{"id":4495,"date":"2015-07-21T16:50:00","date_gmt":"2015-07-21T20:50:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/unc-researchers-earn-prestigious-keck-award-for-cell-cycle-map\/"},"modified":"2018-08-01T10:41:15","modified_gmt":"2018-08-01T14:41:15","slug":"unc-researchers-earn-prestigious-keck-award-for-cell-cycle-map","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-researchers-earn-prestigious-keck-award-for-cell-cycle-map\/","title":{"rendered":"UNC researchers earn prestigious Keck award for cell cycle map"},"content":{"rendered":"<div>\n<p class=\"lead\">The labs of Jean Cook, PhD, and Jeremy Purvis, PhD, will develop the first-ever interactive molecular model of a crucial cellular process that controls healthy growth and diseases such as cancer.<\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\">\n    <img loading=\"lazy\" decoding=\"async\" class=\"size-medium size-full wp-image-4496\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-earn-prestigious-keck-award-for-cell-cycle-map-image2.jpeg\" width=\"300\" height=\"200\" alt=\"image2\"\/><figcaption class=\"caption wp-caption-text\">Jean Cook, PhD<br \/>\n    <\/figcaption><\/figure>\n<figure class=\"thumbnail wp-caption alignright\">\n    <img loading=\"lazy\" decoding=\"async\" class=\"size-medium size-full wp-image-4497\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-researchers-earn-prestigious-keck-award-for-cell-cycle-map-image3.jpeg\" width=\"300\" height=\"200\" alt=\"image3\"\/><figcaption class=\"caption wp-caption-text\">Jeremy Purvis, PhD<br \/>\n    <\/figcaption><\/figure>\n<\/div>\n<div>\n<p><span style=\"color: rgb(51, 51, 51); \">July 16, 2015<\/span><\/p>\n<p><span style=\"color: rgb(51, 51, 51); \">Two labs at the UNC School of Medicine earned a four-year, $1.3-million grant from the W.M. Keck Foundation to build a \u201creal-time map\u201d of the events in the human cell cycle that are important for normal cell proliferation and development, as well as during diseases such as cancer.<\/span><\/p>\n<p><span style=\"color: rgb(51, 51, 51); \">The labs of <a class=\"external-link\" href=\"https:\/\/sites.google.com\/site\/cooklabgroup\/home\" target=\"_blank\" title=\"\">Jean Cook, PhD<\/a>, associate professor of biochemistry and biophysics, and <a class=\"external-link\" href=\"http:\/\/www.med.unc.edu\/genetics\/purvislab\" target=\"_blank\" title=\"\">Jeremy Purvis, PhD<\/a>, assistant professor of genetics, will use live-cell fluorescence imaging to build the interactive map of the complicated molecular interactions that trigger and carry out DNA replication and chromosome separation \u2013 both key steps that lead to a single cell dividing into two. Such a map will allow the scientists to compare the cycles of different cell types, such as adult and embryonic cells. <\/span><\/p>\n<p><span style=\"color: rgb(51, 51, 51); \">The goal is to produce the first comprehensive, interactive cell cycle model that will be publically available so scientists can explore new relationships between cell cycle events, create hypotheses, and test treatments that target specific parts of the cell cycle.<\/span><\/p>\n<p><span style=\"color: rgb(51, 51, 51); \">\u201cWe know that the cell cycle involves a complex sequence of molecular events, but our current knowledge of it comes largely from snapshot measurements that can\u2019t show us the underlying dynamics of those events, such as when exactly they happen in relation to each other,\u201d said Cook, who holds a joint appointment in the department of pharmacology. \u201cWe plan to use an interdisciplinary approach to assemble the first real-time map of the cycle so that we and other researchers can better evaluate its importance to normal health and diseases.\u201d<\/span><\/p>\n<p><span style=\"color: rgb(51, 51, 51); \">Over the course of four years, Cook and Purvis, who are both members of the UNC Lineberger Comprehensive Cancer Center, will create and validate a suite of novel fluorescent biosensors that will allow them to visualize the key events throughout the cell cycles of normal epithelial cells, stem cells, and differentiated cells \u2013 which descend from stem cells to form various organs and body parts.<\/span><span style=\"color: rgb(51, 51, 51); \"\/><\/p>\n<p><span style=\"color: rgb(51, 51, 51); \">With these new biosensors, the labs will use time-lapse microscopy and automated image analysis to track transitions within individual cell cycles. For the final step, the research teams will use a new computer algorithm developed in the Purvis lab to assemble the resulting image sequences and link together each of the cell cycle transitions into a continuous molecular timeline.  That timeline will become the basis for a predictive model of the cell cycle that can be used to virtually test the effects of mutations or drugs.<\/span><\/p>\n<p><span style=\"color: rgb(51, 51, 51); \">\u201cThe cell cycle is one of the most basic biological processes, but our understanding of it is lacking because of the way we have been looking at it.\u201d Purvis said. \u201cIt\u2019s like trying to put together a photo album by gathering hundreds of pictures taken by different people from different angles. With this award, we will get the chance to make the first cell cycle movie.\u201d<\/span><\/p>\n<hr\/>\n<p><span style=\"color: rgb(51, 51, 51); \"><i>Jean Cook, PhD, is also the associate dean for graduate education at the UNC School of Medicine and the director of the Biomedical and Biological Sciences Program (<\/i><a href=\"http:\/\/bbsp.unc.edu\/\"><span style=\"color: rgb(51, 51, 51); \"><i>BBSP<\/i><\/span><\/a><i>)<\/i><\/span><\/p>\n<p><span style=\"color: rgb(51, 51, 51); \"><i>The <\/i><a href=\"http:\/\/www.wmkeck.org\/?view=featured\"><span style=\"color: rgb(51, 51, 51); \"><i>W.M. Keck Foundation<\/i><\/span><\/a><\/span><i><span style=\"color: rgb(51, 51, 51); \">, founded in 1954, supports the exploration of discoveries in science, engineering, and medical research<\/span>.<\/i><\/p>\n<p><span style=\"color: rgb(51, 51, 51); \">Media Contact: Mark Derewicz, 919-923-0959,<\/span> <a href=\"mailto:mark.derewicz@unch.unc.edu\">mark.derewicz@unch.unc.edu<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>The labs of Jean Cook, PhD, and Jeremy Purvis, PhD, will develop the first-ever interactive molecular model of a crucial cellular process that controls healthy growth and diseases such as cancer.<\/p>\n","protected":false},"author":12066,"featured_media":4496,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[10,29,3,49,4],"class_list":["post-4495","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news_faculty","tag-news_2015","tag-news_dept","tag-news_slider","tag-recent-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNC researchers earn prestigious Keck award for cell cycle map | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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