{"id":4328,"date":"2015-06-02T21:15:00","date_gmt":"2015-06-03T01:15:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/new-evidence-emerges-on-the-origins-of-life-on-earth\/"},"modified":"2018-08-01T10:35:46","modified_gmt":"2018-08-01T14:35:46","slug":"new-evidence-emerges-on-the-origins-of-life-on-earth","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/new-evidence-emerges-on-the-origins-of-life-on-earth\/","title":{"rendered":"New evidence emerges on the origins of life on Earth"},"content":{"rendered":"
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University of North Carolina researchers provide evidence for how the genetic code developed in two distinct stages to help primordial chemicals evolve into cells.<\/p>\n

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CHAPEL HILL, NC \u2013 In the beginning, there were simple chemicals. And they produced amino acids that eventually became the proteins necessary to create single cells. And the single cells became plants and animals. Recent research is revealing how the primordial soup created the amino acid building blocks, and there is widespread scientific consensus on the evolution from the first cell into plants and animals. But it\u2019s still a mystery how the building blocks were first assembled into the proteins that formed the machinery of all cells. Now, two long-time University of North Carolina scientists \u2013 Richard Wolfenden, PhD, and Charles Carter, PhD \u2013 have shed new light on the transition from building blocks into life some 4 billion years ago.<\/span><\/p>\n

Their findings, published in companion papers in the Proceedings of the National Academy of Sciences<\/i>, fly in the face of the problematic \u201cRNA world\u201d theory, which posits that RNA \u2013 the molecule that today plays roles in coding, regulating, and expressing genes \u2013 elevated itself<\/i> from the primordial soup of amino acids and cosmic chemicals to give rise first to short proteins called peptides and then to single-celled organisms. Wolfenden and Carter argue that RNA did not work alone; in fact, it was no more likely that RNA catalyzed peptide formation than it was for peptides to catalyze RNA formation. \u201cOur work shows that the close linkage between the physical properties of amino acids, the genetic code, and protein folding was likely essential from the beginning, long before large, sophisticated molecules arrived on the scene,\u201d said Carter, professor of biochemistry and biophysics at the UNC School of Medicine. \u201cThis close interaction was likely the key factor in the evolution from building blocks to organisms.\u201d<\/span><\/p>\n

The finding adds a new layer to the story of how life evolved billions of years ago.<\/span><\/p>\n

Its name was LUCA<\/b><\/span><\/p>\n

The scientific community recognizes that 3.6 billion years ago there existed the last universal common ancestor, or LUCA, of all living things presently on Earth. It was likely a single-cell organism. It had a few hundred genes. It already had complete blueprints for DNA replication, protein synthesis, and RNA transcription. It had all the basic components \u2013 such as lipids \u2013 that modern organisms have. From LUCA forward, it\u2019s relatively easy to see how life as we know it evolved.<\/span><\/p>\n

Before 3.6 billion years, however, there is no hard evidence about how LUCA arose from a boiling caldron of chemicals that formed on Earth after the creation of the planet about 4.6 billion years ago. Those chemicals reacted to form amino acids, which remain the building blocks of proteins in our own cells today. \u201cWe know a lot about LUCA and we are beginning to learn about the chemistry that produced building blocks like amino acids, but between the two there is a desert of knowledge,\u201d Carter said. \u201cWe haven\u2019t even known how to explore it.\u201d The UNC research represents an outpost in that desert.<\/span><\/p>\n

\u201cDr. Wolfenden established physical properties of the twenty amino acids, and we have found a link between those properties and the genetic code,\u201d Carter said. \u201cThat link suggests to us that there was a second, earlier code that made possible the peptide-RNA interactions necessary to launch a selection process that we can envision creating the first life on Earth.\u201d Thus, Carter said, RNA did not have to invent itself from the primordial soup. Instead, even before there were cells, it seems more likely that there were interactions between amino acids and nucleotides that led to the co-creation of proteins and RNA.<\/span><\/p>\n

