{"id":4373,"date":"2018-02-13T14:55:00","date_gmt":"2018-02-13T19:55:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/"},"modified":"2018-08-01T10:37:20","modified_gmt":"2018-08-01T14:37:20","slug":"researchers-define-structure-function-of-enzyme-key-to-blood-cancers","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/","title":{"rendered":"Researchers define structure, function of enzyme key to blood cancers"},"content":{"rendered":"<div>\n<p class=\"lead\">In the journal Nature, Greg Wang, PhD, assistant professor of Biochemistry and Biophysics and Cell biology Program, and colleagues reported findings about the structure and function of the DNMT3A enzyme complex, which helps control gene expression.<\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\">\n    <img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-4374\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2-300x200.jpeg\" width=\"300\" height=\"200\" alt=\"image2\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2-300x200.jpeg 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2-150x100.jpeg 150w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg 400w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"caption wp-caption-text\">Greg Wang PhD<br \/>\n    <\/figcaption><\/figure>\n<figure class=\"thumbnail wp-caption alignright\">\n    <img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-4375\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image3-205x300.jpeg\" width=\"300\" height=\"200\" alt=\"image3\"\/><figcaption class=\"caption wp-caption-text\">Credit: G. Wang, Nature. (Top) Patterns of chemical tags in DNA change due to a mutation of a DNA-binding amino acid of DNMT3A. Cells with normal and mutated DNMT3A are shown. (Bottom) Cancer cells acquire mutations (in blue) at the DNMT3A binding site.<br \/>\n    <\/figcaption><\/figure>\n<\/div>\n<div>\n<p>Scientists at the University of North Carolina and University of California, Riverside, have unveiled new findings about the structure and function of an enzyme that is commonly mutated in blood disorders and cancers, including acute myeloid leukemia.  <\/p>\n<p style=\"text-align: justify; \">In the journal Nature, the researchers <a class=\"external-link\" href=\"https:\/\/www.nature.com\/articles\/nature25477\" target=\"_self\" title=\"\">reported findings<\/a> about the structure and function of the DNMT3A enzyme complex, which helps control gene expression by organizing DNA. The researchers at the University of California, Riverside, described the structure of DNMT3A, and researchers at UNC Lineberger took the lead on research into how mutations impact the enzyme\u2019s function in the cell. They identified how this enzyme places a type of \u201cchemical tag\u201d at specific DNA sequences, and how mutations in the enzyme can lead to a change in the development course for the cell, as seen in cancer and developmental disorders.<\/p>\n<p style=\"text-align: justify; \">\u201cNow, because we understand the structure of this enzyme and its interaction with DNA, we see where exactly the cancer-related mutations often occur,\u201d said <a class=\"external-link\" href=\"http:\/\/www.med.unc.edu\/biochem\/people\/faculty\/primary\/wang\" target=\"_self\" title=\"Greg Wang profile on UNC Biochemistry site\">Greg Wang, PhD<\/a>, an assistant professor in the UNC School of Medicine Department of Biochemistry &amp; Biophysics and Cell biology Program. \u201cFollowing this lead, we conducted functional studies to show that when the enzyme has a mutation that affects the enzyme\u2019s ability to bind with the DNA, it changes patterns of chemical \u2018tags\u2019 in DNA, affecting the future fate of the cell\u2019s development, and sometimes, leading to cancer.\u201d<\/p>\n<p style=\"text-align: justify; \">UNC researchers studied a class of so-called DNA-binding-defective mutations of DNMT3A detected in human blood cancers, and found that when they put a mutant enzyme into a leukemia cell line, it caused a cancerous phenotype.<\/p>\n<p style=\"text-align: justify; \">The findings improve upon our current understanding of this enzyme in disease development. Previously, the same group of UNC researchers <a class=\"external-link\" href=\"https:\/\/unclineberger.org\/news\/faulty-instructions\" target=\"_self\" title=\"\">showed in a study <\/a>published in the journal Cancer Cell in 2016 that a specific mutation in the DNMT3A gene interferes with the protein-to-protein interaction interface of the enzyme complex, contributing to progression of blood cancer. <\/p>\n<p style=\"text-align: justify; \">\u201cIn this current study, we show cancer cells also often gain somatic mutations to change the interaction of this enzyme, DNMT3A, with DNA in order to perturb DNA methylation and gene expression programs,\u201d Wang said.<\/p>\n<p style=\"text-align: justify; \">Normally, DNMT3A helps to maintain the patterns of \u201cchemical tags\u201d in the DNA to keep certain genes in check. UNC Lineberger researchers have now unveiled the two distinct mechanisms (Cancer Cell 2016 July; Nature 2018 Feb) by which somatic mutations of DNMT3A cause gene regulation defects leading to development of disease, notably blood cancer.