{"id":3553,"date":"2020-10-20T10:22:31","date_gmt":"2020-10-20T14:22:31","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?p=3553"},"modified":"2020-10-20T11:58:32","modified_gmt":"2020-10-20T15:58:32","slug":"blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/","title":{"rendered":"David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood"},"content":{"rendered":"<h4 class=\"wi-article-title article-title-main\">Talin-1 is the principal platelet Rap1 effector of integrin activation<\/h4>\n<div class=\"article-groups left-flag\"><span class=\"article-client_type\">PLATELETS AND THROMBOPOIESIS<\/span><span class=\"pipe\">|<\/span> <span class=\"article-date\">September 3, 2020<\/span><\/div>\n<div><\/div>\n<p>Recent Blood paper publication, collaborated with Mark Ginsberg, MD at UCSD to identify a unique mechanism regulating integrin-mediated platelet adhesion at sites of vascular injury:<\/p>\n<p>Wofgang Bergmeier, PhD and David Paul, PhD are co-authors on this study, showing that the small GTPase directly interacts with the cytoskeletal adapter protein, talin, to trigger integrin activation following platelet stimulation. This mechanism is unique as other blood cells depend on an intermediary protein that links Rap1 and talin. It is likely that this is an adaptation by platelets to be able to make firm adhesive contacts in a high shear environment. A better understanding of how platelet integrin function is regulated could lead to the development of better anti platelet drugs<\/p>\n<p><strong><a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/10\/bloodbld2020005348.pdf\">View full publication<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Talin-1 is the principal platelet Rap1 effector of integrin activation PLATELETS AND THROMBOPOIESIS| September 3, 2020 Recent Blood paper publication, collaborated with Mark Ginsberg, MD at UCSD to identify a unique mechanism regulating integrin-mediated platelet adhesion at sites of vascular injury: Wofgang Bergmeier, PhD and David Paul, PhD are co-authors on this study, showing that &hellip; <a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/\" aria-label=\"Read more about David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood\">Read more<\/a><\/p>\n","protected":false},"author":15383,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-3553","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood | UNC Blood Research Center\" \/>\n<meta property=\"og:description\" content=\"Talin-1 is the principal platelet Rap1 effector of integrin activation PLATELETS AND THROMBOPOIESIS| September 3, 2020 Recent Blood paper publication, collaborated with Mark Ginsberg, MD at UCSD to identify a unique mechanism regulating integrin-mediated platelet adhesion at sites of vascular injury: Wofgang Bergmeier, PhD and David Paul, PhD are co-authors on this study, showing that &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Blood Research Center\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-20T14:22:31+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-10-20T15:58:32+00:00\" \/>\n<meta name=\"author\" content=\"Christine Hill\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Christine Hill\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/\"},\"author\":{\"name\":\"Christine Hill\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/0053a5d22e9a1b875b2836c44bbbb0b0\"},\"headline\":\"David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood\",\"datePublished\":\"2020-10-20T14:22:31+00:00\",\"dateModified\":\"2020-10-20T15:58:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/\"},\"wordCount\":147,\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/\",\"name\":\"David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood | UNC Blood Research Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website\"},\"datePublished\":\"2020-10-20T14:22:31+00:00\",\"dateModified\":\"2020-10-20T15:58:32+00:00\",\"author\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/0053a5d22e9a1b875b2836c44bbbb0b0\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/\",\"name\":\"UNC Blood Research Center\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/0053a5d22e9a1b875b2836c44bbbb0b0\",\"name\":\"Christine Hill\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/d6a8adba6642bc914aa34dd8010949b416f664c36d4f07d40c9ad1cebab686c3?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/d6a8adba6642bc914aa34dd8010949b416f664c36d4f07d40c9ad1cebab686c3?s=96&d=mm&r=g\",\"caption\":\"Christine Hill\"},\"description\":\"Medicine-Hematology\",\"url\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/author\/chill1\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood | UNC Blood Research Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/","og_locale":"en_US","og_type":"article","og_title":"David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood | UNC Blood Research Center","og_description":"Talin-1 is the principal platelet Rap1 effector of integrin activation PLATELETS AND THROMBOPOIESIS| September 3, 2020 Recent Blood paper publication, collaborated with Mark Ginsberg, MD at UCSD to identify a unique mechanism regulating integrin-mediated platelet adhesion at sites of vascular injury: Wofgang Bergmeier, PhD and David Paul, PhD are co-authors on this study, showing that &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/","og_site_name":"UNC Blood Research Center","article_published_time":"2020-10-20T14:22:31+00:00","article_modified_time":"2020-10-20T15:58:32+00:00","author":"Christine Hill","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Christine Hill","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/"},"author":{"name":"Christine Hill","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/0053a5d22e9a1b875b2836c44bbbb0b0"},"headline":"David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood","datePublished":"2020-10-20T14:22:31+00:00","dateModified":"2020-10-20T15:58:32+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/"},"wordCount":147,"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/","url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/","name":"David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood | UNC Blood Research Center","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website"},"datePublished":"2020-10-20T14:22:31+00:00","dateModified":"2020-10-20T15:58:32+00:00","author":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/0053a5d22e9a1b875b2836c44bbbb0b0"},"breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2020\/10\/blood-publication-collaboration-wolfgang-bergmeier-phd-and-david-paul-phd\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/"},{"@type":"ListItem","position":2,"name":"David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website","url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/","name":"UNC Blood Research Center","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/0053a5d22e9a1b875b2836c44bbbb0b0","name":"Christine Hill","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/d6a8adba6642bc914aa34dd8010949b416f664c36d4f07d40c9ad1cebab686c3?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/d6a8adba6642bc914aa34dd8010949b416f664c36d4f07d40c9ad1cebab686c3?s=96&d=mm&r=g","caption":"Christine Hill"},"description":"Medicine-Hematology","url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/author\/chill1\/"}]}},"featured_image":false,"featured_image_medium":false,"featured_image_medium_large":false,"featured_image_large":false,"featured_image_thumbnail":false,"featured_image_alt":false,"category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/posts\/3553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/users\/15383"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/comments?post=3553"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/posts\/3553\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/media?parent=3553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/categories?post=3553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/tags?post=3553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}