses get efficiently into the brain, which informs the design of potentially safer brain-targeted gene therapies,\u201d said study senior author Aravind Asokan, PhD, associate professor of genetics with a Joint Appointment in Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center member<\/span>.<\/p>\n

The study, published in Molecular Therapy<\/i>, examined adeno-associated viruses (AAVs), the most commonly used virus vectors for delivering gene therapies. The natural forms of these small viruses normally infect people without causing disease. For gene therapies, scientists remove most of the AAV genome, replace it with therapeutic genetic cargo, and inject trillions of copies into the patient.<\/p>\n

In principle, scientists can modify AAVs to infect some cell types more than others to deliver their therapeutic payloads where they are most needed. However, most AAVs cannot easily cross from the bloodstream into the brain. Like most other viruses, they tend to be blocked by the cells that tightly line brain capillaries to form the so-called blood-brain barrier.<\/p>\n

\u201cTo achieve therapeutic effects in the brain, AAVs sometimes have to be given in high doses, which raises the possibility of dose-dependent toxicity,\u201d said first author Blake Albright<\/a>, a graduate research assistant at UNC.<\/p>\n

For the study, Albright, Asokan <\/a>and colleagues tried to isolate the features that enable AAVs to cross the blood-brain barrier more easily. They started with two known AAVs, one that doesn\u2019t efficiently cross the blood-brain barrier, and one that does. They created a small library of new variants of these AAVs by swapping short stretches of DNA from one to the other. They then tested these for their ability to cross the blood-brain barrier in mice.<\/p>\n

In this way they isolated a closely spaced set of just eight amino acids on the viral coating that confers the ability to cross the blood-brain barrier efficiently. \u201cGrafting that structural footprint onto another AAV strain enables it to cross into the brain much more easily,\u201d Albright said.<\/p>\n

The finding suggests that other AAVs used for a gene therapy targeting the brain or spinal cord might be improved by having the same or a similar set of amino acids. It would cross the blood-brain barrier more efficiently, and thus in principle would require a smaller dose to achieve therapeutic effects in the brain.<\/p>\n

A smaller AAV dose would in itself mean a smaller chance of adverse side effects. But the UNC scientists found another potential safety benefit. Compared to their parental strains, AAV variants containing the key set of amino acids were less likely to get into other, non-brain cells, including liver cells. Transient liver toxicity is a significant concern in gene therapy when high doses are required.<\/p>\n

\u201cWe also found that our AAV variants containing this key amino acid footprint preferentially get into neurons rather than other brain cell types,\u201d Asokan said. \u201cThis could be particularly useful for some gene therapies that target the brain.\u201d<\/p>\n

Gene therapies against neurological diseases are under investigation in clinical and preclinical trials, and include therapies for ALS, Huntington\u2019s disease, Spinal Muscular Atrophy, Friedrich\u2019s ataxia, and other disorders.<\/p>\n

Researchers at Asokan Lab<\/a> are now trying to determine the precise molecular details of how the set of AAV amino acids allows the viruses to cross the blood-brain barrier. They are also studying how structures that enable blood-brain barrier crossing might differ from one animal species to another.<\/p>\n

The National Institutes of Health funded this work.<\/i><\/p>\n\n

Courtesy of Mark Derewicz<\/a>, UNC Healthcare Communications Manager
BCBP Media contact: Carolyn M. Clabo, 919-962-7642, carolyn_clabo@med.unc.edu<\/em><\/span><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

