{"id":2239,"date":"2020-01-21T11:46:14","date_gmt":"2020-01-21T16:46:14","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?page_id=2239"},"modified":"2025-05-16T10:21:20","modified_gmt":"2025-05-16T14:21:20","slug":"unc-blood-research-center","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/","title":{"rendered":"UNC Blood Research Center"},"content":{"rendered":"<div class=\"row  oscitas-bootstrap-container\">\n<div class=\"col-lg-6 col-md-6 col-xs-12 col-sm-6 oscitas-bootstrap-container\">\n\n<!-- iframe plugin v.5.2 wordpress.org\/plugins\/iframe\/ -->\n<iframe loading=\"lazy\" src=\"https:\/\/uncch.hosted.panopto.com\/Panopto\/Pages\/Embed.aspx?id=5f74a318-a0ca-4081-969f-afd90131e888&#038;autoplay=false&#038;offerviewer=true&#038;showtitle=true&#038;showbrand=true&#038;captions=true&#038;interactivity=all\" height=\"405\" width=\"720\" style=\"border: 1px solid #464646;\" 0=\"allowfullscreen\" allow=\"autoplay\" scrolling=\"yes\" class=\"iframe-class\" frameborder=\"0\"><\/iframe>\n\n<p style=\"text-align: left;\"><\/div>\n<div class=\"col-lg-6 col-md-6 col-xs-12 col-sm-6 oscitas-bootstrap-container\">\n<a class=\"btn btn-primary btn-lg btn-block  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/bsky.app\/profile\/unc-brc.bsky.social\">Follow us at our Bluesky account @unc-brc.bsky.social<\/a>\n<div class=\"clean-quote\"><p>The UNC Blood Research Center (BRC) was established to promote interdisciplinary research in non-malignant blood disorders across UNC. It will seek to advance the work in the following specific areas.<br\/><\/p><\/div>\n<\/div>\n<\/div>\n<hr class=\" rule-thin osc-rule\" \/>\n<div class=\"row  oscitas-bootstrap-container\">\n<div class=\"col-lg-6 col-md-6 col-xs-12 col-sm-6 oscitas-bootstrap-container\">\n<h2 class=\"www-somHeader\">Thrombosis<\/h2>\n<p>One in four of the US population will succumb to a terminal thrombotic event, such as: myocardial infarction, stroke, or venous thromboembolism.<\/p>\n<p>Basic science discoveries have paved the way towards better prophylactic and therapeutic approaches to thrombosis. However, a better understanding of the mechanisms underlying thrombosis and prevention without any risk of bleeding remains an unmet need. The BRC seeks to investigate potential approaches to both aims.<\/div>\n<div class=\"col-lg-6 col-md-6 col-xs-12 col-sm-6 oscitas-bootstrap-container\">\n<h2 class=\"www-somHeader\">Bleeding Disorders<\/h2>\n<p>UNC is a world leader in hemophilia, from the development and administration of the first coagulation factor VIII concentrate to the role of the Chapel Hill dog colonies of the Francis Owen Blood Research Center in the pre-clinical testing of protein and gene therapies. The BRC aims to address the broad challenges that remain in numerous other inherited and acquired bleeding disorders.<\/div>\n<\/div>\n<h2 class=\"www-somHeader\">Sickle Cell Disease<\/h2>\n<p>Sickle cell disease affects approximately 100,000 Americans but accounts for an estimated 300,000 births worldwide every year, primarily in sub-Saharan Africa and the Indian sub-continent.<\/p>\n<p>Compared to many other areas of medicine, the development of impactful therapies in sickle cell disease remains inadequate. We will continue to expand our research efforts to this under-served patient population into the future.<\/p>\n<hr \/>\n<div class=\"row  oscitas-bootstrap-container\">\n<div class=\"col-lg-6 col-md-12 col-xs-12 col-sm-12 oscitas-bootstrap-container\">\n<h2 class=\"www-somHeader\">Events\/Seminars<\/h2>\n<p class=\"www-somHeader\"><div class=\"event-calendar\"><div class=\"event-post\"><div class=\"event-date\"><time>May<span>01<\/span><\/time><\/div><div class=\"event-details\"><p>Friday 11:00 am<\/p><h4 class=\"media-heading\"><a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/event\/brc-seminar-series-spring-2026-jessica-cardenas\/\" rel=\"bookmark\">BRC Seminar Series Spring 2026: Jessica Cardenas<\/a><\/h4><\/div><\/div><div class=\"event-post\"><div class=\"event-date\"><time>May<span>05<\/span><\/time><\/div><div class=\"event-details\"><p>Tuesday 9:00 am<\/p><h4 class=\"media-heading\"><a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/event\/tuesday-brc-lab-meeting-70\/\" rel=\"bookmark\">Tuesday BRC Lab Meeting<\/a><\/h4><\/div><\/div><div class=\"event-post\"><div class=\"event-date\"><time>May<span>08<\/span><\/time><\/div><div class=\"event-details\"><p>Friday 11:00 am<\/p><h4 class=\"media-heading\"><a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/event\/brc-seminar-series-spring-2026-rakesh-patel\/\" rel=\"bookmark\">BRC Seminar Series Spring 2026: Rakesh Patel<\/a><\/h4><\/div><\/div><div class=\"event-post\"><div class=\"event-date\"><time>May<span>15<\/span><\/time><\/div><div class=\"event-details\"><p>Friday 11:00 am<\/p><h4 class=\"media-heading\"><a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/event\/brc-seminar-series-spring-2026-michele-lambert\/\" rel=\"bookmark\">BRC Seminar Series Spring 2026: Michele Lambert<\/a><\/h4><\/div><\/div><\/div><!