{"id":3531,"date":"2020-10-14T14:04:24","date_gmt":"2020-10-14T18:04:24","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?page_id=3531"},"modified":"2024-02-16T09:52:13","modified_gmt":"2024-02-16T14:52:13","slug":"sickle-cell-disease-research","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/clinical-trials\/sickle-cell-disease-research\/","title":{"rendered":"Sickle Cell Disease Research"},"content":{"rendered":"

The UNC Comprehensive Sickle Cell Program provides cutting edge treatment to patients of all ages with sickle cell disease.\u00a0 A vital component of a comprehensive program is clinical research, and we are able to offer our patient population the opportunity to participate in clinical research studies, both industry-sponsored and investigator-initiated.\u00a0 Two medications, crizanlizumab and voxelotor, and a gene therapy have received FDA approval for the treatment of sickle cell due in part to our patient’s willingness to participate in clinical research.<\/h4>\n

For more information about Sickle Cell Disease research, please visit: SCD Research<\/a><\/strong><\/h4>\n

<\/h4>\n

Active Enrolling Studies<\/u><\/strong><\/h4>\n

 <\/p>\n

    \n
  1. \n

    An Open-label, Expanded Access Protocol for Pediatric Patients with Sickle Cell Disease Who Have No Alternative Treatment Options<\/h4>\n<\/li>\n
  2. \n

    Identifying barriers to pediatric to adult transition in Sickle Cell Disease using two data collection tools via telehealth vs in-person<\/h4>\n<\/li>\n
  3. \n

    Sickle Cell Disease (SCD) Biochip: Towards a Simple and Reliable Way to Monitor Sickle Cell Disease<\/h4>\n<\/li>\n
  4. \n

    Achieving Understanding of the Natural history of sickle cell Trait (AUNT)<\/h4>\n<\/li>\n
  5. \n

    A Prospective Study to Evaluate the Disease Status in Patients with Sickle Cell Disease: A Globin Regional Data and Discovery (GRNDaD) Network<\/h4>\n<\/li>\n
  6. \n

    Implementing the Infusion Clinic Model In Sickle Cell Disease<\/h4>\n<\/li>\n
  7. \n

    Improving the Implementation of Cardiac Screening in Sickle Cell Disease<\/h4>\n<\/li>\n
  8. \n

    Low Oxygen in Pregnant Women with Sickle Cell Disease<\/h4>\n<\/li>\n
  9. \n

    A pilot study assessing p16 levels in patients with sickle cell disease at UNC<\/h4>\n<\/li>\n
  10. \n

    Hydroxyurea Pharmacokinetics and Pharmacodynamics in Adults with Sickle Cell Anemia<\/h4>\n<\/li>\n
  11. \n

    Red Blood Cell Survival Study: The Impact of Oxidative Stress on Erythocyte Biology<\/h4>\n<\/li>\n
  12. \n

    An Adaptive, Randomized, Placebo-controlled, Double-blind, Multi-center Study of Oral FT-4202, a Pyruvate Kinase Activator in Patients with Sickle Cell Disease (Hibiscus)<\/h4>\n<\/li>\n
  13. \n

    A Phase 2\/3 Randomized, Multicenter Study of GBT021601 Administered Orally to Participants with Sickle Cell Disease and an Open-Label Pharmacokinetics Study in Pediatric Participants with Sickle Cell Disease<\/h4>\n<\/li>\n
  14. \n

    An Open-label Extension Study to Evaluate the Long-term Safety of GBT021601 Administered to Participants with Sickle Cell Disease Who Have Participated in a GBT021601 Clinical Trial<\/h4>\n<\/li>\n
  15. \n

    A Phase 1 Open-Label, Multiple-Dose Study to Evaluate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of FTX-6058 in Subjects with Sickle Cell Disease (SCD)<\/h4>\n<\/li>\n
  16. \n

    An Open-label Mechanistic Study to Assess the Pharmacokinetics, Pharmacodynamics and Safety of Orally Administered Epeleuton in Patients with Sickle Cell Disease<\/h4>\n<\/li>\n
  17. \n

    BMT CTN 1507: Reduced Intensity Conditioning for Haploidentical Bone Marrow Transplantation in Patients with Symptomatic Sickle Cell Disease<\/h4>\n<\/li>\n
  18. \n

    Sickle cell Transplant Evaluation of Long term and LAte-effects Registry (STELLAR)<\/h4>\n<\/li>\n<\/ol>\n

    <\/h4>\n","protected":false},"excerpt":{"rendered":"

    The UNC Comprehensive Sickle Cell Program provides cutting edge treatment to patients of all ages with sickle cell disease.\u00a0 A vital component of a comprehensive program is clinical research, and we are able to offer our patient population the opportunity to participate in clinical research studies, both industry-sponsored and investigator-initiated.\u00a0 Two medications, crizanlizumab and voxelotor, … Read more<\/a><\/p>\n","protected":false},"author":15383,"featured_media":0,"parent":2324,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-3531","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nSickle Cell Disease Research | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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