{"id":4490,"date":"2014-09-18T17:13:42","date_gmt":"2014-09-18T21:13:42","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/unc-researchers-autism\/"},"modified":"2018-08-01T10:41:07","modified_gmt":"2018-08-01T14:41:07","slug":"unc-researchers-autism","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/","title":{"rendered":"UNC researchers link gene to increased dendritic spines \u2013 a signpost of autism"},"content":{"rendered":"
\n

By deleting the NrCAM gene, scientists have found a potential way to cut back on the neural connections implicated in Autism Spectrum Disorder.<\/p>\n

\n
\n \"image2\"\/
Patricia Maness, PhD
\n <\/figcaption><\/figure>\n
\n \"image3\"\/
A comparison of a dendrite with the protein NrCAM (top) and a dendrite without the protein (bottom), which has a greater density of spines that neurons use to form synaptic connections.
\n <\/figcaption><\/figure>\n<\/div>\n
\n

Scientists at the UNC School of Medicine have discovered that knocking out the gene NrCAM leads to an increase of dendritic spines on excitatory pyramidal cells in the brains of mammals. Other studies have confirmed that the overabundance of dendritic spines on this type of brain cell allows for too many synaptic connections to form between neurons \u2013 a phenomenon strongly linked to autism.<\/p>\n

The finding, published in <\/span>The Journal of<\/i> <\/span>Neuroscience<\/i>, adds evidence that NrCAM is a major player in neurological disorders. Previous UNC studies showed that knocking out the NrCAM gene caused mice to exhibit the same sorts of social behaviors associated with autism in humans.<\/p>\n

\u201cThere are many genes involved in autism, but we\u2019re now finding out exactly which ones and how they\u2019re involved,\u201d said Patricia Maness, PhD, professor of biochemistry and biophysics and senior author of the <\/span>Journal of Neuroscience<\/i> <\/span>paper. \u201cKnowing that NrCAM has this effect on dendrites allows us to test potential drugs, not only to observe a change in behaviors linked to autism but to see if we can improve dendritic spine abnormalities, which may underlie autism.<\/p>\n

Maness\u2019s finding comes on the heels of <\/span>a report from Columbia University<\/a>researchers who found an overabundance of the protein MTOR in mice bred to develop a rare form of autism. By using a drug to limit MTOR in mice, the Columbia researchers were able to decrease the number of dendritic spines and thus prune the overabundance of synaptic connections during adolescence. As a result, the social behaviors associated with autism were decreased. However, the drug used to limit MTOR can cause serious side effects, and it is located inside cells, making it a potentially difficult protein to target.<\/p>\n

It is too early to tell if NrCAM and MTOR are linked, but Maness is now studying if the decreased amount of the NrCAM protein could trigger activation of MTOR. If so, then NrCAM, which is an accessible membrane-bound protein, might be a preferred therapeutic target for certain autism-related conditions.<\/p>\n

In their study, Maness and her colleagues found that the NrCAM protein forms a complex with two other molecules to create a receptor on the membrane of excitatory pyramidal neurons. Maness\u2019s team found that this receptor allows dendritic spines to retract, allowing for proper neuron pruning during maturation of the cortex. As a result, excitatory and inhibitory synapses between neurons develop in a balanced ratio necessary for brain circuits to function properly. <\/p>\n

Maness, a member of the UNC Neuroscience Center and the Carolina Institute for Developmental Disabilities, also said that there are likely many other proteins downstream of NrCAM that depend on the protein to maintain the proper amount of dendritic spines. Decreasing NrCAM could allow for an increase in the levels of some of these proteins, thus kick starting the creation of dendritic spines.<\/p>\n

\u201cBasic science in autism is converging in really exciting ways,\u201d Maness said. \u201cToo many spines and too many excitatory connections that are not pruned between early childhood and adolescence <\/span>could be<\/i> <\/span>one of the chief problems underlying autism. Our goal is to understand the molecular mechanisms involved in pruning and find promising targets for therapeutic agents.\u201d<\/p>\n

This research was funded by the National Institutes of Health and a Charles and Johanna Busch Biomedical Award.<\/i><\/p>\n

First authors of the <\/span><\/i>Journal of Neuroscience <\/span>paper are Vishwa Mohan, PhD, a UNC postdoctoral research associate, and Galina Demyanenko, PhD, a former research professor at UNC now retired. Other authors include Xuying Zhang, PhD, a UNC postdoctoral fellow; Leann Brennaman, PhD, a former research associate in the Maness lab; Paul Manis, PhD, Professor of otolaryngology\/head and neck surgery in the UNC School of Medicine; undergraduate student Katherine Dharbal, and Tracy Tran, PhD, assistant professor of biological sciences at Rutgers University.<\/i><\/p>\n

Written by Mark Derewicz, 919-923-0959,<\/span>mark.derewicz@unchealth.unc.edu<\/a><\/i><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

