{"id":4740,"date":"2022-09-19T13:59:39","date_gmt":"2022-09-19T17:59:39","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?p=4740"},"modified":"2022-09-19T14:00:31","modified_gmt":"2022-09-19T18:00:31","slug":"brc-investigators-publish-results-of-randomized-trial-of-anti-fibrinolytic-therapy-and-ancillary-laboratory-study-in-blood-and-blood-advances","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2022\/09\/brc-investigators-publish-results-of-randomized-trial-of-anti-fibrinolytic-therapy-and-ancillary-laboratory-study-in-blood-and-blood-advances\/","title":{"rendered":"BRC Investigators Publish Results of Randomized Trial of Anti-Fibrinolytic Therapy and Ancillary Laboratory Study in \u2018Blood\u2019 and \u2018Blood Advances\u2019"},"content":{"rendered":"

\"Dr.\"\"In the NIH-funded \u2018American Trial Using Tranexamic Acid in Thrombocytopenia (A-TREAT)\u2019 trial, UNC was one of 3 participating clinical centers to enroll patients with platelet transfusion-dependence due to therapy for hematologic malignancies. Between 2016 and 2020, 337 patients were randomized in a double blind fashion to tranexamic acid (TXA) or placebo. Ultimately, no benefit of TXA on bleeding outcomes was observed. Drs. Nigel Key and Brandi Reeves were co-authors on this study. In an accompanying ancillary laboratory study that was also NIH-funded, \u2018home grown\u2019 plasma assays of fibrinolysis developed in Dr. Key\u2019s lab by Dr. Anton Ilich were used to explain why TXA may have been ineffective in this clinical scenario. Dr. Alisa Wolberg was a co-author on this study. (https:\/\/doi.org\/10.1182\/bloodadvances.2022008255<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"

In the NIH-funded \u2018American Trial Using Tranexamic Acid in Thrombocytopenia (A-TREAT)\u2019 trial, UNC was one of 3 participating clinical centers to enroll patients with platelet transfusion-dependence due to therapy for hematologic malignancies. Between 2016 and 2020, 337 patients were randomized in a double blind fashion to tranexamic acid (TXA) or placebo. Ultimately, no benefit of … Read more<\/a><\/p>\n","protected":false},"author":112194,"featured_media":3317,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-4740","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"\nBRC Investigators Publish Results of Randomized Trial of Anti-Fibrinolytic Therapy and Ancillary Laboratory Study in \u2018Blood\u2019 and \u2018Blood Advances\u2019 | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2022\/09\/brc-investigators-publish-results-of-randomized-trial-of-anti-fibrinolytic-therapy-and-ancillary-laboratory-study-in-blood-and-blood-advances\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BRC Investigators Publish Results of Randomized Trial of Anti-Fibrinolytic Therapy and Ancillary Laboratory Study in \u2018Blood\u2019 and \u2018Blood Advances\u2019 | UNC Blood Research Center\" \/>\n<meta property=\"og:description\" content=\"In the NIH-funded \u2018American Trial Using Tranexamic Acid in Thrombocytopenia (A-TREAT)\u2019 trial, UNC was one of 3 participating clinical centers to enroll patients with platelet transfusion-dependence due to therapy for hematologic malignancies. Between 2016 and 2020, 337 patients were randomized in a double blind fashion to tranexamic acid (TXA) or placebo. Ultimately, no benefit of … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2022\/09\/brc-investigators-publish-results-of-randomized-trial-of-anti-fibrinolytic-therapy-and-ancillary-laboratory-study-in-blood-and-blood-advances\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Blood Research Center\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-19T17:59:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-09-19T18:00:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/07\/Key-UNC-photo-731x1024.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"731\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"amshespe\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta 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