{"id":4508,"date":"2017-12-12T19:20:00","date_gmt":"2017-12-13T00:20:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/"},"modified":"2018-08-01T10:41:39","modified_gmt":"2018-08-01T14:41:39","slug":"unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/","title":{"rendered":"UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State"},"content":{"rendered":"<div>\n<p class=\"lead\">The lab of Jean Cook, PhD, in the Department of Biochemistry and Biophysics, found how a chain of proteins called an MCM complex could enable the fast cell-division that makes some forms of cancer so dangerous. The study first author Jacob Matson, a PhD candidate in the Cook lab performed most of the experiments.<\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\">\n    <img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-4509\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2-287x300.jpeg\" width=\"300\" height=\"200\" alt=\"image2\"\/><figcaption class=\"caption wp-caption-text\">Jean Cook, PhD<br \/>\n    <\/figcaption><\/figure>\n<figure class=\"thumbnail wp-caption alignright\">\n    <img loading=\"lazy\" decoding=\"async\" class=\"size-medium size-full wp-image-4510\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image3.jpeg\" width=\"300\" height=\"200\" alt=\"image3\"\/><figcaption class=\"caption wp-caption-text\">Jacob Matson, Graduate Student, Cook lab<br \/>\n    <\/figcaption><\/figure>\n<\/div>\n<div>\n<p>A special cluster of proteins that helps unwind DNA during cell division plays a key role in keeping stem cells in their immature state, according to a new study by UNC School of Medicine researchers.<\/p>\n<p>Published in the online journal <i>eLife,<\/i> this study illuminates the basic biology of stem cells, and suggests a new molecular handle for controlling them. Stem cells have regenerative properties with the potential to revolutionize medicine, but that potential is still far from being realized because too little is known about how these cells work. The study also points to a better understanding of how cancer cells manage to sustain rapid cell division without triggering cell death.<\/p>\n<p> <img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"106\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/cook-research-image-300x106.jpeg\" alt=\"Jean Cook Lab DNA research Jacob Matson eLife Proteins Stem Cells\" class=\"image-inline size-medium wp-image-4511\" title=\"Cook Research Image\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/cook-research-image-300x106.jpeg 300w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/cook-research-image-150x53.jpeg 150w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/cook-research-image-768x271.jpeg 768w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/cook-research-image.jpeg 975w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/><span class=\"discreet\">Red, stem cells. Green, differentiating cells. (Cook lab)<\/span><\/p>\n<p><a class=\"external-link\" href=\"https:\/\/elifesciences.org\/articles\/30473\" target=\"_self\" title=\"\">The study<\/a> focused on a cluster of proteins called the minichromosome maintenance (MCM) complex, known to be a crucial factor in cell division. A cell prepares for the division process in part by loading MCM complexes onto its chromosomes. These complexes are needed to properly unwind chromosomal DNA during cell division so that two new sets of chromosomes \u2013 one for each daughter cell \u2013 can be formed from the original set.<\/p>\n<p>\u201cIf MCM loading isn\u2019t completed successfully prior to cell division, there\u2019ll be a risk of major DNA mutations and death for the resulting daughter cells,\u201d said study first author Jacob Matson, a PhD candidate in the Cook laboratory who performed most of the experiments over the course of three years.<\/p>\n<p><span>The results suggest that MCM loading rate is an important factor in cell development, and that speedy MCM loading in particular is something that stem cells do to maintain themselves in the immature, stem cell state.<\/span><\/p>\n<p>For more information on this study please click on the <a class=\"external-link\" href=\"http:\/\/news.unchealthcare.org\/news\/2017\/december\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state?utm_source=vs-email&amp;utm_medium=email&amp;utm_campaign=50\" target=\"_self\" title=\"\">Vital Signs article<\/a>.<\/p>\n<p><i>The laboratories of Jeremy Purvis, PhD, assistant professor of genetics at UNC, and Anja-Katrin Bielinsky, PhD, of the University of Minnesota, collaborated in the study. Cook has <i>a primary appointment in Biochemistry and Biophysics and <\/i>a joint appointment in the UNC department of pharmacology and is the associate dean for graduate education at the UNC School of Medicine.<\/i><\/p>\n<p><i>Funding was provided by the National Science Foundation, the National Institutes of Health, and the W.M. Keck foundation.