Congratulations to Aravind Asokan PhD, Assistant Professor of Genetics with a Joint Appointment in Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center member who led UNC scientists to reveal how certain gene-carrying AAV vectors can penetrate the brain more efficiently to treat brain and spinal cord conditions, while reducing liver payload.<\/p>\n","protected":false},"author":41619,"featured_media":4206,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,36,3,37,4],"class_list":["post-4205","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2018","tag-news_dept","tag-news_faculty_s18","tag-recent-news","odd"],"acf":[],"yoast_head":"\nGene therapy researchers find viral barcode to cross the blood-brain barrier | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene therapy researchers find viral barcode to cross the blood-brain barrier | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Congratulations to Aravind Asokan PhD, Assistant Professor of Genetics with a Joint Appointment in Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center member who led UNC scientists to reveal how certain gene-carrying AAV vectors can penetrate the brain more efficiently to treat brain and spinal cord conditions, while reducing liver payload.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-02-08T23:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-08-01T14:31:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"188\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"Gene therapy researchers find viral barcode to cross the blood-brain barrier\",\"datePublished\":\"2018-02-08T23:00:00+00:00\",\"dateModified\":\"2018-08-01T14:31:39+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/\"},\"wordCount\":743,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg\",\"keywords\":[\"Faculty & Lab News\",\"News 2018\",\"news_dept\",\"News_Faculty_S18\",\"recent news\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/\",\"name\":\"Gene therapy researchers find viral barcode to cross the blood-brain barrier | Biochemistry and Biophysics\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg\",\"datePublished\":\"2018-02-08T23:00:00+00:00\",\"dateModified\":\"2018-08-01T14:31:39+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg\",\"width\":188,\"height\":250,\"caption\":\"Aravind Asokan, PhD\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/biochem\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Gene therapy researchers find viral barcode to cross the blood-brain barrier\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"name\":\"UNC Biochemistry and Biophysics\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\",\"name\":\"UNC Department of Biochemistry and Biophysics\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"width\":488,\"height\":400,\"caption\":\"UNC Department of Biochemistry and Biophysics\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\",\"https:\/\/x.com\/UNC_BCBP\",\"https:\/\/www.instagram.com\/unc_bcbp\/\",\"https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\",\"name\":\"Carolyn Clabo\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"caption\":\"Carolyn Clabo\"},\"description\":\"Biochemistry & Biophysics - Communications & Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology & Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement & Univ. Development (former)\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Gene therapy researchers find viral barcode to cross the blood-brain barrier | Biochemistry and Biophysics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/","og_locale":"en_US","og_type":"article","og_title":"Gene therapy researchers find viral barcode to cross the blood-brain barrier | Biochemistry and Biophysics","og_description":"Congratulations to Aravind Asokan PhD, Assistant Professor of Genetics with a Joint Appointment in Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center member who led UNC scientists to reveal how certain gene-carrying AAV vectors can penetrate the brain more efficiently to treat brain and spinal cord conditions, while reducing liver payload.","og_url":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/","og_site_name":"Biochemistry and Biophysics","article_publisher":"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","article_published_time":"2018-02-08T23:00:00+00:00","article_modified_time":"2018-08-01T14:31:39+00:00","og_image":[{"width":188,"height":250,"url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg","type":"image\/jpeg"}],"author":"Carolyn Clabo","twitter_card":"summary_large_image","twitter_creator":"@UNC_BCBP","twitter_site":"@UNC_BCBP","twitter_misc":{"Written by":"Carolyn Clabo","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/"},"author":{"name":"Carolyn Clabo","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332"},"headline":"Gene therapy researchers find viral barcode to cross the blood-brain barrier","datePublished":"2018-02-08T23:00:00+00:00","dateModified":"2018-08-01T14:31:39+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/"},"wordCount":743,"publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg","keywords":["Faculty & Lab News","News 2018","news_dept","News_Faculty_S18","recent news"],"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/","url":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/","name":"Gene therapy researchers find viral barcode to cross the blood-brain barrier | Biochemistry and Biophysics","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg","datePublished":"2018-02-08T23:00:00+00:00","dateModified":"2018-08-01T14:31:39+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#primaryimage","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg","width":188,"height":250,"caption":"Aravind Asokan, PhD"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/biochem\/"},{"@type":"ListItem","position":2,"name":"Gene therapy researchers find viral barcode to cross the blood-brain barrier"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/biochem\/#website","url":"https:\/\/www.med.unc.edu\/biochem\/","name":"UNC Biochemistry and Biophysics","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/biochem\/#organization","name":"UNC Department of Biochemistry and Biophysics","url":"https:\/\/www.med.unc.edu\/biochem\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","width":488,"height":400,"caption":"UNC Department of Biochemistry and Biophysics"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","https:\/\/x.com\/UNC_BCBP","https:\/\/www.instagram.com\/unc_bcbp\/","https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/"]},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332","name":"Carolyn Clabo","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","caption":"Carolyn Clabo"},"description":"Biochemistry & Biophysics - Communications & Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology & Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement & Univ. Development (former)","url":"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg","featured_image_medium":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg","featured_image_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2.jpeg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/gene-therapy-researchers-find-viral-barcode-to-cross-the-blood-brain-barrier-image2-150x199.jpeg","featured_image_alt":"Aravind Asokan, PhD","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/biochem\/category\/news\/"}],"tag_details":[{"name":"Faculty & Lab News","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_faculty\/"},{"name":"News 2018","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_2018\/"},{"name":"news_dept","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_dept\/"},{"name":"News_Faculty_S18","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_faculty_s18\/"},{"name":"recent news","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/recent-news\/"}],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/4205","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/users\/41619"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/comments?post=4205"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/4205\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media\/4206"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media?parent=4205"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/categories?post=4205"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/tags?post=4205"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}