{"id":3523,"date":"2020-10-14T13:16:39","date_gmt":"2020-10-14T17:16:39","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?page_id=3523"},"modified":"2024-02-13T14:40:52","modified_gmt":"2024-02-13T19:40:52","slug":"current-studies-htc","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/","title":{"rendered":"Research HTC"},"content":{"rendered":"

Current Clinical Research \u2013 UNC Blood Research Center\u00a0 \u00a0<\/strong>*as of February 13, 2024*<\/strong><\/h4>\n

 <\/p>\n

Active Studies \u2013 Start-Up Phase<\/u><\/strong><\/h4>\n

BMN 270-401<\/strong>– A Long-Term Follow-Up Study in Subjects With Severe Hemophilia A Who Received BMN 270, an Adeno-Associated Virus Vector-Mediated Gene Transfer of Human Factor VIII in a Prior BioMarin Clinical Trial<\/p>\n

Please click here<\/a> for more information.<\/p>\n

CSL222_3003<\/strong>\u00a0\u2013 Long-Term Follow-Up Study of Male Adults With Hemophilia B Previously Treated With Etranacogene Dezaparvovec (CSL222)
\nPlease click here<\/a> for more information.<\/p>\n

SPK-8011-302<\/strong> – Phase 3 gene therapy study of SPK-8011 in adults with severe or moderately severe hemophilia A (KEYSTONESM 1)
\nPlease click here<\/a> for more information.<\/p>\n

AHAEMI \u2013 <\/strong>Emicizumab in Patients With Acquired Hemophilia A: Multicenter, Single-Arm, Open-Label Clinical Trial
\nPlease click here<\/a> for more information.<\/p>\n

 <\/p>\n

Active Studies – Currently Open to Enrollment<\/u><\/strong><\/h4>\n

STOP-HHT<\/strong> – A Phase II\/III randomized, placebo controlled, double blind study to evaluate the effects of up to 24 weeks of low dose pazopanib on hereditary hemorrhagic telangiectasia related epistaxis and anemia
\nPlease click here<\/a> for more information.<\/p>\n

P200 – <\/strong>United States Thrombotic Microangiopathy (USTMA) Thrombotic Thrombocytopenic Purpura (TTP) Clinical Data and Biologic Sample Repository
\nPlease click here<\/a> for more information.<\/p>\n

BVMC3 –<\/strong> Brain Vascular Malformation Consortium (BVMC3) Project 3: Cerebral Hemorrhage Risk in Hereditary Hemorrhagic Telangiectasia
\nPlease click here<\/a> for more information.<\/p>\n

 <\/p>\n

Active Studies \u2013 Currently Following Subjects or Data Analysis Only<\/u><\/strong><\/h4>\n

PATH-HHT<\/strong> \u2013 Placebo-controlled, double-blind study of pomalidomide in patients with hereditary hemorrhagic telangiectasia (HHT).
\nPlease\u00a0click here<\/a> for more information.<\/p>\n

GENEr8-1<\/strong> (BMN 270-301)<\/strong> \u2013 Phase III, gene therapy trial for adults with severe hemophilia A.
\nPlease\u00a0click here<\/a> for more information.<\/p>\n

HOPE-B (CSL222)<\/strong> \u2013 Phase III, gene therapy trial for adults with severe or moderately severe hemophilia B.
\nPlease\u00a0click here<\/a> for more information.<\/p>\n

AVA-ITP-401<\/strong>\u2013 Phase IV trial of safety and satisfaction in adults with chronic Immune Thrombocytopenia (ITP) after switching to avatrombopag from eltrombopag or romiplostim.
\nPlease\u00a0click here<\/a> for more information.<\/p>\n

<\/h4>\n

Recently Closed Studies (Jan 1 2023 \u2013 Present)<\/u><\/strong><\/h4>\n

ACCRU-SC-1601 (EVE)<\/strong> \u2013 Randomized, phase III trial of apixaban in preventing secondary cancer related venous thrombosis.
\nPlease\u00a0click here<\/a> for more information.<\/p>\n

MOSH Outcomes<\/strong> \u2013 An observational study of the natural history of outcomes in hemophiliacs undergoing major orthopedic surgery.
\nPlease click here<\/a> for more information.<\/p>\n

 <\/p>\n

To learn more about our research, inquiries can be sent to: unchtcresearch@med.unc.edu<\/a><\/h4>\n","protected":false},"excerpt":{"rendered":"

Current Clinical Research \u2013 UNC Blood Research Center\u00a0 \u00a0*as of February 13, 2024*   Active Studies \u2013 Start-Up Phase BMN 270-401– A Long-Term Follow-Up Study in Subjects With Severe Hemophilia A Who Received BMN 270, an Adeno-Associated Virus Vector-Mediated Gene Transfer of Human Factor VIII in a Prior BioMarin Clinical Trial Please click here for … Read more<\/a><\/p>\n","protected":false},"author":15383,"featured_media":0,"parent":2324,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-3523","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nResearch HTC | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research HTC | UNC Blood Research Center\" \/>\n<meta property=\"og:description\" content=\"Current Clinical Research \u2013 UNC Blood Research Center\u00a0 \u00a0*as of February 13, 2024*   Active Studies \u2013 Start-Up Phase BMN 270-401– A Long-Term Follow-Up Study in Subjects With Severe Hemophilia A Who Received BMN 270, an Adeno-Associated Virus Vector-Mediated Gene Transfer of Human Factor VIII in a Prior BioMarin Clinical Trial Please click here for … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Blood Research Center\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-13T19:40:52+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/\",\"url\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/\",\"name\":\"Research HTC | UNC Blood Research Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website\"},\"datePublished\":\"2020-10-14T17:16:39+00:00\",\"dateModified\":\"2024-02-13T19:40:52+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Clinical Trials\",\"item\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Research HTC\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/\",\"name\":\"UNC Blood Research Center\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Research HTC | UNC Blood Research Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/","og_locale":"en_US","og_type":"article","og_title":"Research HTC | UNC Blood Research Center","og_description":"Current Clinical Research \u2013 UNC Blood Research Center\u00a0 \u00a0*as of February 13, 2024*   Active Studies \u2013 Start-Up Phase BMN 270-401– A Long-Term Follow-Up Study in Subjects With Severe Hemophilia A Who Received BMN 270, an Adeno-Associated Virus Vector-Mediated Gene Transfer of Human Factor VIII in a Prior BioMarin Clinical Trial Please click here for … Read more","og_url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/","og_site_name":"UNC Blood Research Center","article_modified_time":"2024-02-13T19:40:52+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/","url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/","name":"Research HTC | UNC Blood Research Center","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website"},"datePublished":"2020-10-14T17:16:39+00:00","dateModified":"2024-02-13T19:40:52+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/current-studies-htc\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/"},{"@type":"ListItem","position":2,"name":"Clinical Trials","item":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/"},{"@type":"ListItem","position":3,"name":"Research HTC"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website","url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/","name":"UNC Blood Research Center","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/pages\/3523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/users\/15383"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/comments?post=3523"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/pages\/3523\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/pages\/2324"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/media?parent=3523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}