{"id":7846,"date":"2018-10-18T15:49:10","date_gmt":"2018-10-18T19:49:10","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?p=7846"},"modified":"2019-10-29T12:31:05","modified_gmt":"2019-10-29T16:31:05","slug":"unc-scientists-solve-3-d-structure-of-cf-protein-in-active-inactive-states","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/biochem\/news\/unc-scientists-solve-3-d-structure-of-cf-protein-in-active-inactive-states\/","title":{"rendered":"UNC scientists solve 3-D structure of CF protein in active, inactive states"},"content":{"rendered":"<p>The labs of John Riordan at the UNC School of Medicine Biochemistry and Biophysics and James Chen at Oregon Health &amp; Science University published detailed cryo-electron microscopic analysis of the CFTR protein to gain insights into why a faulty chloride channel leads to serious disease.<\/p>\n<p>&#8212;<\/p>\n<p>Scientists at the UNC School of Medicine in collaboration with researchers at Oregon Health &amp; Science University have resolved the three-dimensional molecular structure of the protein that\u2019s defective in people with cystic fibrosis in the protein\u2019s active and inactive state. The discovery, published in the journal\u00a0<i>Biochemistry<\/i>, could open up new research avenues and help drug developers create enhanced pharmacotherapies to help people with CF.<\/p>\n<p>Much of the biochemistry work was done in the lab of John Riordan, PhD, distinguished professor of biochemistry and biophysics at UNC-Chapel Hill. In the late 1980s, Riordan\u2019s lab discovered the mutated gene responsible for CF. If a child receives a copy of this faulty gene from each parent, the child will develop CF. The protein encoded by this gene was termed the cystic fibrosis transmembrane regulator, or CFTR, which is the chloride channel in epithelial cells that populate the respiratory system. People with CF lack a functional epithelial chloride channel, which is essential for maintaining the proper balance of salt and water in lungs and other organs.\u00a0 One result of this is the production of thick, sticky mucus that becomes difficult to move out of the airways, leading to chronic infections and a shorter lifespan for most people with CF.<\/p>\n<p>In the Riordan lab, postdoctoral fellow Jonathan Fay, PhD, led experiments using single-particle cryo-electron microscopy to discover the molecular structure of CFTR in the presence of ATP \u2013 a complex organic chemical necessary for many processes in cells, including a working chloride ion channel crucial for proper lung function. To help capture structures of the CFTR protein in its active and inactive state, the Riordan lab stabilized the CFTR protein such that the channel was off when dephosphorylated and locked-on when phosphorylated.<\/p>\n<p>hese molecular structures reveal a unique repositioning of parts of the CFTR protein, providing insights into the structural transition between active and inactive functional states of CFTR.<\/p>\n<p>Moreover, Fay and colleagues observed details of this protein complex that differ from what other scientists have discovered in previous CFTR structures.<\/p>\n<figure id=\"attachment_8032\" class=\"thumbnail wp-caption aligncenter\" style=\"width: 266px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-8032\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/10\/John-Riordan-lab-UNC-photo-collage-256x300.png\" alt=\"UNC scientists solve 3-D structure of CF protein in active, inactive states (Riordan lab)\" width=\"256\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/10\/John-Riordan-lab-UNC-photo-collage-256x300.png 256w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/10\/John-Riordan-lab-UNC-photo-collage-437x512.png 437w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2018\/10\/John-Riordan-lab-UNC-photo-collage.png 628w\" sizes=\"auto, (max-width: 256px) 100vw, 256px\" \/><figcaption class=\"caption wp-caption-text\">UNC scientists solve 3-D structure of CF protein in active, inactive states (Riordan lab)<\/figcaption><\/figure>\n<p>\u201cIt is really amazing how much cryo-EM technologies have advanced and how using these techniques can allow us to visualize different states of the channel,\u201d Fay said. \u201cI think our results are very exciting.\u00a0 We discovered a new portal which presents a promising new area of the channel to target and control CFTR channel function.\u201d<\/p>\n<p>And if researchers can successfully target and control the function of that channel, then they could create more precise therapies to better treat some people with CF.<\/p>\n<p><i>Co-authors included Luba Aleksandrov, Timothy Jensen, Liying Cui, Joe Kousouros, Lihua He, Adrei Aleksandrov, all from UNC-Chapel Hill, and Drew Gingerich from OHSU.\u00a0<\/i><i>John Riordan retired from UNC this summer.<\/i><\/p>\n<p><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.8b00763\">Link to publication<\/a><\/p>\n<p><a href=\"http:\/\/news.unchealthcare.org\/news\/2018\/october\/unc-scientists-solve-3-d-structure-of-cf-protein-in-active-inactive-states\">Link to Vital Signs with both images<\/a><\/p>\n<p>Story courtesy of\u00a0<i><a href=\"http:\/\/news.unchealthcare.org\/news-team\">Mark Derewicz<\/a>, Communications Manager for\u00a0UNC School of Medicine<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the Riordan lab, postdoctoral fellow Jonathan Fay, PhD, led experiments using single-particle cryoEM to discover&#8230;<\/p>\n","protected":false},"author":41619,"featured_media":8037,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[59,39,78,182,211,36,47,179,12],"class_list":["post-7846","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-2018-newsletter","tag-2018-year-in-review","tag-biochemistry-and-biophysics","tag-cryoem-news","tag-jonathan-fay","tag-news_2018","tag-news_studentpostdocstaff_s18","tag-news_postdoc-scholars","tag-news_postdoc-schollars","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNC scientists solve 3-D structure of CF protein in active, inactive states | Biochemistry 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