<\/p>\n<p style=\"text-align: justify; \"><i>The research was supported by Kimmel Scholar Awards, the March of Dimes Foundation, the U.S. Department of Defense Cancer Research Program, Gabrielle\u2019s Angel Foundation to Cancer Research, Gilead Sciences Research Scholars Program, the University Cancer Research Fund, and the National Institutes of Health.<\/i><\/p>\n<p style=\"text-align: justify; \"><i>The other authors were Zhi-Min Zhang, Rui Lu, Pengcheng Wang, Yang Yu, Dongliang Chen, Linfeng Gao, Shuo Liu, Debin Ji, Scott B. Rothbart, Yinsheng Wang, and Jikui Song.<\/i><\/p>\n<hr\/>\n<p style=\"text-align: left; \"><span class=\"discreet\"><em><span style=\"color: rgb(128, 128, 128); \">Story courtesy of Laura Oleniacz, Science Communications Manager UNC Lineberger<br \/>BCBP Media contact: Carolyn M. Clabo, 919-962-7642, carolyn_clabo@med.unc.edu<\/span><\/em><\/span><\/p>\n<p style=\"text-align: left; \">\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>In the journal Nature, Greg Wang, PhD, assistant professor of Biochemistry and Biophysics and Cell biology Program, and colleagues reported findings about the structure and function of the DNMT3A enzyme complex, which helps control gene expression.<\/p>\n","protected":false},"author":41619,"featured_media":4374,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[38,39,45,10,36,3,37,4,60],"class_list":["post-4373","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-2018-faculty-year-in-review","tag-2018-year-in-review","tag-faculty","tag-news_faculty","tag-news_2018","tag-news_dept","tag-news_faculty_s18","tag-recent-news","tag-wang_news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Researchers define structure, function of enzyme key to blood cancers | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers define structure, function of enzyme key to blood cancers | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"In the journal Nature, Greg Wang, PhD, assistant professor of Biochemistry and Biophysics and Cell biology Program, and colleagues reported findings about the structure and function of the DNMT3A enzyme complex, which helps control gene expression.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-02-13T19:55:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-08-01T14:37:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"266\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"Researchers define structure, function of enzyme key to blood cancers\",\"datePublished\":\"2018-02-13T19:55:00+00:00\",\"dateModified\":\"2018-08-01T14:37:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/\"},\"wordCount\":606,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg\",\"keywords\":[\"2018-faculty-year-in-review\",\"2018-Year-in-Review\",\"Faculty\",\"Faculty &amp; Lab News\",\"News 2018\",\"news_dept\",\"News_Faculty_S18\",\"recent news\",\"Wang_News\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/\",\"name\":\"Researchers define structure, function of enzyme key to blood cancers | Biochemistry and Biophysics\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg\",\"datePublished\":\"2018-02-13T19:55:00+00:00\",\"dateModified\":\"2018-08-01T14:37:20+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg\",\"width\":400,\"height\":266,\"caption\":\"G. Greg Wang PhD, Associate Professor of Biochemistry and Biophysics\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/biochem\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Researchers define structure, function of enzyme key to blood cancers\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"name\":\"UNC Biochemistry and Biophysics\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\",\"name\":\"UNC Department of Biochemistry and Biophysics\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"width\":488,\"height\":400,\"caption\":\"UNC Department of Biochemistry and Biophysics\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\",\"https:\/\/x.com\/UNC_BCBP\",\"https:\/\/www.instagram.com\/unc_bcbp\/\",\"https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\",\"name\":\"Carolyn Clabo\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"caption\":\"Carolyn Clabo\"},\"description\":\"Biochemistry &amp; Biophysics - Communications &amp; Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology &amp; Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement &amp; Univ. Development (former)\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Researchers define structure, function of enzyme key to blood cancers | Biochemistry and Biophysics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/","og_locale":"en_US","og_type":"article","og_title":"Researchers define structure, function of enzyme key to blood cancers | Biochemistry and Biophysics","og_description":"In the journal Nature, Greg Wang, PhD, assistant professor of Biochemistry and Biophysics and Cell biology Program, and colleagues reported findings about the structure and