Complexity from simplicity<\/b><\/span><\/p>\n

Proteins must fold in specific ways to function properly. The first PNAS<\/i> paper, led by Wolfenden, shows that both the polarities of the twenty amino acids (how they distribute between water and oil) and their sizes help explain the complex process of protein folding \u2013 when a chain of connected amino acids arranges itself to form a particular 3-dimensional structure that has a specific biological function.<\/span><\/p>\n

\u201cOur experiments show how the polarities of amino acids change consistently across a wide range of temperatures in ways that would not disrupt the basic relationships between genetic coding and protein folding,\u201d said Wolfenden, Alumni Distinguished Professor of Biochemistry and Biophysics. This was important to establish because when life was first forming on Earth, temperatures were hot, probably much hotter than they are now or when the first plants and animals were established.<\/span><\/p>\n

A series of biochemical experiments with amino acids conducted in Wolfenden\u2019s lab showed that two properties \u2013 the sizes as well as the polarities of amino acids \u2013 were necessary and sufficient to explain how the amino acids behaved in folded proteins and that these relationships also held at the higher temperatures of Earth 4 billion years ago.<\/span><\/p>\n

The second PNAS<\/i> paper, led by Carter, delves into how enzymes called aminoacyl-tRNA synthetases recognized transfer ribonucleic acid, or tRNA. Those enzymes translate the genetic code. \u201cThink of tRNA as an adapter,\u201d Carter said. \u201cOne end of the adapter carries a particular amino acid; the other end reads the genetic blueprint for that amino acid in messenger RNA. Each synthetase matches one of the twenty amino acids with its own adapter so that the genetic blueprint in messenger RNA faithfully makes the correct protein every time.\u201d Carter\u2019s analysis shows that the two different ends of the L-shaped tRNA molecule contained independent codes or rules that specify which amino acid to select. The end of tRNA that carried the amino acid sorted amino acids specifically according to size. The other end of the L-shaped tRNA molecule is called the tRNA anticodon. It reads codons, which are sequences of three RNA nucleotides in genetic messages that select amino acids according to polarity.<\/span><\/p>\n

Wolfenden and Carter\u2019s findings imply that the relationships between tRNA and the physical properties of the amino acids \u2013 their sizes and polarities \u2013 were crucial during the Earth\u2019s primordial era. In light of Carter\u2019s previous work with very small active cores of tRNA synthetases called Urzymes, it now seems likely that selection by size preceded selection according to polarity. This ordered selection meant that the earliest proteins did not necessarily fold into unique shapes, and that their unique structures evolved later.<\/span><\/p>\n

Carter said, \u201cTranslating the genetic code is the nexus connecting pre-biotic chemistry to biology.\u201d He and Wolfenden believe that the intermediate stage of genetic coding can help resolve two paradoxes: how complexity arose from simplicity, and how life divided the labor between two very different kinds of polymers: proteins and nucleic acids. \u201cThe fact that genetic coding developed in two successive stages \u2013 the first of which was relatively simple \u2013 may be one reason why life was able to emerge while the earth was still quite young,\u201d Wolfenden noted.<\/span><\/p>\n

An earlier code, which enabled the earliest coded peptides to bind RNA, may have furnished a decisive selective advantage. And this primitive system could then undergo a natural selection process, thereby launching a new and more biological form of evolution. \u201cThe collaboration between RNA and peptides was likely necessary for the spontaneous emergence of complexity,\u201d Carter added. \u201cIn our view, it was a peptide-RNA world, not an RNA-only world.\u201d<\/span><\/p>\n

The National Institutes of Health funded this work. Dr. Wolfenden holds a joint appointment in the department of chemistry in the College of Arts and Sciences at UNC-Chapel Hill.<\/i><\/span><\/p>\n

Story courtesy of: Mark Derewicz, 919-923-0959, mark.derewicz@unchealth.unc.edu<\/a><\/span><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

University of North Carolina researchers provide evidence for how the genetic code developed in two distinct stages to help primordial chemicals evolve into cells.<\/p>\n","protected":false},"author":12066,"featured_media":4329,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,29,3,49,4],"class_list":["post-4328","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2015","tag-news_dept","tag-news_slider","tag-recent-news","odd"],"acf":[],"yoast_head":"\nNew evidence emerges on the origins of life on Earth | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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