-- .hfeed --><p class=\"tribe-events-widget-link\"><a class=\"btn btn-primary btn-sm\" href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/events\/\" rel=\"bookmark\">View All Events<\/a><\/p>\n<\/div>\n<div class=\"col-lg-6 col-md-12 col-xs-12 col-sm-12 oscitas-bootstrap-container\">\n<\/div>\n<\/div>\n<h2 class=\"www-somHeader\"><span style=\"color: inherit;\">News<\/span><\/h2>\n        <div class=\"wc-cards-feature\">\n        <div class=\"wc-cards-feature__info\">            <h2 class=\"wc-cards-feature__title\">Recent Posts<\/h2>            <p class=\"wc-cards-feature__description\">News from the Blood Research Center<\/p>        <a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/category\/news\/\" class=\"wc-more-link\">More posts<\/a>        <\/div>\n        <div class=\"wc-cards\"><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2026\/04\/matthew-vander-ploeg-published-his-first-author-manuscript-in-blood-advances\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"260\" height=\"379\" src=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2026\/04\/Matthew-Vander-Ploeg.avif\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"\" srcset=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2026\/04\/Matthew-Vander-Ploeg.avif 260w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2026\/04\/Matthew-Vander-Ploeg-206x300.avif 206w\" sizes=\"auto, (max-width: 260px) 100vw, 260px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">1 day ago<\/p><h3 class=\"wc-card__title wc-card__title--3\">Matthew Vander Ploeg published his first author manuscript in Blood Advances<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Matthew Vander Ploeg, a graduate student in BCBP and a member of the BRC in Dr. Bergmeier&#8217;s lab, published his first author manuscript in Blood Advances. The study describes the development of high-throughput platelet migration assay, facilitated by novel deep learning-based image analysis pipeline. Using this new platform, Matt was able to show that platelet &hellip;<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Matthew Vander Ploeg published his first author manuscript in Blood Advances\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2026\/04\/dr-yohei-hisada-spoke-at-the-international-conference-on-thrombosis-and-hemostasis-issues-in-cancer\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2022\/01\/Yohei-Hisada-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"\" srcset=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2022\/01\/Yohei-Hisada-600x600.jpg 600w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2022\/01\/Yohei-Hisada-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">2 days ago<\/p><h3 class=\"wc-card__title wc-card__title--3\">Dr. Yohei Hisada spoke at the International Conference on Thrombosis and Hemostasis Issues in Cancer<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Dr. Yohei Hisada delivered an invited talk during a plenary session at the International Conference on Thrombosis and Hemostasis Issues in Cancer (https:\/\/icthic.com\/en). The title of the presentation was \u201cTissue Factor-Driven Coagulopathy and Bleeding in Acute Leukemia: Clinical and Preclinical Insights.\u201d<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Dr. Yohei Hisada spoke at the International Conference on Thrombosis and Hemostasis Issues in Cancer\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2026\/04\/david-paul-and-david-rocco-from-bergmeier-lab-publish-co-first-author-paper-in-blood\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2022\/10\/David-Paul-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"\" srcset=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2022\/10\/David-Paul-600x600.jpg 600w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2022\/10\/David-Paul-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">2 weeks ago<\/p><h3 class=\"wc-card__title wc-card__title--3\">David Paul, PhD and David Rocco from the Bergmeier Lab publish co-first author paper in Blood<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">David Paul, PhD (Assistant Professor) and David Rocco (graduate student, Cell Biology and Physiology) from the Bergmeier lab publish co-first author paper in Blood describing a new signaling pathway critical for platelet adhesion under arterial shear conditions. The findings of this study markedly improve our understanding of G protein signaling and integrin function in platelets, &hellip;<\/p><p class=\"wc-card__more\" aria-label=\"Read more about David Paul, PhD and David Rocco from the Bergmeier Lab publish co-first author paper in Blood\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article>        <\/div>\n        <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Sickle Cell Disease Sickle cell disease affects approximately 100,000 Americans but accounts for an estimated 300,000 births worldwide every year, primarily in sub-Saharan Africa and the Indian sub-continent. Compared to many other areas of medicine, the development of impactful therapies in sickle cell disease remains inadequate. We will continue to expand our research efforts to &hellip; <a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2026\/04\/david-paul-and-david-rocco-from-bergmeier-lab-publish-co-first-author-paper-in-blood\/\" aria-label=\"Read more about David Paul, PhD and David Rocco from the Bergmeier Lab publish co-first author paper in Blood\">Read more<\/a><\/p>\n","protected":false},"author":79967,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2239","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNC Blood Research Center | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UNC Blood Research Center | UNC Blood Research Center\" \/>\n<meta property=\"og:description\" content=\"Sickle Cell Disease Sickle cell disease affects approximately 100,000 Americans but accounts for an estimated 300,000 births worldwide every year, primarily in sub-Saharan Africa and the Indian sub-continent. Compared to many other areas of medicine, the development of impactful therapies in sickle cell disease remains inadequate. 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