function of the DNMT3A enzyme complex, which helps control gene expression.","og_url":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/","og_site_name":"Biochemistry and Biophysics","article_publisher":"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","article_published_time":"2018-02-13T19:55:00+00:00","article_modified_time":"2018-08-01T14:37:20+00:00","og_image":[{"width":400,"height":266,"url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg","type":"image\/jpeg"}],"author":"Carolyn Clabo","twitter_card":"summary_large_image","twitter_creator":"@UNC_BCBP","twitter_site":"@UNC_BCBP","twitter_misc":{"Written by":"Carolyn Clabo","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/"},"author":{"name":"Carolyn Clabo","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332"},"headline":"Researchers define structure, function of enzyme key to blood cancers","datePublished":"2018-02-13T19:55:00+00:00","dateModified":"2018-08-01T14:37:20+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/"},"wordCount":606,"publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg","keywords":["2018-faculty-year-in-review","2018-Year-in-Review","Faculty","Faculty &amp; Lab News","News 2018","news_dept","News_Faculty_S18","recent news","Wang_News"],"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/","url":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/","name":"Researchers define structure, function of enzyme key to blood cancers | Biochemistry and Biophysics","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg","datePublished":"2018-02-13T19:55:00+00:00","dateModified":"2018-08-01T14:37:20+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#primaryimage","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg","width":400,"height":266,"caption":"G. Greg Wang PhD, Associate Professor of Biochemistry and Biophysics"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/biochem\/"},{"@type":"ListItem","position":2,"name":"Researchers define structure, function of enzyme key to blood cancers"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/biochem\/#website","url":"https:\/\/www.med.unc.edu\/biochem\/","name":"UNC Biochemistry and Biophysics","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/biochem\/#organization","name":"UNC Department of Biochemistry and Biophysics","url":"https:\/\/www.med.unc.edu\/biochem\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","width":488,"height":400,"caption":"UNC Department of Biochemistry and Biophysics"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","https:\/\/x.com\/UNC_BCBP","https:\/\/www.instagram.com\/unc_bcbp\/","https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/"]},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332","name":"Carolyn Clabo","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","caption":"Carolyn Clabo"},"description":"Biochemistry &amp; Biophysics - Communications &amp; Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology &amp; Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement &amp; Univ. Development (former)","url":"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg","featured_image_medium":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2-300x200.jpeg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg","featured_image_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2.jpeg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/researchers-define-structure-function-of-enzyme-key-to-blood-cancers-image2-150x100.jpeg","featured_image_alt":"Greg Wang PhD","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/biochem\/category\/news\/"}],"tag_details":[{"name":"2018-faculty-year-in-review","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/2018-faculty-year-in-review\/"},{"name":"2018-Year-in-Review","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/2018-year-in-review\/"},{"name":"Faculty","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/faculty\/"},{"name":"Faculty &amp; Lab News","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_faculty\/"},{"name":"News 2018","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_2018\/"},{"name":"news_dept","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_dept\/"},{"name":"News_Faculty_S18","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_faculty_s18\/"},{"name":"recent news","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/recent-news\/"},{"name":"Wang_News","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/wang_news\/"}],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/4373","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/users\/41619"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/comments?post=4373"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/4373\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media\/4374"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media?parent=4373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/categories?post=4373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/tags?post=4373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}