{"id":4487,"date":"2017-03-07T19:20:00","date_gmt":"2017-03-08T00:20:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/"},"modified":"2018-08-01T10:41:03","modified_gmt":"2018-08-01T14:41:03","slug":"unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/","title":{"rendered":"UNC research helps answer why genetic mutation leads to decreased triglycerides in blood"},"content":{"rendered":"<div>\n<p class=\"lead\">Cassandra Hayne, working with Saskia Neher, PhD, found that a specific mutated version of a lipoprotein binds more effectively to liver cells, thus explaining decreased levels of triglycerides in blood.<\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\">\n    <img loading=\"lazy\" decoding=\"async\" class=\"size-medium size-full wp-image-4488\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg\" width=\"300\" height=\"200\" alt=\"image2\"\/><figcaption class=\"caption wp-caption-text\">Cassandra Hayne<br \/>\n    <\/figcaption><\/figure>\n<figure class=\"thumbnail wp-caption alignright\">\n    <img loading=\"lazy\" decoding=\"async\" class=\"size-medium size-full wp-image-4489\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image3.jpeg\" width=\"300\" height=\"200\" alt=\"image3\"\/><figcaption class=\"caption wp-caption-text\">Saskia Neher, PhD<br \/>\n    <\/figcaption><\/figure>\n<\/div>\n<div>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \">Common knowledge says that genetic mutations are bad. This is true for most mutations of lipoprotein lipase (LPL), the enzyme in the blood responsible for the breakdown of lipoproteins, which allows tissue to utilize energy from fat. People with these mutations are unable to break down fat in the blood, causing very high levels of lipids in the blood and putting them at risk of heart disease. However, one specific mutation actually leads to better processing of lipids, leading to improved heart health.<\/p>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \">This mutation was first discovered in the early 1990s, and since then scientists have understood the mutation\u2019s positive result. It\u2019s even used in a gene therapy treatment approved in Europe.  But even though the result of the mutation was understood, the mechanism that caused it was not.<\/p>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \">\u201cMutations most commonly result in loss of function,\u201d said Saskia Neher, PhD, assistant professor of biochemistry and biophysics at the UNC School of Medicine. \u201cIn this case, there\u2019s a mutation and the function is actually better. We wanted to know why.\u201d<\/p>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \">Research published in the journal<span class=\"Apple-converted-space\"> <\/span><i style=\"margin: 0px; padding: 0px; \">Biochemistry<span class=\"Apple-converted-space\"> <\/span><\/i>this month helps to finally answer the question. The first author on the study is Cassandra Hayne, a doctoral candidate in UNC\u2019s department of biochemistry and biophysics. The discovery comes as the result of great persistence on Hayne\u2019s part.<\/p>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \">Hayne and Neher used highly purified LPL and the truncated protein, LPL-S447X, to compare the ability of each to breakdown lipoproteins. They found no difference in the proteins\u2019 ability to process lipoproteins.<\/p>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \">\u201cWhen we didn\u2019t find a clear answer, I had to begin thinking about secondary functions of LPL,\u201d Hayne said. \u201cI knew that one of those secondary functions was that LPL serves as a bridge to three different cell receptors in the liver.\u201d<\/p>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \">Hayne found that the increased function of LPL-S447X can be attributed to the fact that it more effectively binds to the receptors in the liver, leading to increased uptake of lipoproteins in the liver. The increased liver function explained what is seen in patients\u2019 blood: a decrease in triglycerides.<\/p>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \">\u201cThis finding is really a testament to Cassandra\u2019s persistence,\u201d said Neher, also a member of the McAllister Heart Institute. \u201cWe kept trying this and that, thinking we\u2019d find something different. LPL-S447X has been studied for years without a satisfying answer. I feel like we have that now.\u201d<\/p>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \"><i style=\"margin: 0px; padding: 0px; \">The research was funded by the National Institute of Health<\/i><\/p>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \">\n<hr\/>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \"><i style=\"margin: 0px; padding: 0px; \">Story courtesy of Jamie Williams,<span class=\"Apple-converted-space\"> <\/span><a href=\"mailto:jamie.williams@unchealth.unc.edu\" style=\"margin: 0px; padding: 0px; color: rgb(153, 65, 0); text-decoration: none; border-bottom: 1px dotted; \">jamie.williams@unchealth.unc.edu<\/a>, 984-974-1149<\/i><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>Cassandra Hayne, working with Saskia Neher, PhD, found that a specific mutated version of a lipoprotein binds more effectively to liver cells, thus explaining decreased levels of triglycerides in blood.<\/p>\n","protected":false},"author":41619,"featured_media":4488,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[32,30,10,28,3,31,4,13],"class_list":["post-4487","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-2017_student_year_in-review","tag-2017-year-in-review","tag-news_faculty","tag-news_2017","tag-news_dept","tag-news_studentpostdocstaff_s17","tag-recent-news","tag-news_students","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNC research helps answer why genetic mutation leads to decreased triglycerides in blood | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UNC research helps answer why genetic mutation leads to decreased triglycerides in blood | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Cassandra Hayne, working with Saskia Neher, PhD, found that a specific mutated version of a lipoprotein binds more effectively to liver cells, thus explaining decreased levels of triglycerides in blood.