{"id":3613,"date":"2020-12-07T10:03:48","date_gmt":"2020-12-07T15:03:48","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?post_type=directory&#038;p=3613"},"modified":"2026-01-20T14:12:31","modified_gmt":"2026-01-20T19:12:31","slug":"maria-aleman-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/directory\/maria-aleman-phd\/","title":{"rendered":"Maria Aleman, PhD"},"content":{"rendered":"<h4>Research Interests<\/h4>\n<h4><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3643 alignright\" src=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/12\/400dpiLogoCropped-300x249.jpg\" alt=\"Trained Mentor\" width=\"92\" height=\"76\" srcset=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/12\/400dpiLogoCropped-300x249.jpg 300w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/12\/400dpiLogoCropped-1024x849.jpg 1024w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/12\/400dpiLogoCropped-768x637.jpg 768w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/12\/400dpiLogoCropped-600x497.jpg 600w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/12\/400dpiLogoCropped.jpg 1397w\" sizes=\"auto, (max-width: 92px) 100vw, 92px\" \/><\/h4>\n<ul>\n<li>Blood and vascular biology<\/li>\n<li>Erythropoiesis<\/li>\n<li>Iron metabolism<\/li>\n<li>RNA regulation<\/li>\n<li>Coagulation<\/li>\n<li>Non-malignant hematology<\/li>\n<\/ul>\n<h4>Research Synopsis<\/h4>\n<p>The broad goal of our research is to understand basic mechanisms regulating erythropoiesis (red blood cell differentiation and maturation). Erythropoiesis begins in the bone marrow where hematopoietic stem cells differentiate through multiple stages of multipotent progenitor cells until ultimately committing to the erythroid lineage. Subsequent differentiation down this track involves coordinated gene expression, including RNA regulation, and accumulation of iron for heme biosynthesis and hemoglobin production.\u00a0 Our current work focuses on a family of dual functional proteins (poly C binding proteins) which both regulate RNA processing and chaperone iron within cells. Using biochemical, cellular, and in vivo models we explore the cross talk between iron trafficking and RNA regulation mediated by poly C binding proteins and how these activities are modulated by disease.<\/p>\n<h4><a href=\"https:\/\/tarheels.live\/alemanlab\/\">Aleman Lab website<\/a><\/h4>\n","protected":false},"excerpt":{"rendered":"<p>Department of Pathology and Laboratory Medicine<\/p>\n","protected":false},"featured_media":3689,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-3613","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Maria Aleman, PhD | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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