{"id":2322,"date":"2026-01-12T13:41:11","date_gmt":"2026-01-12T18:41:11","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/?page_id=2322"},"modified":"2026-01-21T10:50:13","modified_gmt":"2026-01-21T15:50:13","slug":"pancreatic-cancer-associated-venous-thrombosis","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/research\/pancreatic-cancer-associated-venous-thrombosis\/","title":{"rendered":"Pancreatic cancer-associated venous thrombosis"},"content":{"rendered":"<p>Cancer patients have a 4- to 9-fold increased risk of venous thrombosmbolism (VTE) compared with the general population. We are particularly interested in the mechanisms underlying pancreatic cancer-associated thrombosis (CAT), as pancreatic cancer has one of the highest incidences of VTE. Using mouse models of pancreatic CAT, we have identified three key pathways to venous thrombosis: (1) <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28834179\">tissue factor-positive extracellular vesicles (TF+EVs)<\/a>, (2) <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31048354\">neutrophils and neutrophil extracellular traps (NETs)<\/a> and (3) <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33496742\">plasminogen activator inhibitor-1 (PAI-1)<\/a>.<\/p>\n<figure id=\"attachment_2343\" class=\"thumbnail wp-caption alignnone\" style=\"width: 910px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2343 size-full\" src=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-content\/uploads\/sites\/1400\/2026\/01\/Picture5600.png\" alt=\"\" width=\"900\" height=\"496\" srcset=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-content\/uploads\/sites\/1400\/2026\/01\/Picture5600.png 900w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-content\/uploads\/sites\/1400\/2026\/01\/Picture5600-300x165.png 300w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-content\/uploads\/sites\/1400\/2026\/01\/Picture5600-768x423.png 768w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-content\/uploads\/sites\/1400\/2026\/01\/Picture5600-600x331.png 600w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><figcaption class=\"caption wp-caption-text\">Pathways of cancer-associated thrombosis. Pathway 1: tumors release TF-positive extracellular vesicles that activate the coagulation cascade and platelets and increase the risk of VTE. Pathway 2: tumors release granulocyte-colony stimulating factor (G-CSF) that increases the number of neutrophils in the circulation and enhances NET formation and the risk of VTE. Pathway 3: tumors release PAI-1 that increases the risk of VTE by inhibiting plasmin generation and fibrinolysis. NET, neutrophil extracellular trap; PAI-1, plasminogen activator inhibitor-1; TF, tissue factor<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Cancer patients have a 4- to 9-fold increased risk of venous thrombosmbolism (VTE) compared with the general population. We are particularly interested in the mechanisms underlying pancreatic cancer-associated thrombosis (CAT), as pancreatic cancer has one of the highest incidences of VTE. Using mouse models of pancreatic CAT, we have identified three key pathways to venous &hellip; <a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/research\/pancreatic-cancer-associated-venous-thrombosis\/\" aria-label=\"Read more about Pancreatic cancer-associated venous thrombosis\">Read more<\/a><\/p>\n","protected":false},"author":42253,"featured_media":0,"parent":2319,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2322","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-json\/wp\/v2\/pages\/2322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-json\/wp\/v2\/users\/42253"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-json\/wp\/v2\/comments?post=2322"}],"version-history":[{"count":7,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-json\/wp\/v2\/pages\/2322\/revisions"}],"predecessor-version":[{"id":2495,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-json\/wp\/v2\/pages\/2322\/revisions\/2495"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-json\/wp\/v2\/pages\/2319"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/hisadalab\/wp-json\/wp\/v2\/media?parent=2322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}