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-03-08T00:20:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-08-01T14:41:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"200\" \/>\n\t<meta property=\"og:image:height\" content=\"200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"UNC research helps answer why genetic mutation leads to decreased triglycerides in blood\",\"datePublished\":\"2017-03-08T00:20:00+00:00\",\"dateModified\":\"2018-08-01T14:41:03+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/\"},\"wordCount\":467,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg\",\"keywords\":[\"2017_student_year_in review\",\"2017-Year-in-Review\",\"Faculty &amp; Lab News\",\"News 2017\",\"news_dept\",\"News_StudentPostdocStaff_S17\",\"recent news\",\"Student News\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/\",\"name\":\"UNC research helps answer why genetic mutation leads to decreased triglycerides in blood | Biochemistry and Biophysics\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg\",\"datePublished\":\"2017-03-08T00:20:00+00:00\",\"dateModified\":\"2018-08-01T14:41:03+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg\",\"width\":200,\"height\":200,\"caption\":\"Cassandra Hayne\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/biochem\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"UNC research helps answer why genetic mutation leads to decreased triglycerides in blood\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"name\":\"UNC Biochemistry and Biophysics\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\",\"name\":\"UNC Department of Biochemistry and Biophysics\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"width\":488,\"height\":400,\"caption\":\"UNC Department of Biochemistry and Biophysics\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\",\"https:\/\/x.com\/UNC_BCBP\",\"https:\/\/www.instagram.com\/unc_bcbp\/\",\"https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\",\"name\":\"Carolyn Clabo\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"caption\":\"Carolyn Clabo\"},\"description\":\"Biochemistry &amp; Biophysics - Communications &amp; Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology &amp; Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement &amp; Univ. Development (former)\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"UNC research helps answer why genetic mutation leads to decreased triglycerides in blood | Biochemistry and Biophysics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/","og_locale":"en_US","og_type":"article","og_title":"UNC research helps answer why genetic mutation leads to decreased triglycerides in blood | Biochemistry and Biophysics","og_description":"Cassandra Hayne, working with Saskia Neher, PhD, found that a specific mutated version of a lipoprotein binds more effectively to liver cells, thus explaining decreased levels of triglycerides in blood.","og_url":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/","og_site_name":"Biochemistry and Biophysics","article_publisher":"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","article_published_time":"2017-03-08T00:20:00+00:00","article_modified_time":"2018-08-01T14:41:03+00:00","og_image":[{"width":200,"height":200,"url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg","type":"image\/jpeg"}],"author":"Carolyn Clabo","twitter_card":"summary_large_image","twitter_creator":"@UNC_BCBP","twitter_site":"@UNC_BCBP","twitter_misc":{"Written by":"Carolyn Clabo","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/"},"author":{"name":"Carolyn Clabo","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332"},"headline":"UNC research helps answer why genetic mutation leads to decreased triglycerides in blood","datePublished":"2017-03-08T00:20:00+00:00","dateModified":"2018-08-01T14:41:03+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/"},"wordCount":467,"publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg","keywords":["2017_student_year_in review","2017-Year-in-Review","Faculty &amp; Lab News","News 2017","news_dept","News_StudentPostdocStaff_S17","recent news","Student News"],"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/","url":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/","name":"UNC research helps answer why genetic mutation leads to decreased triglycerides in blood | Biochemistry and Biophysics","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg","datePublished":"2017-03-08T00:20:00+00:00","dateModified":"2018-08-01T14:41:03+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#primaryimage","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg","width":200,"height":200,"caption":"Cassandra Hayne"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/biochem\/"},{"@type":"ListItem","position":2,"name":"UNC research helps answer why genetic mutation leads to decreased triglycerides in blood"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/biochem\/#website","url":"https:\/\/www.med.unc.edu\/biochem\/","name":"UNC Biochemistry and Biophysics","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/biochem\/#organization","name":"UNC Department of Biochemistry and Biophysics","url":"https:\/\/www.med.unc.edu\/biochem\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","width":488,"height":400,"caption":"UNC Department of Biochemistry and Biophysics"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","https:\/\/x.com\/UNC_BCBP","https:\/\/www.instagram.com\/unc_bcbp\/","https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/"]},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332","name":"Carolyn Clabo","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","caption":"Carolyn Clabo"},"description":"Biochemistry &amp; Biophysics - Communications &amp; Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology &amp; Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement &amp; Univ. Development (former)","url":"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg","featured_image_medium":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg","featured_image_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2.jpeg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-research-helps-answer-why-genetic-mutation-leads-to-decreased-triglycerides-in-blood-image2-150x150.jpeg","featured_image_alt":"Cassandra Hayne","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/biochem\/category\/news\/"}],"tag_details":[{"name":"2017_student_year_in review","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/2017_student_year_in-review\/"},{"name":"2017-Year-in-Review","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/2017-year-in-review\/"},{"name":"Faculty &amp; Lab News","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_faculty\/"},{"name":"News 2017","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_2017\/"},{"name":"news_dept","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_dept\/"},{"name":"News_StudentPostdocStaff_S17","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_studentpostdocstaff_s17\/"},{"name":"recent news","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/recent-news\/"},{"name":"Student News","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_students\/"}],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/4487","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/users\/41619"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/comments?post=4487"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/4487\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media\/4488"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media?parent=4487"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/categories?post=4487"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/tags?post=4487"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}