<\/i><\/p>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \"><span class=\"discreet\"><i style=\"margin: 0px; padding: 0px; \">Story courtesy of Mark Derewicz,<span class=\"Apple-converted-space\"> <a class=\"email-link\" href=\"mailto:mark.derewicz@unchealth.unc.edu\" target=\"_self\" title=\"\">mark.derewicz@unchealth.unc.edu<\/a><\/span>, 984-974-1915<br \/><\/i><\/span><\/p>\n<hr\/>\n<p><span class=\"discreet\"><em>To submit a news story contact: Carolyn M. Clabo, 919-962-7642, <a class=\"email-link\" href=\"mailto:carolyn_clabo@med.unc.edu\" target=\"_self\" title=\"\">carolyn_clabo@med.unc.edu<\/a> UNC BCBP Communications<\/em><\/span><\/p>\n<p style=\"margin: 0px 0px 1em; padding: 0px; color: rgb(50, 50, 50); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; word-spacing: 0px; text-stroke-width: 0px; background-color: rgb(255, 255, 255); \"><span class=\"discreet\"\/><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>The lab of Jean Cook, PhD, in the Department of Biochemistry and Biophysics, found how a chain of proteins called an MCM complex could enable the fast cell-division that makes some forms of cancer so dangerous. The study first author Jacob Matson, a PhD candidate in the Cook lab performed most of the experiments.<\/p>\n","protected":false},"author":41619,"featured_media":4509,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[63,32,34,30,74,10,28,3,31,4,13],"class_list":["post-4508","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-2017-newsletter","tag-2017_student_year_in-review","tag-2017-faculty-year-in-review","tag-2017-year-in-review","tag-cook","tag-news_faculty","tag-news_2017","tag-news_dept","tag-news_studentpostdocstaff_s17","tag-recent-news","tag-news_students","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"The lab of Jean Cook, PhD, in the Department of Biochemistry and Biophysics, found how a chain of proteins called an MCM complex could enable the fast cell-division that makes some forms of cancer so dangerous. The study first author Jacob Matson, a PhD candidate in the Cook lab performed most of the experiments.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Biophysics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-12-13T00:20:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-08-01T14:41:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"287\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Carolyn Clabo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_BCBP\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carolyn Clabo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/\"},\"author\":{\"name\":\"Carolyn Clabo\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\"},\"headline\":\"UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State\",\"datePublished\":\"2017-12-13T00:20:00+00:00\",\"dateModified\":\"2018-08-01T14:41:39+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/\"},\"wordCount\":472,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg\",\"keywords\":[\"2017 newsletter\",\"2017_student_year_in review\",\"2017-faculty-year-in-review\",\"2017-Year-in-Review\",\"Cook\",\"Faculty &amp; Lab News\",\"News 2017\",\"news_dept\",\"News_StudentPostdocStaff_S17\",\"recent news\",\"Student News\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/\",\"name\":\"UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State | Biochemistry and Biophysics\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg\",\"datePublished\":\"2017-12-13T00:20:00+00:00\",\"dateModified\":\"2018-08-01T14:41:39+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg\",\"width\":287,\"height\":300,\"caption\":\"Jean Cook, PhD\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/biochem\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"name\":\"UNC Biochemistry and Biophysics\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#organization\",\"name\":\"UNC Department of Biochemistry and Biophysics\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png\",\"width\":488,\"height\":400,\"caption\":\"UNC Department of Biochemistry and Biophysics\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/\",\"https:\/\/x.com\/UNC_BCBP\",\"https:\/\/www.instagram.com\/unc_bcbp\/\",\"https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332\",\"name\":\"Carolyn Clabo\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g\",\"caption\":\"Carolyn Clabo\"},\"description\":\"Biochemistry &amp; Biophysics - Communications &amp; Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology &amp; Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement &amp; Univ. Development (former)\",\"url\":\"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State | Biochemistry and Biophysics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/","og_locale":"en_US","og_type":"article","og_title":"UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State | Biochemistry and Biophysics","og_description":"The lab of Jean Cook, PhD, in the Department of Biochemistry and Biophysics, found how a chain of proteins called an MCM complex could enable the fast cell-division that makes some forms of cancer so dangerous. The study first author Jacob Matson, a PhD candidate in the Cook lab performed most of the experiments.","og_url":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/","og_site_name":"Biochemistry and Biophysics","article_publisher":"https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","article_published_time":"2017-12-13T00:20:00+00:00","article_modified_time":"2018-08-01T14:41:39+00:00","og_image":[{"width":287,"height":300,"url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg","type":"image\/jpeg"}],"author":"Carolyn