{"id":5767,"date":"2024-02-02T10:54:38","date_gmt":"2024-02-02T15:54:38","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?p=5767"},"modified":"2024-03-12T15:54:21","modified_gmt":"2024-03-12T19:54:21","slug":"recently-published-work-in-pnas-silvio-antoniak-phd-and-nigel-mackman-phd-groups","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2024\/02\/recently-published-work-in-pnas-silvio-antoniak-phd-and-nigel-mackman-phd-groups\/","title":{"rendered":"Recently published work in PNAS: Silvio Antoniak, PhD and Nigel Mackman, PhD"},"content":{"rendered":"<h4>In the recently published work in Proceedings of the National Academy of Sciences (PNAS), <strong>Dr. Antoniak\u2019s<\/strong> and <strong>Dr. Mackman\u2019s<\/strong> groups from the <strong>UNC Blood Research Center<\/strong> show that SARS-CoV-2 encodes antimicrobial peptides (xenoAMPs) which can form proinflammatory complexes. These complexes induced a proinflammatory and procoagulant phenotype \u00a0in cells in vitro and in mice in vivo. The findings point to a potential explanation why COIVD19 is associated with severe cytokine storm and thrombosis. Interestingly, the highly active xenoAMPs are unique to SARS-CoV-2 and are not found in common cold coronaviruses. The study was initiated by Dr. Wong with Dr. Zhang as first author from the Department of Biochemistry at the University of California Los Angeles. Other contributors were from the UNC-CH, UCLA, UCSD, Havard Medical School, Stanford University and Pacific Northwest National Laboratory.<\/h4>\n<p>&nbsp;<\/p>\n<h4><strong><a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2300644120\">Read article here<\/a><\/strong><\/h4>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the recently published work in Proceedings of the National Academy of Sciences (PNAS), Dr. Antoniak\u2019s and Dr. Mackman\u2019s groups from the UNC Blood Research Center show that SARS-CoV-2 encodes antimicrobial peptides (xenoAMPs) which can form proinflammatory complexes. These complexes induced a proinflammatory and procoagulant phenotype \u00a0in cells in vitro and in mice in vivo. &hellip; <a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2024\/02\/recently-published-work-in-pnas-silvio-antoniak-phd-and-nigel-mackman-phd-groups\/\" aria-label=\"Read more about Recently published work in PNAS: Silvio Antoniak, PhD and Nigel Mackman, PhD\">Read more<\/a><\/p>\n","protected":false},"author":15383,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-5767","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Recently published work in PNAS: Silvio Antoniak, PhD and Nigel Mackman, PhD | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2024\/02\/recently-published-work-in-pnas-silvio-antoniak-phd-and-nigel-mackman-phd-groups\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recently published work in PNAS: Silvio Antoniak, PhD and Nigel Mackman, PhD | UNC Blood Research Center\" \/>\n<meta property=\"og:description\" content=\"In the recently published work in Proceedings of the National Academy of Sciences (PNAS), Dr. Antoniak\u2019s and Dr. Mackman\u2019s groups from the UNC Blood Research Center show that SARS-CoV-2 encodes antimicrobial peptides (xenoAMPs) which can form proinflammatory complexes. These complexes induced a proinflammatory and procoagulant phenotype \u00a0in cells in vitro and in mice in vivo. &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2024\/02\/recently-published-work-in-pnas-silvio-antoniak-phd-and-nigel-mackman-phd-groups\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Blood Research Center\" \/>\n<meta property=\"article:published_time\" content=\"2024-02-02T15:54:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-12T19:54:21+00:00\" \/>\n<meta name=\"author\" content=\"Christine Hill\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Christine Hill\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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