By deleting the NrCAM gene, scientists have found a potential way to cut back on the neural connections implicated in Autism Spectrum Disorder.<\/p>\n","protected":false},"author":37803,"featured_media":4491,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,20,4],"class_list":["post-4490","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2014","tag-recent-news","odd"],"acf":[],"yoast_head":"\nUNC researchers link gene to increased dendritic spines \u2013 a signpost of autism | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UNC researchers link gene to increased dendritic spines \u2013 a signpost of autism | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"By deleting the NrCAM gene, scientists have found a potential way to cut back on the neural connections implicated in Autism Spectrum Disorder.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2014-09-18T21:13:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-08-01T14:41:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"300\" \/>\n\t<meta property=\"og:image:height\" content=\"323\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"UNC researchers link gene to increased dendritic spines \u2013 a signpost of autism\",\"datePublished\":\"2014-09-18T21:13:42+00:00\",\"dateModified\":\"2018-08-01T14:41:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/\"},\"wordCount\":706,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg\",\"keywords\":[\"Faculty & Lab News\",\"News_2014\",\"recent news\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/\",\"name\":\"UNC researchers link gene to increased dendritic spines \u2013 a signpost of autism | Biochemistry and Biophysics\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg\",\"datePublished\":\"2014-09-18T21:13:42+00:00\",\"dateModified\":\"2018-08-01T14:41:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg\",\"width\":300,\"height\":323,\"caption\":\"Patricia Maness, PhD\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/biochem\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"UNC researchers link gene to increased dendritic spines \u2013 a signpost of autism\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"name\":\"UNC Biochemistry and Biophysics\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\",\"name\":\"UNC Department of Biochemistry and Biophysics\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"width\":488,\"height\":400,\"caption\":\"UNC Department of Biochemistry and Biophysics\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\",\"https:\/\/x.com\/UNC_BCBP\",\"https:\/\/www.instagram.com\/unc_bcbp\/\",\"https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/\"]},{\"@type\":\"Person\",\"@id\":\"\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/author\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"UNC researchers link gene to increased dendritic spines \u2013 a signpost of autism | Biochemistry and Biophysics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/","og_locale":"en_US","og_type":"article","og_title":"UNC researchers link gene to increased dendritic spines \u2013 a signpost of autism | Biochemistry and Biophysics","og_description":"By deleting the NrCAM gene, scientists have found a potential way to cut back on the neural connections implicated in Autism Spectrum Disorder.","og_url":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/","og_site_name":"Biochemistry and Biophysics","article_publisher":"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","article_published_time":"2014-09-18T21:13:42+00:00","article_modified_time":"2018-08-01T14:41:07+00:00","og_image":[{"width":300,"height":323,"url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_creator":"@UNC_BCBP","twitter_site":"@UNC_BCBP","twitter_misc":{"Written by":"","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/"},"author":{"name":"","@id":""},"headline":"UNC researchers link gene to increased dendritic spines \u2013 a signpost of autism","datePublished":"2014-09-18T21:13:42+00:00","dateModified":"2018-08-01T14:41:07+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/"},"wordCount":706,"publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg","keywords":["Faculty & Lab News","News_2014","recent news"],"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/","url":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/","name":"UNC researchers link gene to increased dendritic spines \u2013 a signpost of autism | Biochemistry and Biophysics","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg","datePublished":"2014-09-18T21:13:42+00:00","dateModified":"2018-08-01T14:41:07+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#primaryimage","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg","width":300,"height":323,"caption":"Patricia Maness, PhD"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-autism\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/biochem\/"},{"@type":"ListItem","position":2,"name":"UNC researchers link gene to increased dendritic spines \u2013 a signpost of autism"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/biochem\/#website","url":"https:\/\/www.med.unc.edu\/biochem\/","name":"UNC Biochemistry and Biophysics","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/biochem\/#organization","name":"UNC Department of Biochemistry and Biophysics","url":"https:\/\/www.med.unc.edu\/biochem\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","width":488,"height":400,"caption":"UNC Department of Biochemistry and Biophysics"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","https:\/\/x.com\/UNC_BCBP","https:\/\/www.instagram.com\/unc_bcbp\/","https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/"]},{"@type":"Person","@id":"","url":"https:\/\/www.med.unc.edu\/biochem\/author\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg","featured_image_medium":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2-279x300.jpeg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg","featured_image_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2.jpeg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-autism-image2-150x162.jpeg","featured_image_alt":"Patricia Maness, PhD","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/biochem\/category\/news\/"}],"tag_details":[{"name":"Faculty & Lab News","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_faculty\/"},{"name":"News_2014","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_2014\/"},{"name":"recent news","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/recent-news\/"}],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/4490","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/users\/37803"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/comments?post=4490"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/4490\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media\/4491"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media?parent=4490"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/categories?post=4490"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/tags?post=4490"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}