Clabo","twitter_card":"summary_large_image","twitter_creator":"@UNC_BCBP","twitter_site":"@UNC_BCBP","twitter_misc":{"Written by":"Carolyn Clabo","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/"},"author":{"name":"Carolyn Clabo","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332"},"headline":"UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State","datePublished":"2017-12-13T00:20:00+00:00","dateModified":"2018-08-01T14:41:39+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/"},"wordCount":472,"publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg","keywords":["2017 newsletter","2017_student_year_in review","2017-faculty-year-in-review","2017-Year-in-Review","Cook","Faculty &amp; Lab News","News 2017","news_dept","News_StudentPostdocStaff_S17","recent news","Student News"],"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/","url":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/","name":"UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State | Biochemistry and Biophysics","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg","datePublished":"2017-12-13T00:20:00+00:00","dateModified":"2018-08-01T14:41:39+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#primaryimage","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg","width":287,"height":300,"caption":"Jean Cook, PhD"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/biochem\/"},{"@type":"ListItem","position":2,"name":"UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/biochem\/#website","url":"https:\/\/www.med.unc.edu\/biochem\/","name":"UNC Biochemistry and Biophysics","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/biochem\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/biochem\/#organization","name":"UNC Department of Biochemistry and Biophysics","url":"https:\/\/www.med.unc.edu\/biochem\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","contentUrl":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2017\/06\/BiochemistryAndBiophysics_logo_2c_rgb_v.png","width":488,"height":400,"caption":"UNC Department of Biochemistry and Biophysics"},"image":{"@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uncbiochemistryandbiophysics\/","https:\/\/x.com\/UNC_BCBP","https:\/\/www.instagram.com\/unc_bcbp\/","https:\/\/www.linkedin.com\/in\/unc-dept-of-biochem-biophysics-17a6187b\/"]},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/9693a4e0a76e8208ca2105ae25587332","name":"Carolyn Clabo","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/biochem\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/17dbaa9d9071e560a2c3a5001e790ad90c89faa270f92c82ab6e37b32c0cdef4?s=96&d=mm&r=g","caption":"Carolyn Clabo"},"description":"Biochemistry &amp; Biophysics - Communications &amp; Development - Admin. Support to Aziz Sancar MD PhD and Research Labs (current) Medicine - Oncology &amp; Hematology (former) UNC General Administration (former) Nursing - Research Center (former) Vice Chancellor's office of Advancement &amp; Univ. Development (former)","url":"https:\/\/www.med.unc.edu\/biochem\/author\/cclabo\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg","featured_image_medium":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2-287x300.jpeg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg","featured_image_large":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2.jpeg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/07\/unc-scientists-discover-proteins-keeping-stem-cells-in-their-undifferentiated-state-image2-150x157.jpeg","featured_image_alt":"Jean Cook, PhD","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/biochem\/category\/news\/"}],"tag_details":[{"name":"2017 newsletter","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/2017-newsletter\/"},{"name":"2017_student_year_in review","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/2017_student_year_in-review\/"},{"name":"2017-faculty-year-in-review","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/2017-faculty-year-in-review\/"},{"name":"2017-Year-in-Review","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/2017-year-in-review\/"},{"name":"Cook","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/cook\/"},{"name":"Faculty &amp; Lab News","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_faculty\/"},{"name":"News 2017","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_2017\/"},{"name":"news_dept","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_dept\/"},{"name":"News_StudentPostdocStaff_S17","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_studentpostdocstaff_s17\/"},{"name":"recent news","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/recent-news\/"},{"name":"Student News","link":"https:\/\/www.med.unc.edu\/biochem\/tag\/news_students\/"}],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/4508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/users\/41619"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/comments?post=4508"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/posts\/4508\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media\/4509"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media?parent=4508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/categories?post=4508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/tags?post=4508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}