{"id":3909,"date":"2021-04-07T15:55:55","date_gmt":"2021-04-07T19:55:55","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?p=3909"},"modified":"2021-04-07T16:05:36","modified_gmt":"2021-04-07T20:05:36","slug":"r01-awarded-to-rafal-pawlinski-phd-and-nigel-key-md","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2021\/04\/r01-awarded-to-rafal-pawlinski-phd-and-nigel-key-md\/","title":{"rendered":"R01 Awarded to Rafal Pawlinski PhD and Nigel Key MD"},"content":{"rendered":"<p>Two members of the UNC Blood Research Center, Rafal Pawlinski PhD and Nigel Key MD, both Professors in the Department of Medicine, Division of Hematology, have been awarded a $2.8 million, 4-year RO1 grant from the NIH-NHLBI to investigate the mechanism of venous thromboembolism (VTE) in sickle cell disease (SCD).<\/p>\n<p>Dr. Rafal Pawlinski and Dr. Nigel Key<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3910 alignright\" src=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/04\/SCD-clot-300x204.png\" alt=\"\" width=\"300\" height=\"204\" srcset=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/04\/SCD-clot-300x204.png 300w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/04\/SCD-clot-1024x698.png 1024w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/04\/SCD-clot-768x523.png 768w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/04\/SCD-clot-600x409.png 600w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/04\/SCD-clot.png 1187w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2462 alignleft\" src=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/01\/rafal-pawlinski.png\" alt=\"\" width=\"142\" height=\"188\" \/><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3317 alignleft\" src=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/07\/Key-UNC-photo-214x300.jpeg\" alt=\"Dr. Nigel Key\" width=\"136\" height=\"191\" srcset=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/07\/Key-UNC-photo-214x300.jpeg 214w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/07\/Key-UNC-photo-731x1024.jpeg 731w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/07\/Key-UNC-photo-768x1075.jpeg 768w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/07\/Key-UNC-photo-1097x1536.jpeg 1097w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/07\/Key-UNC-photo-1463x2048.jpeg 1463w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/07\/Key-UNC-photo-600x840.jpeg 600w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/07\/Key-UNC-photo.jpeg 1500w\" sizes=\"auto, (max-width: 136px) 100vw, 136px\" \/><\/p>\n<p>Recent epidemiologic data have established that individuals with SCD are at significantly increased risk of VTE, with an unusually high incidence of pulmonary emboli. The investigators will investigate whether unique properties of red blood cells (RBCs) in SCD contribute to the formation of unstable venous clots. More broadly, these studies are expected to contribute new insights into the role of cellular components in VTE.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Two members of the UNC Blood Research Center, Rafal Pawlinski PhD and Nigel Key MD, both Professors in the Department of Medicine, Division of Hematology, have been awarded a $2.8 million, 4-year RO1 grant from the NIH-NHLBI to investigate the mechanism of venous thromboembolism (VTE) in sickle cell disease (SCD). Dr. Rafal Pawlinski and Dr. &hellip; <a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2021\/04\/r01-awarded-to-rafal-pawlinski-phd-and-nigel-key-md\/\" aria-label=\"Read more about R01 Awarded to Rafal Pawlinski PhD and Nigel Key MD\">Read more<\/a><\/p>\n","protected":false},"author":15383,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-3909","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>R01 Awarded to Rafal Pawlinski PhD and Nigel Key MD | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2021\/04\/r01-awarded-to-rafal-pawlinski-phd-and-nigel-key-md\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"R01 Awarded to Rafal Pawlinski PhD and Nigel Key MD | UNC Blood Research Center\" \/>\n<meta property=\"og:description\" content=\"Two members of the UNC Blood Research Center, Rafal Pawlinski PhD and Nigel Key MD, both Professors in the Department of Medicine, Division of Hematology, have been awarded a $2.8 million, 4-year RO1 grant from the NIH-NHLBI to investigate the mechanism of venous thromboembolism (VTE) in sickle cell disease (SCD). 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