Here is a summary of the careers of each of the members along with information about their current research and research interests.

Dr. Erica Sparkenbaugh, Ph.D.

After graduating with a BS in Biology from Allegheny College in Meadville, PA, I pursued a Ph.D. in Pharmacology and Toxicology at Michigan State University in the lab of Bob Roth. I investigated mechanisms of drug-induced liver injury and developed an interest in the crosstalk of coagulation and inflammation. I joined the Pawlinski lab as a post-doctoral fellow in 2012 to investigate these pathways in mouse models of sickle cell disease and heart failure. Since that time, I have developed a deep interest in examining the mechanisms of thrombin generation and end-organ failure in sickle cell disease. I have two major ongoing projects in the laboratory. (1) Investigate the mechanism of thrombin generation in sickle cell disease during a steady-state and vaso-occlusive crisis and (2) Determine the best anticoagulant treatment strategy to reduce thrombotic complications and end-organ damage in sickle cell disease.

January 2012 – Joined the Pawlinski Lab

December 2012 – Received Outstanding Abstract Award and presented at the ASH meeting in Atlanta

June 2013 – Received F32 Individual Postdoctoral Fellowship to investigate the role of PAR-2 in pulmonary hypertension of sickle cell disease

July 2013 – Presented at the ISTH World Congress in Amsterdam

May 2014 – Presented at the AHA ATVB Meeting in Toronto

June 2015 – Presented at the ISTH World Congress in Toronto

June 2016 – Received an American Heart Association (AHA) Postdoctoral Fellowship to evaluate the role of the extrinsic coagulation cascade in the end-organ failure of sickle cell disease