{"id":4815,"date":"2023-01-04T11:02:17","date_gmt":"2023-01-04T16:02:17","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?post_type=directory&#038;p=4815"},"modified":"2023-01-04T11:13:38","modified_gmt":"2023-01-04T16:13:38","slug":"silvia-b-ramos-md-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/directory\/silvia-b-ramos-md-phd\/","title":{"rendered":"Silvia B. Ramos, MD, PhD"},"content":{"rendered":"<p style=\"margin: 0in;text-align: justify\"><span style=\"font-family: 'Arial',sans-serif\">Our research focus is on RNA-binding proteins, particularly on ZFP36L2 (Zinc Finger Protein 36 Like 2). So far, the known function of this protein is to bind to mRNAs containing specific sequences rich in Adenine and Uridine elements (AREs). Upon binding, this interaction triggers mRNA decay, decreasing the expression of these targeted transcripts and consequently protein levels. We created a mouse model lacking ZFP36L2, which intriguingly resulted in severe pancytopenia in the peripheral blood with decreased cellularity at the bone-marrow, resembling Myelodysplastic Syndrome (MDS) at a young age. I aim to integrate our research focus on the RNA field with clinical and basic immunological concepts. <\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"margin: 0in;text-align: justify\"><span style=\"font-family: 'Arial',sans-serif\">I am an enthusiastic and solid medical scientist, passionate about RNA and hematopoietic stem cells (HSC), an extremely relevant research area of interest of the BRC. Eventually, I aim to improve our transfusion and bone marrow transplant practices based in novel discoveries. Our lab is committed to embrace individuals from all backgrounds and groups, including, but not restricted to those from historically excluded minorities. The diversity of our team creates an inclusive, collegial, supportive-equitable team, sustained by our different backgrounds united towards scientific understanding. We consider the education process as being dynamic and transformative. In ways that that the unforeseen novel knowledge leads a to an empowered society. These are also goals shared by the BRC mission at UNC.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/ramoslab.web.unc.edu\/\" target=\"_blank\" rel=\"noopener\">Silvia Ramos, MD, PhD Research Lab Website<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our research focus is on RNA-binding proteins, particularly on ZFP36L2 (Zinc Finger Protein 36 Like 2). So far, the known function of this protein is to bind to mRNAs containing specific sequences rich in Adenine and Uridine elements (AREs). Upon binding, this interaction triggers mRNA decay, decreasing the expression of these targeted transcripts and consequently &hellip; <a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/directory\/silvia-b-ramos-md-phd\/\" aria-label=\"Read more about Silvia B. Ramos, MD, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":4816,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-4815","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Silvia B. Ramos, MD, PhD | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/directory\/silvia-b-ramos-md-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Silvia B. Ramos, MD, PhD | UNC Blood Research Center\" \/>\n<meta property=\"og:description\" content=\"Our research focus is on RNA-binding proteins, particularly on ZFP36L2 (Zinc Finger Protein 36 Like 2). So far, the known function of this protein is to bind to mRNAs containing specific sequences rich in Adenine and Uridine elements (AREs). Upon binding, this interaction triggers mRNA decay, decreasing the expression of these targeted transcripts and consequently &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/directory\/silvia-b-ramos-md-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Blood Research Center\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-04T16:13:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2023\/01\/ramos_silvia_2017.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"2100\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/directory\/silvia-b-ramos-md-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/directory\/silvia-b-ramos-md-phd\/\",\"name\":\"Silvia B. 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Ramos, MD, PhD."],"_upd_reverse_display_name":["Ramos, Silvia"],"_upd_last_name":["Ramos"],"_upd_first_name":["Silvia"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<p style=\"margin: 0in\"><strong><span style=\"font-family: 'Arial',sans-serif\">Associate Professor at the Biochemistry and Biophysics Department<\/span><\/strong><\/p>\r\nEmail: <a href=\"mailto:sramos@med.unc.edu\">sramos@med.unc.edu<\/a>\r\n\r\noffice phone - (919) 962-5301\r\n\r\nOffice: 241 Wilson Hall\r\n\r\nResearch Lab: 204 Fordham Hall\r\n133 North Medical Dr\r\n\r\nChapel Hill NC 27599\r\n\r\nCB#7100 (UNC internal mail)\r\nhttps:\/\/ramoslab.web.unc.edu\/"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"sramos@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"(919) 962-5301"}]],"_upd_address":[[{"address":{"address-1":"241 Wilson Hall","address-2":"","campus-box":"7100","city":"Chapel Hill","state":"NC","zip":"27599"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/directory\/4815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/directory\/4815\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/media\/4816"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/media?parent=4815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}